LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer

Wang, Wei; Xie, Ying; Chen, Fei; Liu, Xu; Zhong, Lili; Wang, Hai-Qiang; Li, Qingchang

doi:10.3748/wjg.v25.i29.3972

Cited by 49 publications

(34 citation statements)

References 37 publications

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“…However, the molecular mechanisms that underlie CRC tumorigenesis are yet to be fully elucidated. There is increasing evidence that lncRNAs acting as oncogenes or anti-oncogene factors have functions in tumorigenesis and tumor metastasis in CRC cells (5,8,26,27).…”

Section: Discussionmentioning

confidence: 99%

“…For example, MEG3, as a competing endogenous RNA, reduces the invasiveness of human bladder cancer cells by competing with PHLPP2 mRNA for miR-27a (30); MEG3 inhibits the proliferation of epithelial ovarian cancer cells by regulating ATG3 activity and inducing autophagy (31); and MEG3 inhibits the proliferation and invasion of gallbladder cancer by associating with EZH2 and promoting its ubiquitination (32). Some recent studies have reported that the amounts of MEG3 are significantly reduced in tissue and serum from patients with CRC and that this can serve as a prognostic marker in such patients (8,28,33). However, the role of MEG3 in CRC remains largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Downregulation of MEG3 has been observed in CRC tissues (8,21). To further confirm this, we used RT-qPCR to measure MEG3 expression in 80 CRC samples and the matched samples of adjacent normal mucosa.…”

Section: Meg3 Is Downregulated In Crc and Associated With Tumor Prognmentioning

confidence: 99%

“…Among them, maternally expressed gene 3 (MEG3) has been reported to be aberrantly expressed in CRC and may act as a tumor suppressor (8)(9)(10). However, the mechanism of action of MEG3 in CRC requires further investigation.…”

Section: Introductionmentioning

confidence: 99%

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Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation

Zuo

Wang

et al. 2020

Front. Oncol.

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Colorectal cancer (CRC), a common tumor, is characterized by a high mortality rate. Long non-coding RNA maternally expressed gene 3 (MEG3) serves a regulatory role in the carcinogenesis and progression of several types of cancer; however, its role in CRC remains largely unknown. The aim of this study was to explore the regulatory role and mechanism(s) of MEG3 in CRC. The Warburg effect or aerobic glycolysis is characteristic of the metabolism of tumor cells. To determine the effect of MEG3 on glycolysis of CRC cells, we used an XF analyzer to perform glycolysis stress test assays and found that overexpression of MEG3 significantly inhibited glycolysis, glycolytic capacity, as well as lactate production in CRC cells, whereas knockdown of MEG3 produced the opposite effect. Mechanistically, overexpression of MEG3 induced ubiquitin-dependent degradation of c-Myc and inhibited c-Myc target genes involved in the glycolysis pathway such as lactate dehydrogenase A, pyruvate kinase muscle 2, and hexokinase 2. Moreover, we found that MEG3 can be activated by vitamin D and vitamin D receptor (VDR). Clinical data demonstrated that MEG3 was positively associated with serum vitamin D concentrations in patients with CRC. We found that 1,25(OH) 2 D 3 treatment increased MEG3 expression, and knockdown of VDR abolished the effect of MEG3 on glycolysis. These results indicate that vitamin D-activated MEG3 suppresses aerobic glycolysis in CRC cells via degradation of c-Myc. Thus, vitamin D may have therapeutic value in the treatment of CRC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Meg3 Is Downregulated In Crc and Associated With Tumor Prognmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation

Zuo

Wang

et al. 2020

Front. Oncol.

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“…Thus, alloying is an effective approach to improve the bond strength of TM-B bond and then enhance the Vickers hardness of TMBs superhard material. [23][24][25][26] For example, Kaner et al work has shown that the measured Vickers hardness of WB 4 with alloyed 20 at% Ti, 10 at% Zr and 6 at% Hf is up to 50.9 AE 2.2 GPa, 55.9 AE 2.7 GPa and 51.6 AE 2.8 GPa, respectively. 27 The WB is not a superhard material.…”

Section: Introductionmentioning

confidence: 99%

Enhancing the Vickers hardness, melting point and thermodynamic properties of hafnium dodecaboride

2019

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Molecular regulation of hypoxia through the lenses of noncoding RNAs and epitranscriptome

Islam

Mukherjee

2022

WIREs RNA

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Cells maintain homeostasis in response to environmental stress through specific cell stress responses. Hypoxic stress, well known to be associated with diverse solid tumors, is one of the main reasons for cancer-related mortality. Although cells can balance themselves well during hypoxic stress, the underlying molecular mechanisms are not well understood. The enhanced appreciation of diverse roles played by noncoding transcriptome and epigenome in recent years has brought to light the involvement of noncoding RNAs and epigenetic modifiers in hypoxic regulation. The emergence of techniques like deep sequencing has facilitated the identification of large numbers of long noncoding RNAs (lncRNAs) that are differentially regulated in various cancers. Similarly, proteomic studies have identified diverse epigenetic modifiers such as HATs, HDACs, DNMTs, polycomb groups of proteins, and their possible roles in the regulation of hypoxia. The crosstalk between lncRNAs and epigenetic modifiers play a pivotal role in hypoxia-induced cancer initiation and progression. Besides the lncRNAs, several other noncoding RNAs like circular RNAs, miRNAs, and so forth are also expressed during hypoxic conditions.Hypoxia has a profound effect on the expression of noncoding RNAs and epigenetic modifiers. Conversely, noncoding RNAs/epigenetic modifies can regulate the hypoxia signaling axis by modulating the stability of the hypoxiainducible factors (HIFs). The focus of this review is to illustrate the molecular orchestration underlying hypoxia biology, especially in cancers, which can help in identifying promising therapeutic targets in hypoxia-induced cancers.

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LncRNA MEG3 acts a biomarker and regulates cell functions by targeting ADAR1 in colorectal cancer

Cited by 49 publications

References 37 publications

Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation

Long Non-coding RNA MEG3 Activated by Vitamin D Suppresses Glycolysis in Colorectal Cancer via Promoting c-Myc Degradation

Enhancing the Vickers hardness, melting point and thermodynamic properties of hafnium dodecaboride

Molecular regulation of hypoxia through the lenses of noncoding RNAs and epitranscriptome

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