“…Functioned as oncogenes or tumor suppressors, lncRNAs participate in several vital steps of GC tumorigenesis and progression. Some lncRNAs including HOTAIR, HULC, LINC00152, MALAT1, MALAT2, H19, SNHG6, GHET1 and GACAT3 have been demonstrated to act as oncogenes, while other lncRNAs such as LEIGC, GAS5 and FER1L4 have been classified as tumor suppressors [9][10][11][12]. Mechanistically, lncRNAs may act as chromatin remodeler, transcriptional modulator, splicing regulator, posttranscriptional processor, enhancer, molecular decoys for miRNAs, or as a guide for protein-protein, protein-DNA and protein-RNA interaction [4,5,13,14].…”