lncRNA SNHG5 is associated with poor prognosis of bladder cancer and promotes bladder cancer cell proliferation through targeting p27

Ma, Zuwei; Xue, Song; Bi, Zhang; Qiu, Daoxian

doi:10.3892/ol.2017.7527

Cited by 30 publications

(47 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is found that in the rat model of epilepsy, the over autophagy and apoptosis of hippocampal neurons can be antagonism by downregulation of lncRNA MALAT1, thus protecting the hippocampus of rats . LncRNA H19 has been reported to promote the apoptosis of hippocampal neurons by inhibiting let‐7b . LncRNA UCA1 inhibits seizures and brain damage caused by epilepsy by modulating the miR‐495/Nrf2‐ARE signaling pathway …”

Section: Discussionmentioning

confidence: 99%

“…23 LncRNA H19 has been reported to promote the apoptosis of hippocampal neurons by inhibiting let-7b. 24 LncRNA UCA1 inhibits seizures and brain damage caused by epilepsy by modulating the miR-495/Nrf2-ARE signaling pathway. 25 LncRNA GAS5 plays an important regulatory role in cancer progression, and it can inhibit oncogenes by inhibiting tumor cell proliferation, promoting apoptosis, and inhibiting cell migration and invasion.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3 by sponging miR‐135a‐5p to prevent the progression of epilepsy

Zheng

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

Epilepsy is one of the most common neurological disorders in humans. Recently, long noncoding RNAs (lncRNAs) have been reported to be important players in neurological diseases. Herein, this study aimed to examine the effect of lncRNA GAS5 on the occurrence of epilepsy in rat and cell models of epileptic seizure. The expression of lncRNA GAS5 was measured in the established rat and cell models. The binding sites between lncRNA GAS5 and miR‐135a‐5p, as well as those between miR‐135a‐5p and 3′ untranslated region of KCNQ3 were predicted by miRDB and Targetscan, separately, followed by verification using dual‐luciferase reporter gene assay. The expression of miR‐135a‐5p was measured in response to the overexpression of lncRNA GAS5. The mRNA and protein levels of KCNQ3 were examined in response to overexpression of miR‐135a‐5p. Next, the latency of epilepsy and frequency of epileptic seizures were assessed in rats injected with Lv‐shGAS5 and Lv‐miR‐135a‐5p in epileptic seizure model. In the rat and cell models, lncRNA GAS5 was highly expressed when epileptic seizure was induced. The expression of miR‐135a‐5p was decreased by overexpression of lncRNA GAS5. Meanwhile, the mRNA and protein levels of KCNQ3 were decreased in response to knockdown of miR‐135a‐5p. After the treatment of Lv‐shGAS5 and Lv‐miR‐135a‐5p, the average latent period of epilepsy was prolonged and the frequency of seizures was decreased. The key findings of the present study provide evidence emphasizing that lncRNA GAS5 functions as a competitive endogenous RNA of miR‐135a‐5p to increase expression of KCNQ3, and lncRNA GAS5 silencing inhibited the occurrence and progression of epilepsy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3 by sponging miR‐135a‐5p to prevent the progression of epilepsy

Zheng

et al. 2019

The Kaohsiung J of Med Scie

View full text Add to dashboard Cite

show abstract

“…SNHG5 consists of six exons and two nucleolar RNAs (snoRNAs) on human chromosome 6q14.3 [13]. The abnormal expression of SNHG5 has been found in many human cancers, such as bladder cancer, gastric cancer and colorectal cancer [14][15][16]. However, there are no reports on the molecular mechanism of SNHG5 in glioma.…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNA SNHG5 promotes glioma progression via miR-205/E2F3 axis

