LncRNA SOX2‐OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2

Wang, Zhi; Tan, Meiyun; Chen, Ge; Zhong, Li; Lu, Xiaobo

doi:10.1002/iub.1681

Cited by 66 publications

(55 citation statements)

References 28 publications

(37 reference statements)

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“…Stepwise mechanistic studies revealed ARAP1-AS1 enhanced c-Myc translation through competitively binding to PSF and dissociating PSF/ PTB complex, thereby promoting CC progression (Figure A growing body of evidence suggests that lncRNA is an effective biomarker of cancer. 16 For instance, LncRNA SOX2-OT, 17 EGFR-AS1, 18 LOC101928316, 19 and ZFAS1 20 were, respectively, identified as diagnostic or prognostic biomarkers for osteosarcoma, squamous cell carcinoma, gastric cancer, and colorectal cancer. In this study, we found that CC patients with high ARAP1-AS1 expression had shorter survival than patients with low ARAP1-AS1 expression, implying that ARAP1-AS1 is a promising prognostic biomarker for CC patients.…”

Section: Discussionmentioning

confidence: 99%

Retracted: Long non‐coding RNA ARAP1‐AS1 promotes tumorigenesis and metastasis through facilitating proto‐oncogene c‐Myc translation via dissociating PSF/PTB dimer in cervical cancer

Zhang

Wang

2020

Cancer Medicine

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Long non‐coding RNA (lncRNA) is emerging as a pivotal regulator in tumorigenesis and aggressive progression. Here, we focused on an oncogenic lncRNA, ARAP1 antisense RNA 1 (ARAP1‐AS1), which was notably upregulated in cervical cancer (CC) tissues, cell lines and serum. High ARAP1‐AS1 expression was closely associated with larger tumor size, advanced FIGO stage as well as lymph node metastasis. Importantly, it was identified as an effective diagnostic and prognostic biomarker for CC. In vitro and in vivo assays showed that knockdown of ARAP1‐AS1 inhibited, while overexpression of ARAP1‐AS1 promoted CC cell growth and dissemination. Stepwise mechanistic dissection unveiled that ARAP1‐AS1 could directly interact with PSF to release PTB, resulting in accelerating the internal ribosome entry site (IRES)‐driven translation of proto‐oncogene c‐Myc, thereby facilitating CC development and progression. Moreover, c‐Myc was able to transcriptionally activate ARAP1‐AS1 by directly binding to the E‐box motif located on ARAP1‐AS1 promoter. Taken together, our findings clearly reveal the crucial role of ARAP1‐AS1 in CC tumorigenesis and metastasis via regulation of c‐Myc translation, targeting ARAP1‐AS1 and its related regulatory loop implicates the therapeutic possibility for CC patients.

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Section: Discussionmentioning

confidence: 99%

Retracted: Long non‐coding RNA ARAP1‐AS1 promotes tumorigenesis and metastasis through facilitating proto‐oncogene c‐Myc translation via dissociating PSF/PTB dimer in cervical cancer

Zhang

Wang

2020

Cancer Medicine

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“…24 SOX2-OT has been reported to be upregulated in laryngeal squamous cell carcinoma and regulate osteosarcoma cells proliferation and motility through modulating SOX2. 9,25 Nevertheless, the biological significance and regulatory mechanism of SOX2-OT in NPC progression are largely to be clarified. In the present study, we found the expression level of SOX2-OT was higher in NPC tissues than that in the matched nonneoplastic tissues.…”

Section: Discussionmentioning

confidence: 99%

LncRNA SOX2‐OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR‐146b‐5p/HNRNPA2B1 pathway

