LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p

Jiang, Xingkang; Guo, Shuai; Zhang, Yangyi; Zhao, Yang; Li, Xiaojiang; Jia, Yulin; Xu, Yong; Ma, Ben

doi:10.1016/j.cellsig.2019.109422

Cited by 95 publications

(72 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies indicated NEAT1 functions as an oncogenic lncRNA in cancers. [7][8][9] In line with these studies, we showed NEAT1 was upregulated expression in both GC tissues and cells. In addition, we showed high NEAT1 level was an indicator of poorer overall survival of GC patients.…”

Section: Discussionsupporting

confidence: 82%

“…8 In prostate cancer, NEAT1 was found highly expressed in docetaxel-resistant samples, and its oncogenic role was exerted through sponging miR-34a-5p and miR-204-5p. 9 Moreover, NEAT1 was also found elevated expression in GC, and its overexpression was found to promote cancer peogewaaion via upregulating miR-17 and activating PI3K/AKT and GSK3β pathways. 10 lncRNA was found could exert its biological roles through competitively binding with miRNA.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

<p>Long Non-Coding RNA NEAT1 Serves as Sponge for miR-365a-3p to Promote Gastric Cancer Progression via Regulating ABCC4</p>

Gao

Liu

Zhang

et al. 2020

OTT

View full text Add to dashboard Cite

Long non-coding RNA (lncRNA) was reported to be a crucial regulator in cancer. In this work, our purpose is to explore the biological roles of nuclear paraspeckle assembly transcript 1 (NEAT1) in gastric cancer (GC). Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect NEAT1 expression in GC cells and normal cells. GC cell behaviors after NEAT1 overexpression or downregulation were analyzed by Cell Counting Kit-8 assay, colony formation assay, woundhealing assay, and flow cytometry assay. Bioinformatic tools were used to analyze the significance of NEAT1 in GC. The involvement of microRNA-365a-3p (miR-365a-3p) and ATP-binding cassette subfamily C member 4 (ABCC4) in the biological roles of NEAT1 in GC progression was validated by luciferase activity reporter assay and rescue experiments. Results: We found NEAT1 increased expression in both GC tissues and cells and correlated with poorer overall survival of cancer patients. We found NEAT1 overexpression promotes, while its knockdown inhibits GC cell proliferation, colony formation, invasion, and cell cycle progression in vitro. Mechanism analyses showed that NEAT1 serves as a ceRNA to upregulate ABCC4 expression via sponging miR-365a-3p. Conclusion: In this study, we revealed a NEAT1/miR-365a-3p/ABCC4 triplet in GC progression, which may provide novel targeted therapy markers for GC.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Introductionmentioning

confidence: 99%

<p>Long Non-Coding RNA NEAT1 Serves as Sponge for miR-365a-3p to Promote Gastric Cancer Progression via Regulating ABCC4</p>

Gao

Liu

Zhang

et al. 2020

OTT

View full text Add to dashboard Cite

show abstract

“…LinNEAT1 has been described in some studies as upregulated mRNA with different oncogenic effects on PCa cells. In PCa, it promotes the expression of the oncogene HMGA2 through the sponging of miR-98-5p, as well as leading to docetaxel resistance by sponging miR-34a-5p and miR-204-5p [65,104]. Furthermore, NEAT1 promotes the proliferation of PCa cells in connection with the steroid receptor co-activator (SCRC3) through the insulin-like growth factor 1 receptor/AKT serine/threonine kinase 1 (IGF1R/AKT) signaling pathway [105].…”