Liu

Luo

et al. 2019

Bioscience Reports

View full text Add to dashboard Cite

In recent years, many studies have reported on the abnormal expression and correlation of long non-coding RNAs (lncRNAs) in tumours. However, the accurate molecular mechanism of lncRNAs in glioma is still in its infancy. In the present study, we aimed to explore the molecular mechanism of small nucleolar RNA host gene 5 (SNHG5) in glioma progression. First, we found that SNHG5 expression was higher in glioma and was related to glioma glucose uptake, migration and invasion. Second, through a series of assays, we concluded that SNHG5 acts as a sponge for miR-205, which inhibits tumour growth in glioma by targeting E2F transcription factor 3 (E2F3). Third, using a xenograft mouse model, we demonstrated that SNHG5 regulates tumourigenesis in vivo. Taken together, our results show that the SNHG5/miR-205/E2F3 axis is involved in glioma progression and may provide a new therapeutic target for the diagnosis and therapy of glioma.

show abstract

“…LncRNAs have been also confirmed to regulate the progression of cancers by sponging miRNA [ 24 , 25 ]. Currently, lncRNA small nucleolar RNA host gene 5 (SNHG5) has been found to act as a tumor-promoting gene in bladder cancer and colorectal cancer [ 26 , 27 ] and a suppressor gene in gastric cancer [ 28 ]. Moreover, SNHG5 can also modulate the progression of cancer by competitively binding to miRNA [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, SNHG5 can also modulate the progression of cancer by competitively binding to miRNA [ 29 ]. These studies show that SNHG5 plays a significant role in a variety of different cancers [ 26 – 28 , 30 – 32 ]. However, the function of SNHG5 in osteosarcoma remains unclear, thus driving us to explore the role of SNHG5 in OS.…”

Section: Introductionmentioning

confidence: 99%

LncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis

et al. 2018

View full text Add to dashboard Cite

BackgroundLong non-coding RNA (lncRNA) SNHG5 has been found to play an important role in tumors. Nevertheless, the function and mechanism of lncRNA SNHG5 in osteosarcoma (OS) remains unclear. The purpose of this study was to investigate whether lncRNA SNHG5 can regulate the occurrence and development of OS cells.MethodsWe performed quantitative real time PCR to detect the expression of lncRNA SNHG5 in OS cells. 143B, MG63 (knockdown) and U2OS, U2R (overexpression) cell lines were chosen for the function study of SNHG5. The effect of SNHG5, miR-212-3p, and SGK3 in OS cells was explored by MTT assays, clony formation, flow cytometry, transwell assays, wound healing assays, and cell spreading assays. Quantitative real-time PCR, Western blot analysis and luciferase assays were used to detect the interaction between lncRNA SNHG5 and miR-212-3p.ResultsIn this study, knockdown of lncRNA SNHG5 suppressed the growth and metastasis of OS cells, whereas the overexpression of SNHG5 produced an opposite result. Mechanistically, lncRNA SNHG5 functions as a sponger against miR-212-3p and suppresses the miR-212-3p/SGK3 signaling pathway. Introduction of miR-212-3p mimics or inhibitors reverses SNHG5 overexpression or silences the exerted tumor promoting or suppressing effect. In addition, our results showed that the function of SNHG5 can be rescued by miR-212-3p and can regulate the growth and metastasis of OS cells via SGK3, the downstream target of miR-212-3p.ConclusionsIn summary, our study demonstrated that lncRNA SNHG5 can regulate the proliferation and metastasis of OS cells through the miR-212-3p/SGK3 axis. This axis may provide a new target for future clinical treatment.Electronic supplementary materialThe online version of this article (10.1186/s12935-018-0641-9) contains supplementary material, which is available to authorized users.

show abstract

lncRNA SNHG5 is associated with poor prognosis of bladder cancer and promotes bladder cancer cell proliferation through targeting p27

Cited by 30 publications

References 26 publications

Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3 by sponging miR‐135a‐5p to prevent the progression of epilepsy

Long noncoding RNA GAS5 silencing inhibits the expression of KCNQ3 by sponging miR‐135a‐5p to prevent the progression of epilepsy

Long non-coding RNA SNHG5 promotes glioma progression via miR-205/E2F3 axis

LncRNA SNHG5 promotes the progression of osteosarcoma by sponging the miR-212-3p/SGK3 axis

Contact Info

Product

Resources

About