LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion

Deng, Biyong; Pan, Runsang; Ou, Xin; Wang, Taizhe; Wang, Weiguo; Nie, Yingjie; Chen, Houping

doi:10.1155/2021/5271291

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…However, there has been a paucity of literature about RBM5-AS1 regarding its functions up to now. In different cancers, RBM5-AS1 was found to promote stem-like properties of colon cancer cells by recruiting β-catenin to the promoter regions of Wnt signaling target genes [ 9 ], RBM5-AS1 facilitates osteosarcoma cells [ 11 ], oral squamous cell carcinoma cells [ 12 ], and hepatocarcinoma cells [ 10 ] proliferation and metastasis through regulating RBM5, miR-1285-3p/YAP1 axis and silencing miR-132/212, respectively. RBM5-AS1 has also been demonstrated to inhibit bone cell apoptosis and promoted fracture healing by upregulating of β-catenin [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer

Yang

et al. 2022

Cell Death Dis

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Breast cancer is the most common malignancy among women across the globe. Recent studies have revealed that many long non-coding RNAs (lncRNAs) regulate the Wnt/β-catenin signaling pathway in several types of cancer. Hyperactivation of the Wnt/β-catenin pathway has been extensively presented in breast cancer and is involved in breast cancer progression. However, the underlying molecular mechanism remains elusive. In the current study, we found lncRNA RBM5-AS1 was remarkably upregulated in breast cancer cells and tissues. Overexpression of RBM5-AS1 facilitated proliferation, migration, invasion, EMT, and stemness maintenance of breast cancer cells in vitro and in vivo. Mechanism studies suggested that RBM5-AS1 could be transcriptionally activated by hypoxia-induced RUNX2. Upregulated RBM5-AS1 further activated the Wnt/β-catenin signaling by preventing β-catenin degradation and by helping organize β-catenin-TCF4 transcriptional complex. These findings suggested that RBM5-AS1, a regulator of Wnt/β-catenin signaling, plays a vital role in breast cancer initiation and progression, implicating its potential as a new target for breast cancer treatment.

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Section: Discussionmentioning

confidence: 99%

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer

Yang

et al. 2022

Cell Death Dis

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“…In the TARGET-OS data set, according to the immune score value obtained by the Estimation of Stromal and Immune cells in Malignant Tumour tissues using Expression data (ESTIMATE), the samples were divided into high and low immune score group by the median score. Then, differential expressed lncRNAs (DE-lncRNAs) were detected with a false discovery rate (FDR) <0.05 and |log2 (fold change)| ≥0.58 ( 21 ). Then, DE-lncRNAs intersect with IM-lncRNAs were used for univariate Cox regression analysis.…”

Section: Methodsmentioning

confidence: 99%

“…LncRNA antisense noncoding RNA from the RNA binding motive 5 (RBM5-AS1) promotes OS cell proliferation, migration, and invasion in vitro and tumor growth in vivo. LncRNA RBM5-AS1 targets RBM5 in OS cells ( 21 ). LncRNA PCAT-1 promotes the progression of OS, and the mir-508-3p/ Zinc finger E-box binding homeobox 1 (ZEB1) axis has been shown to be associated with the functional role of PCAT-1 in OS, which suggests that PCAT-1/Mir-508-3p/ZEB1 may be a therapeutic target for OS patients ( 22 ).…”

Section: Introductionmentioning

confidence: 99%

Bioinformatics analysis of lncRNAs in the occurrence and development of osteosarcoma

