LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to regulate the inflammatory response in grass carp

Fan, Kebin; Shen, Yubang; Xu, Xiaoyan; Tao, Lizhu; Bao, Tianjie; Li, Jiale

doi:10.1016/j.fsi.2021.02.003

Cited by 14 publications

(13 citation statements)

References 40 publications

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“…Increasing evidences suggest that lncRNAs can either enhance or impair bacterial‐mediated immunity 69 . During A. hydrophila infection in grass carp ( Ctenopharyngodon idella ) kidney (CIK) cells, two LncRNA named WAS and C8807 were found to be significantly up‐regulated, indicating their involvement in the inflammatory response against A. hydrophila infection 28 . This phenomenon has also been observed in higher mammals.…”

Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 80%

“…IRL/miRNA‐27c‐3p/IRAK4 axis regulates IRAK4‐mediated NF‐κB signalling 29 . WAS or C8807/miRNA‐142a‐3p axis also results in NF‐κB‐mediated bacterial response 28 in teleost.…”

Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 99%

“…LncRNA‐WAS and C8807 do interact with the miRNA named as 142a‐3p, through a competitive endogenous RNA mechanism, as observed in other higher mammals. One of the targets of miRNA 142a‐3p is tumour necrosis factor‐alpha‐induced protein 2 ( tnfaip2 ), which is a highly conserved single‐copy gene in the vertebrate evolution, whose expression could produce transcripts of interleukin 1‐beta ( il‐1β , involves in inflammation and immunity) and glucose transporter 3 ( glut3 , involves in glucose metabolism) 28,71,72 . MiRNA‐142a‐3p downregulates these two genes, which eventually lowers the pro‐inflammatory factors such as tumour necrosis factor‐alpha (TNF‐α) and interleukins (IL), as well as the fish immune responses.…”

Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 99%

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Long non‐coding RNA, a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost

Haridevamuthu

Guru

Velayutham

et al. 2022

Reviews in Aquaculture

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The global aquaculture boom, fuelled by a reduction in wild population and detection of novel viruses, has created a demanding market, hence, there is a pressing need to investigate the immune system of fish, further. As the most diverse community of vertebrates and a central contributor to the progressing global aquaculture market, teleost continues to draw vast scientific interest. Recent breakthroughs in multiomics technologies have provided a platform to understand the role of long noncoding RNA (lncRNA) in the host immune system during infection. Emerging evidence shows that teleost lncRNA might have a regulatory role in immune responses, mostly through lncRNA-microRNA (miRNA) sponging. Teleost lncRNA shares a functionally active short sequence complement to target the miRNA which is conserved among the several fish species. Recent report suggests that rhabdovirus exploits a lncRNA in teleost and, to dodge the host immune mechanism and negatively regulate the immune system. This observation reveals the essentiality of lncRNA in pathogendriven immunity in teleost. Reports available on the function of teleost lncRNA are still in early stages and experimental verifications are a limiting factor. Unravelling the lncRNA-mediated immune regulation in fishes could be used against the invading pathogens to strengthen the aquaculture production. This review elaborates on the experimentally identified and functionally characterized lncRNA and its regulatory role in the teleost immune response during infection and pathogen-driven host immune evolution, which could eventually lead to achieving high standards in aquaculture productivity.

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Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 80%

Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 99%

Section: Lncrna and Antibacterial Response In Teleostmentioning

confidence: 99%

See 1 more Smart Citation

Long non‐coding RNA, a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost

Haridevamuthu

Guru

Velayutham

et al. 2022

Reviews in Aquaculture

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“…microRNA-23b-5p regulated cell proliferation of hepatocellular carcinoma [67] and brown adipogenesis and thermogenic program in enhanced brown adipose tissue [68]. MiR-142a-3p was involved in the inflammatory response in grass carp [69], cute hypoxic stress in largemouth bass [63] and vascular development and integrity in zebrafish [70]. miR-142a-5p played critical roles in inflammation and tumorigenesis.…”

