LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas

Zhu, Haibo; Li, Bin; Guo, Jing; Miao, Yazhou; Shen, Yutao; Zhang, Yazhou; Zhao, Peng; Li, Chuzhong

doi:10.18632/aging.203048

Cited by 17 publications

(14 citation statements)

References 26 publications

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“…LncRNAs perform these functions through different mechanisms, including acting as competing endogenous RNAs (ceRNAs) that sponge miRNAs or proteins [ 70 ], promoting or inhibiting long-range chromatin interactions [ 71 , 72 ], acting as molecular scaffolds for guiding chromatin-modifying enzymes [ 73 , 74 , 75 ], and even functioning through the behavior of transcription itself [ 64 , 76 ]. Given the important roles of lncRNAs in the regulation of epigenetic processes, the dysregulation of lncRNAs is implicated in many human diseases [ 9 , 77 , 78 , 79 ]. In addition, increasing studies have shown that lncRNA is involved in the progression, proliferation, apoptosis, autophagy, and metastasis of PA.…”

Section: Lncrna and Pamentioning

confidence: 99%

Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma

Cao

Jia

et al. 2022

Cells

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Pituitary adenoma (PA) is a common intracranial tumor without specific biomarkers for diagnosis and treatment. Non-coding RNAs (ncRNAs), including microRNAs (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA), regulate a variety of cellular processes, such as cell proliferation, differentiation, and apoptosis. Increasing studies have shown that the dysregulation of ncRNAs, especially the cross-talk between lncRNA/circRNA and miRNA, is related to the pathogenesis, diagnosis, and prognosis of PA. Therefore, ncRNAs can be considered as promising biomarkers for PA. In this review, we summarize the roles of ncRNAs from different specimens (i.e., tissues, biofluids, cells, and exosomes) in multiple subtypes of PA and highlight important advances in understanding the contribution of the cross-talk between ncRNAs (e.g., competing endogenous RNAs) to PA disease.

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Section: Lncrna and Pamentioning

confidence: 99%

Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma

Cao

Jia

et al. 2022

Cells

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“…MEG8 silencing has considerably decreased tumor growth and burden in animal models of lung cancer [ 8 ]. This lncRNA has a similar effect bone-invasive pituitary adenomas [ 12 ].…”

Section: Animal Studiesmentioning

confidence: 99%

“…Moreover, MEG8 has been shown to participate in the progression of bone-invasive pituitary adenoma through sponging miR-454-3p and increasing TNF-α expression [ 12 ]. Similarly, expression of MEG8 has been found to be elevated in Wilms tumor cells, parallel with up-regulation of CRK and down-regulation of miR-23a-3p.…”

Section: Introductionmentioning

confidence: 99%

“…↑ MEG8: ↑ EMT process [ 9 ] Pancreatic cancer miR-34a and miR-203, EZH2, SNAI1 and SNAI2 Panc1 MEG8 was involved in EZH2 recruitment to inhibit miR-34a and miR-203 expression. ↑ MEG8: ↑ EMT process Hemangioma miR203, Notch signaling pathway HemECs ∆ MEG8: ↓ proliferation, ↓ migration, ↑ apoptosis [ 10 ] miR-497-5p, NOTCH2 HemECs ∆ MEG8: ↓ proliferation, ↑ ferroptosis [ 21 ] Hepatocellular carcinoma miR-367-3p, 14-3-3ζ, TGFβR1, TGFβ signaling Human LO2 hepatocytes and HepG2, Huh7, HCCLM3, and HMCC-97 H HCC ∆ MEG8: ↓ proliferation, ↓ migration, ↓ invasion [ 11 ] Bone-invasive pituitary adenomas miR-454-3p, TNF-α 293T and RAW264.7 ↑ MEG8: ↑ promoting RAW264.7 cells to destroy bone [ 12 ] Wilms’ tumor miR-23a-3p, CRK WT cells ∆ MEG8: ↓ viability, ↓ migration, ↓ invasion [ 13 ] Diabetic nephropathy miR-770-5p CIHP-1 ↑ MEG8: ↑ glucose-mediated apoptosis, ↑ miR-770-5p expression by reducing the methylation of miR-770-5p [ 14 ] Atherosclerosis miR-181a, PPARα VSMCs ↑ MEG8: ↓ VSMC proliferation, ↓ migration, ↑ apoptosis [ 15 ] Ischemic stroke miR-130a-5p, VEGFA OGD-treated BMECs ∆ MEG8: ↓ viability, ↓ migration, ↓ angio...…”