Liu¹,

Zong²,

Sun³

et al. 2022

Transl Pediatr

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Background: Osteosarcoma (OS) is a disease with high mortality in children and adolescents, and metastasis is one of its important clinical features. However, the molecular mechanism of OS occurrence is not completely clear. Thus, we screened potential biomarkers of OS and analyze their prognostic value. Methods:The Cancer Genome Atlas (TCGA) datasets were used to analyze the differential lncRNAs in patients with OS of different immune score and the lncRNAs expressed by immune cells. Cox regression was used to develop the prognosis prediction model and specify the prognosis outcomes. Risk-proportional regression model was constructed, and the samples were divided into high and low groups based on the risk scores for the survival analysis. The areas under the receiver operating characteristic (ROC) curve were calculated and the risk-score model was verified. Finally, using 4 gene sets (comprising chemokines, immune checkpoint blockades, immune activity-related genes, and immune cells), and 4 analysis tools (CIBERSORT, TIMER, XCELL and MCP) to evaluated tumor immune infiltration.Results: Twenty-nine long non-coding ribonucleic acids (lncRNAs) were obtained from the intersection of the screened lncRNAs. Caspase recruitment domain-containing protein 8-antisense RNA 1 (CARD8-AS1), lncRNA five prime to Xist (FTX), KAT8 regulatory NSL complex unit 1-antisense RNA 1 (KANSL1-AS1), Neuroplastin Intronic Transcript 1 (NPTN-IT1), oligodendrocyte maturation-associated long intervening non-coding RNA (OLMALINC) and RPARP Antisense RNA 1 (RPARP-AS1) were found to be correlated with survival. Univariate and multivariate regression analysis showed risk score [HR (hazard ratio) 3.5, P value 0.0043; HR 3.7, P value 0.0033] and metastasis (HR 4.7, P value 6.60E-05; HR 4.8, P value 8.36E-05) were the key factors of patients with OS. The areas under curves (AUCs) of the 1-, 3-, and 5-year ROC curves of the prognostic model were 0.715, 0.729, and 0.771. The low-risk patients tended to have a high abundance of immune cells.Conclusions: This study showed that a risk score based on 6 lncRNAs has potential value in the prognosis of OS, and patients with low-risk scores have high immune cell infiltration and good prognosis. This study may enrich understandings of underlying mechanisms related to the occurrence and development of OS.

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“…LncRNA RBM5-AS1 is a nuclear-retained transcript that selectively interacts with b-catenin (67). RBM5-AS1 is overexpressed in the OS tissues and cell lines, and the upregulated RBM5-AS1 promotes OS cell proliferation, migration, and invasion in vitro and tumor growth in vivo by (68). The lncRNA C5orf66 antisense 1 (C5orf66-AS1), a recently discovered lncRNA, has been reported to be associated with the pathogenesis of OS as well as other types of tumors, including cervical cancer, oral squamous cell carcinoma, liver cancer.…”

Section: Lncrna Acts As Oncogenementioning

confidence: 99%

Roles of lncRNAs in childhood cancer: Current landscape and future perspectives

et al. 2023

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According to World Health Organization (WHO), cancer is the leading cause of death for children and adolescents. Leukemias, brain cancers, lymphomas and solid tumors, such as neuroblastoma, ostesarcoma and Wilms tumors are the most common types of childhood cancers. Approximately 400,000 children and adolescents between the ages of 0 and 19 are diagnosed with cancer each year worldwide. The cancer incidence rates have been rising for the past few decades. Generally, the prognosis of childhood cancers is favorable, but the survival rate for many unresectable or recurring cancers is substantially worse. Although random genetic mutations, persistent infections, and environmental factors may serve as contributing factors for many pediatric malignancies, the underlying mechanisms are yet unknown. Long non-coding RNAs (lncRNAs) are a group of transcripts with longer than 200 nucleotides that lack the coding capacity. However, increasing evidence indicates that lncRNAs play vital regulatory roles in cancer initiation and development in both adults and children. In particular, many lncRNAs are stable in cancer patients’ body fluids such as blood and urine, suggesting that they could be used as novel biomarkers. In support of this notion, lncRNAs have been identified in liquid biopsy samples from pediatric cancer patients. In this review, we look at the regulatory functions and underlying processes of lncRNAs in the initiation and progression of children cancer and discuss the potential of lncRNAs as biomarkers for early detection. We hope that this article will help researchers explore lncRNA functions and clinical applications in pediatric cancers.

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LncRNA RBM5-AS1 Promotes Osteosarcoma Cell Proliferation, Migration, and Invasion

Cited by 5 publications

References 18 publications

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer

Hypoxia-induced lncRNA RBM5-AS1 promotes tumorigenesis via activating Wnt/β-catenin signaling in breast cancer

Bioinformatics analysis of lncRNAs in the occurrence and development of osteosarcoma

Roles of lncRNAs in childhood cancer: Current landscape and future perspectives

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