Section: Key Mirnas Regulating Head Developmentmentioning

confidence: 99%

Dynamic mRNA and miRNA expression of the head during early development in bighead carp (Hypophthalmichthys nobilis)

et al. 2022

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Background Head of fish species, an exquisitely complex anatomical system, is important not only for studying fish evolution and development, but also for economic values. Currently, although some studies have been made on fish growth and body shapes, very limited information is available on the molecular mechanism of head development. Results In this study, RNA sequencing (RNA–Seq) and small RNA sequencing (sRNA–Seq) technologies were used to conduct integrated analysis for the head of bighead carp at different development stages, including 1, 3, 5, 15 and 30 Dph (days post hatch). By RNA-Seq data, 26 pathways related to growth and bone formation were identified as the main physiological processes during early development. Coupling this to sRNA–Seq data, we picked out six key pathways that may be responsible for head development, namely ECM receptor interaction, TNF signaling pathway, osteoclast differentiation, PI3K–Akt signaling pathway, Neuroactive ligand–receptor interaction and Jak–STAT signaling pathway. Totally, 114 important candidate genes from the six pathways were obtained. Then we found the top 20 key genes according to the degree value by cytohubba, which regulated cell growth, skeletal formation and blood homeostasis, such as pik3ca, pik3r1, egfr, vegfa, igf1 and itga2b. Finally, we also acquired 19 key miRNAs playing multiple roles in the perfection of various tissues in the head (such as brain, eye and mouth) and mineralization of head bone system, such as let–7e, miR–142a–5p, miR–144–3p, miR–23a–3p and miR–223. Conclusions Results of this study will be informative for genetic mechanisms of head development and also provide potential candidate targets for the interaction regulation during early growth in bighead carp.

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“…With an annual output of 5.7 million tons in 2018, accounting for 6.9 percent of the world’s total farmed fish production, grass carp ( Ctenopharyngodon idella ) is the world’s most productive farmed fish kind [ 49 ]. Currently, grass carp lncRNA research focuses mostly on the immunological response to infection, environmental stress response, feeding, and growth [ 50 , 51 , 52 , 53 ], with no systematic study to describe lncRNAs. The availability of the draft grass carp genome has tremendously aided genetics breeding research and other basic grass carp research [ 52 , 54 , 55 , 56 , 57 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamic Transcriptional Landscape of Grass Carp (Ctenopharyngodon idella) Reveals Key Transcriptional Features Involved in Fish Development

Duan

Zhang²,

Jiang³

et al. 2022

IJMS

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A high-quality baseline transcriptome is a valuable resource for developmental research as well as a useful reference for other studies. We gathered 41 samples representing 11 tissues/organs from 22 important developmental time points within 197 days of fertilization of grass carp eggs in order to systematically examine the role of lncRNAs and alternative splicing in fish development. We created a high-quality grass carp baseline transcriptome with a completeness of up to 93.98 percent by combining strand-specific RNA sequencing and single-molecule real-time RNA sequencing technologies, and we obtained temporal expression profiles of 33,055 genes and 77,582 transcripts during development and tissue differentiation. A family of short interspersed elements was preferentially expressed at the early stage of zygotic activation in grass carp, and its possible regulatory components were discovered through analysis. Additionally, after thoroughly analyzing alternative splicing events, we discovered that retained intron (RI) alternative splicing events change significantly in both zygotic activation and tissue differentiation. During zygotic activation, we also revealed the precise regulatory characteristics of the underlying functional RI events.

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LncRNA-WAS and lncRNA-C8807 interact with miR-142a-3p to regulate the inflammatory response in grass carp

Cited by 14 publications

References 40 publications

Long non‐coding RNA, a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost

Long non‐coding RNA, a supreme post‐transcriptional immune regulator of bacterial or virus‐driven immune evolution in teleost

Dynamic mRNA and miRNA expression of the head during early development in bighead carp (Hypophthalmichthys nobilis)

Dynamic Transcriptional Landscape of Grass Carp (Ctenopharyngodon idella) Reveals Key Transcriptional Features Involved in Fish Development

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