LncRNA NEAT1 activates MyD88/NF-κB pathway in bronchopneumonia through targeting miR-155-5p

hASCs-derived exosomal miR-155-5p targeting TGFβR2 promotes autophagy and reduces pyroptosis to alleviate intervertebral disc degeneration

“…reported that miR-155-5p was downregulated in BEAS-2B cells induced by LPS. Overexpression of miR-155-5p increased cell proliferation and suppressed inflammatory factors levels and cell apoptosis [ 42 ]. Furthermore, lower expression of miR-155-5p was observed in exosomes from LPS-stimulated periodontal ligament stem cells compared with exosomes from normal periodontal ligament stem cells.…”

A comprehensive insight into the immunomodulatory role of MSCs‐derived exosomes (MSC‐Exos) through modulating pattern‐recognition receptors (PRRs)

“…By downregulating these molecules, miR-155 limits the activation of these receptors and their downstream pro-inflammatory responses. 124 In systemic lupus erythematosus (SLE), miR-155 is often upregulated. Delivering MSC-Exos containing miR-155 inhibitors can help reduce the aberrant TLR and NLR signaling seen in SLE patients, mitigating the autoimmune responses characteristic of the disease.…”

The tumor therapeutic potential of long non-coding RNA delivery and targeting

“…By acting as ceRNA, lncRNAs could realize the effect of a series of function, like glucose metabolism, immune system, autophagy, apoptosis, etc. 33 For example, oncogenic lncRNA NEAT1 could act as a sponge for miR-155-5p to promote the expression of immune suppressor factor T cell immunoglobulin mucin-3 (Tim-3) 34 . By enhancing the expression of Tim-3, it leads to NEAT1 facilitated immune escape of HCC cells.…”