volume 8, issue 9, P2182-2203 2016
DOI: 10.18632/aging.101062
View full text
Deying Yang, Ting Lian, Jianbo Tu, Uma Gaur, Xueping Mao, Xiaolan Fan, Diyan Li, Ying Li, Mingyao Yang

Abstract: Dietary restriction (DR) extends lifespan in many species which is a well-known phenomenon. Long non-coding RNAs (lncRNAs) play an important role in regulation of cell senescence and important age-related signaling pathways. Here, we profiled the lncRNA and mRNA transcriptome of fruit flies at 7 day and 42 day during DR and fully-fed conditions, respectively. In general, 102 differentially expressed lncRNAs and 1406 differentially expressed coding genes were identified. Most informatively we found a large numb…

expand abstract