LncRNA UCA1 regulates silicosis-related lung epithelial cell-to-mesenchymal transition through competitive adsorption of miR-204-5p

Guo, Yang; Tian, Yazhou; Li, Chao; Xia, Jiarui; Qi, Yuanmeng; Yao, Wu; Hao, Changfu

doi:10.1016/j.taap.2022.115977

Cited by 8 publications

(7 citation statements)

References 42 publications

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“…LncRNA UCA1 is one hotpot RNA in the study of human disorders. In the SiO 2 dust‐treated mouse silicosis model, the expression of UCA1 is correlated to the presence of silicosis 6 . As documented by Chen et al, UCA1 is highly expressed in patients with acute RDS and has the clinical possibility of differentiating these kinds of patients 7 .…”

Section: Introductionmentioning

confidence: 84%

Evaluation of the prognostic value of lncRNA UCA1 combined with extravascular lung water index and lung ultrasound score in patients with acute lung injury

Jiang

et al. 2023

Clinical Respiratory J

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Introduction Acute lung injury (ALI) is a common and rapidly developing critical inflammatory lung disease in clinic. This study investigated the predictive value of lncRNA UCA1, extravascular lung water index (EVLWI), and lung ultrasound score (LUS) in predicting the overall outcome of patients with ALI. Methods Patients with ALI were recruited for detecting the content of UCA1, EVLWI, and LUS. All patients were cataloged into the survival group and death group according to the prognosis. The discrepancy of UCA1, EVLWI, and LUS was compared in the two groups. The prognostic significance of UCA1, EVLWI, LUS, and their combination was estimated by logistic regression and the receiver operating characteristic (ROC) curve. Results The levels of UCA1, LUS, and EVLWI were elevated in the death group compared with the survival group. The content of UCA1 was positively correlated with LUS scores and EVLWI scores. UCA1, LUS, and EVLWI were independent indicators of predicting the prognosis of patients with ALI. The ROC curve reflected that UCA1, LUS, and EVLWI could forecast the endpoint events of patients with ALI whereas their combined approach had the highest accuracy. Conclusion Highly expressed UCA1 is a biomarker in forecasting the outcome of patients with ALI. It had high accuracy in predicting the endpoint of patients with ALI when combined with LUS and EVLWI.

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Section: Introductionmentioning

confidence: 84%

Evaluation of the prognostic value of lncRNA UCA1 combined with extravascular lung water index and lung ultrasound score in patients with acute lung injury

Jiang

et al. 2023

Clinical Respiratory J

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“…According to the published articles, increasing evidence has demonstrated the underlying mechanisms and functions of lncRNAs at multiple regulatory levels 42 . Many existing articles indicated that UCA1 acts as a microRNA (miRNA) sponge 43–46 . Under this mechanism, UCA1 functions as an endogenous mimic target of miRNAs, resulting in the regulation of mRNA which is affected by miRNAs.…”

Section: Discussionmentioning

confidence: 99%

“…42 Many existing articles indicated that UCA1 acts as a microRNA (miRNA) sponge. [43][44][45][46] Under this mechanism, UCA1 functions as an endogenous mimic target of miRNAs, resulting in the regulation of mRNA which is affected by miRNAs. Nevertheless, numerous studies fall short of identifying the targeted miRNA or the location of UCA1, with substantial miRNA data retrieved from databases.…”

Section: Discussionmentioning

confidence: 99%

lncRNA UCA1 promotes tumor progression by targeting SMARCD3 in cervical cancer

An,

Dong,

Chi

et al. 2023

Molecular Carcinogenesis

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Long noncoding RNA urothelial carcinoma associated 1 (UCA1) has been identified as a key molecule in human cancers. However, its functional implications remain unspecified in the context of cervical cancer (CC). This research aims to identify the regulatory mechanism of UCA1 in CC. UCA1 was identified through microarray and confirmed through a quantitative real‐time polymerase chain reaction. Proteins that bind with UCA1 were recognized using RNA pull‐down assays along with RNA immunoprecipitation. Ubiquitination assays and coimmunoprecipitation were performed to explore the molecular mechanisms of the SWI/SNF‐related, matrix‐associated, actin‐dependent regulator of chromatin, subfamily d, member 3 (SMARCD3) downregulated in CC. The effects of UCA1 and SMARCD3 on the progression of CC were investigated through gain‐ and loss‐of‐function assays and xenograft tumor formation in vivo. In this study, UCA1 was found to be upregulated in CC cells as well as in human plasma exosomes for the first time. Functional studies indicated that UCA1 promotes CC progression. Mechanically, UCA1 downregulated the SMARCD3 protein stabilization by promoting SMARCD3 ubiquitination. Taken together, we revealed that the UCA1/SMARCD3 axis promoted CC progression, which could provide a new therapeutic target for CC.

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“…Consequently, lncRNA MALAT1 could induce the onset of EMT and promote the process of lung fibrosis by adsorbing miR-145 [ 84 ]. In addition, a previous study established a silicosis mouse model and an in vitro EMT model of A549 cells and found that lncRNA UCA1 might regulate the EMT process by competitively adsorbing miR-204-5p to release its target gene ZEB1 [ 85 ].…”

Section: Ncrnamentioning

confidence: 99%

The emerging role of epigenetic regulation in the progression of silicosis

Yin

Xie

et al. 2022

Clin Epigenet

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Silicosis is one of the most severe occupational diseases worldwide and is characterized by silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are still lacking at present. Therefore, elucidating the pathogenesis of silicosis plays a significant guiding role for its treatment and prevention. The occurrence and development of silicosis are accompanied by many regulatory mechanisms, including epigenetic regulation. The main epigenetic regulatory mechanisms of silicosis include DNA methylation, non-coding RNA (ncRNA), and histone modifications. In recent years, the expression and regulation of genes related to silicosis have been explored at epigenetic level to reveal its pathogenesis further, and the identification of aberrant epigenetic markers provides new biomarkers for prediction and diagnosis of silicosis. Here, we summarize the studies on the role of epigenetic changes in the pathogenesis of silicosis to give some clues for finding specific therapeutic targets for silicosis.

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LncRNA UCA1 regulates silicosis-related lung epithelial cell-to-mesenchymal transition through competitive adsorption of miR-204-5p

Cited by 8 publications

References 42 publications

Evaluation of the prognostic value of lncRNA UCA1 combined with extravascular lung water index and lung ultrasound score in patients with acute lung injury

Evaluation of the prognostic value of lncRNA UCA1 combined with extravascular lung water index and lung ultrasound score in patients with acute lung injury

lncRNA UCA1 promotes tumor progression by targeting SMARCD3 in cervical cancer

The emerging role of epigenetic regulation in the progression of silicosis

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