Section: Introductionmentioning

confidence: 99%

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A review on the role of MEG8 lncRNA in human disorders

et al. 2022

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Maternally expressed 8 (MEG8) is a long non-coding RNA which is expressed in the nucleus. It is highly expressed in adrenal, placenta and brain. Recent studies have shown contribution of MEG8 in different disorders ranging from neoplastic ones to diabetic nephropathy, atherosclerosis, ischemic stroke, trophoblast dysfunction and abortion, Henoch-Schonlein purpura and osteoarthritis. It has an oncogenic role in the development of lung, pancreatic and liver cancer. In the current review, we summarize the role of this lncRNA in mentioned disorders, based on the evidence obtained from in vitro, in vivo and human studies.

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“…Xue and Ge [ 9 ] identified differentially expressed lncRNAs in PAs and revealed the key lncRNAs associated with the progression of PAs. Moreover, Guo et al [ 10 ] showed that some lncRNAs were associated with the recurrence of nonfunctioning PAs, whereas Zhu et al [ 11 ] demonstrated that the increased expression levels of the lncRNA maternally expressed 8 promoted bone destruction in bone-invasive PAs by regulating miR-454-3p/tumor necrosis factor (TNF)- α axis. Thus, exploring the expression patterns of lncRNAs in IPAs might confirm the existence of novel potential biomarkers for the diagnosis of IPAs.…”

Section: Introductionmentioning

confidence: 99%

lncRNA–mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis

Peng

Wang

et al. 2022

BioMed Research International

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Background. Long noncoding RNAs (lncRNAs) play important roles in the tumorigenesis and progression of various cancer types; however, their roles in the development of invasive pituitary adenomas (PAs) remain to be investigated. Methods. lncRNA microarray analysis was performed for three invasive and three noninvasive PAs. Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis were performed, and coexpression networks between lncRNA and mRNA were constructed. Furthermore, three differentially expressed lncRNAs were selected for validation in PA samples by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The diagnostic values of these three lncRNAs were further evaluated by a receiver operating characteristic (ROC) curve analysis. Results. A total of 8872 lncRNAs were identified in invasive and paired noninvasive PAs via lncRNA microarray analysis. Among these, the differentially expressed lncRNAs included 81 that were upregulated and 165 that were downregulated. GO enrichment and KEGG pathway analysis showed that these differentially expressed lncRNAs were associated with the posttranslational modifications of proteins. Furthermore, we performed target gene prediction and coexpression analysis. The interrelationships between the significantly differentially expressed lncRNAs and mRNAs were identified. Additionally, three differentially expressed lncRNAs were selected for validation in 41 PA samples by qRT-PCR. The expression levels of FAM182B, LOC105371531, and LOC105375785 were significantly lower in the invasive PAs than in the noninvasive PAs ( P < 0.05 ). These results were consistent with the microarray data. ROC curve analysis suggested that the expression levels of FAM182B and LOC105375785 could be used to distinguish invasive PAs from noninvasive PAs. Conclusion. Our findings demonstrated the expression patterns of lncRNAs in invasive PAs. FAM182B and LOC105375785 may be involved in the invasiveness of PAs and serve as new candidate biomarkers for the diagnosis of invasive PAs.

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LncRNA MEG8 promotes TNF-α expression by sponging miR-454-3p in bone-invasive pituitary adenomas

Cited by 17 publications

References 26 publications

Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma

Emerging Roles of miRNA, lncRNA, circRNA, and Their Cross-Talk in Pituitary Adenoma

A review on the role of MEG8 lncRNA in human disorders

lncRNA–mRNA Expression Patterns in Invasive Pituitary Adenomas: A Microarray Analysis

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