Section: Discussionmentioning

confidence: 99%

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors

Rochow

Jung

Weickmann

et al. 2020

IJMS

View full text Add to dashboard Cite

As new biomarkers, circular RNAs (circRNAs) have been largely unexplored in prostate cancer (PCa). Using an integrative approach, we aimed to evaluate the potential of circRNAs and their linear transcripts (linRNAs) to act as (i) diagnostic biomarkers for differentiation between normal and tumor tissue and (ii) prognostic biomarkers for the prediction of biochemical recurrence (BCR) after radical prostatectomy. In a first step, eight circRNAs (circATXN10, circCRIM1, circCSNK1G3, circGUCY1A2, circLPP, circNEAT1, circRHOBTB3, and circSTIL) were identified as differentially expressed via a genome-wide circRNA-based microarray analysis of six PCa samples. Additional bioinformatics and literature data were applied for this selection process. In total, 115 malignant PCa and 79 adjacent normal tissue samples were examined using robust RT-qPCR assays specifically established for the circRNAs and their linear counterparts. Their diagnostic and prognostic potential was evaluated using receiver operating characteristic curves, Cox regressions, decision curve analyses, and C-statistic calculations of prognostic indices. The combination of circATXN10 and linSTIL showed a high discriminative ability between malignant and adjacent normal tissue PCa. The combination of linGUCY1A2, linNEAT1, and linSTIL proved to be the best predictive RNA-signature for BCR. The combination of this RNA signature with five established reference models based on only clinicopathological factors resulted in an improved predictive accuracy for BCR in these models. This is an encouraging study for PCa to evaluate circRNAs and their linRNAs in an integrative approach, and the results showed their clinical potential in combination with standard clinicopathological variables.

show abstract

“…CPT1A synthesizes acylcarnitines, which are transported from the cytosol into the mitochondria, and their acyl groups are metabolized through the TCA cycle. NEAT1 also affects ACSL4 expression by competitively sponging both miR-34a-5p and miR-204-5p in prostate cancer ( 87 ). The alteration of ACSL4 expression is essential in the development and progression of breast and prostate cancers: ER expression is inversely correlated with ACSL4 expression in breast cancer ( 84 ), and ACSL4 is also involved in the loss of steroid hormone sensitivity and the acquisition of castration resistance in prostate cancer ( 85 , 88 ).…”

Section: Lipid Metabolism With Lncrnamentioning

confidence: 99%

Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers

et al. 2020

View full text Add to dashboard Cite

Breast and prostate cancers are the most prevalent cancers in females and males, respectively. These cancers exhibit sex hormone dependence and thus, hormonal therapies are used to treat these cancers. However, acquired resistance to hormone therapies is a major clinical problem. In addition, certain portions of these cancers initially exhibit hormone-independence due to the absence of sex hormone receptors. Therefore, precise and profound understanding of the cancer pathophysiology is required to develop novel clinical strategies against breast and prostate cancers. Metabolic reprogramming is currently recognized as one of the hallmarks of cancer, as exemplified by the alteration of glucose metabolism, oxidative phosphorylation, and lipid metabolism. Dysregulation of metabolic enzymes and their regulators such as kinases, transcription factors, and other signaling molecules contributes to metabolic alteration in cancer. Moreover, accumulating lines of evidence reveal that long non-coding RNAs (lncRNAs) regulate cancer development and progression by modulating metabolism. Understanding the mechanism and function of lncRNAs associated with cancer-specific metabolic alteration will therefore provide new knowledge for cancer diagnosis and treatment. This review provides an overview of recent studies regarding the role of lncRNAs in metabolism in breast and prostate cancers, with a focus on both sex hormone-dependent and -independent pathways.

show abstract

LncRNA NEAT1 promotes docetaxel resistance in prostate cancer by regulating ACSL4 via sponging miR-34a-5p and miR-204-5p

Cited by 95 publications

References 33 publications

<p>Long Non-Coding RNA NEAT1 Serves as Sponge for miR-365a-3p to Promote Gastric Cancer Progression via Regulating ABCC4</p>

<p>Long Non-Coding RNA NEAT1 Serves as Sponge for miR-365a-3p to Promote Gastric Cancer Progression via Regulating ABCC4</p>

Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors

Long Non-coding RNAs Involved in Metabolic Alterations in Breast and Prostate Cancers

Contact Info

Product

Resources

About