LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding to SENP1 to promote intestinal fibrosis in Crohn's disease

The role of long non-coding RNA in Crohn's disease

“…These molecules are recognized for their role as diagnostic markers and therapeutic targets in various diseases, including CD [ 13 ]. The Dysregulation of lncRNA-mediated processes contributes to the development of CD, which includes inflammatory response, immune regulation, intestinal tissue damage repair [ 14 ]. LncRNAs exhibit a more extensive range of regulatory mechanisms in CD compared to other non-coding RNAs, including autophagy regulation, DNA methylation, and histone modification.…”

“… LncRNA Sample source Assay method Location Effect on CD Ref. MSC-AS1 Human and Rats colonic tissue qRT-PCR chr8:72,279,244-72,491,399 Activate EMT [ 14 ] H19 Human blood qRT-PCR chr11:1,995,176–1997835 (−) Promote inflammation [19 20] MALAT1 Human and mice intestinal mucosal tissue Microarray/qRT-PCR chr11:65497688–65506516 (+) Impaired mucosal barrier [22 23] LUCAT1 Human blood qRT-PCR chr5:91054834-91314547 (−) Promote inflammation [ 25 ] LINC01272 Human Colonic and ileal tissue qRT-PCR/Microarray Chr20:NC_000020.11 Activate EMT [ [26] , [27] , [28] ] DQ786243 Human blood qRT-PCR chr1:155234457-155239960 Generate regulatory T lymphocytes [ 29 ] MEG3 Human colonic tissue qRT-PCR Chr14:NC_000014.9 Promoted TNF-α [ 31 ] THRIL Human blood qRT-PCR Chr12:NC_000012.12 Promote inflammation …”

“…LncRNA MSC-AS1 has been found to be highly expressed in pancreatic cancer, hepatocellular carcinoma and glioma [ 17 ]. In the intestinal tissue of CD mice induced by 2,4,6-trinitrobenzenesulfonic acid, MSC-AS1 was not only highly expressed but also induced intestinal fibrosis by promoting epithelial-mesenchymal transition (EMT) [ 14 ].…”