Enqin¹,

2019

J of Cellular Biochemistry

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Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with a high mortality on account of its frequent metastasis and poor prognosis. An extensive body of investigations has proven that long noncoding RNAs are implicated in a variety of biological processes. Although SOX2‐OT has been reported to play an oncogenic role in osteosarcoma, the mechanism of SOX2‐OT‐driven NPC progression is still obscure. The aim of this study was to elucidate the biological function of SOX2‐OT and the related possible mechanism in NPC. In our study, SOX2‐OT was notably elevated in NPC samples and cells. Further, a high expression level of SOX2‐OT was correlated with poor clinical outcomes of NPC. Results from loss‐of‐function experiments suggested that knockdown of SOX2‐OT repressed cell proliferation, arrested cell cycle, facilitated cell apoptosis, and inhibited cell metastasis of NPC. To further investigate the molecular mechanism of SOX2‐OT, miR‐146b‐5p was found to directly bind to SOX2‐OT, which mediated the role of SOX2‐OT in NPC tumorigenesis. In addition, HNRNPA2B1 was a target of miR‐146b‐5p and SOX2‐OT modulated the expression of HNRNPA2B1 through competitively binding to miR‐146b‐5p. At last, we discovered that SOX2‐OT regulated NPC progression by targeting miR‐146b‐5p/HNRNPA2B1 pathway, which may provide more innovative targets for the treatment of patients with NPC.

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“…lncRNAs exhibit tissue specificity and functional diversity, which makes them potentially effective diagnostic and prognostic markers (8). Recent studies have revealed that lncRNA SOX2-OT functions as an oncogenic factor and serves an important role in numerous types of cancer, including osteosarcoma, cholangiocarcinoma and lung squamous cell carcinoma (9)(10)(11). Notably, using microarrays, Feng et al (12) identified that the expression of SOX2-OT in cancer tissues was significantly higher compared with that in adjacent non-neoplastic tissues in advanced laryngeal squamous cell carcinoma (LSCC).…”

Section: Introductionmentioning

confidence: 99%

lncRNA SOX2‑OT regulates laryngeal cancer cell proliferation, migration and invasion and induces apoptosis by suppressing miR‑654

Pan

Sun

et al. 2020

Exp Ther Med

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Laryngeal carcinoma is the most common type of malignant tumor in the head and neck. Long non-coding RNAs (lncRNAs) serve crucial roles in numerous biological processes. The present study aimed to investigate the role of lncRNA SOX2-OT in laryngeal cancer and to reveal the underlying mechanisms. Reverse transcription-quantitative PCR assays were used to measure the expression levels of SOX2-OT in the laryngeal cell lines. Furthermore, cell proliferation, apoptosis, migration and invasion were assessed by CCK-8, flow cytometry, wound healing and Transwell assays, respectively. Western blot assay was performed to detect the protein expressions. In addition, a dual-luciferase reporter assay was performed to confirm the direct interaction between SOX2-OT and microRNA (miR)-654. The data demonstrated that SOX2-OT level were significantly increased in the laryngeal cell lines. Furthermore, SOX2-OT silencing markedly promoted apoptosis and suppressed the proliferation, migration and invasion of TU-177 cells. A dual-luciferase reporter assay revealed that miR-654 was a direct target of SOX2-OT. Moreover, downregulation of miR-654 could attenuate cell apoptosis and accelerate cell proliferation, migration and invasion in TU-177 cells. In summary, the present study reported that knockdown of SOX2-OT could suppress cell proliferation, migration and invasion, and induce apoptosis in laryngeal cancer by targeting miR-654.

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LncRNA SOX2‐OT is a novel prognostic biomarker for osteosarcoma patients and regulates osteosarcoma cells proliferation and motility through modulating SOX2

Cited by 66 publications

References 28 publications

Retracted: Long non‐coding RNA ARAP1‐AS1 promotes tumorigenesis and metastasis through facilitating proto‐oncogene c‐Myc translation via dissociating PSF/PTB dimer in cervical cancer

Retracted: Long non‐coding RNA ARAP1‐AS1 promotes tumorigenesis and metastasis through facilitating proto‐oncogene c‐Myc translation via dissociating PSF/PTB dimer in cervical cancer

LncRNA SOX2‐OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR‐146b‐5p/HNRNPA2B1 pathway

lncRNA SOX2‑OT regulates laryngeal cancer cell proliferation, migration and invasion and induces apoptosis by suppressing miR‑654

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