LncRNA MALAT1 promotes tumorigenesis and immune escape of diffuse large B cell lymphoma by sponging miR-195

Wang, Qing-Ming; Lian, Guang-Yu; Yuan, Sheng; Huang, Yanfang; Gong, Yi

doi:10.1016/j.lfs.2019.03.040

Cited by 138 publications

(110 citation statements)

References 38 publications

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“…Previous research has shown that PD-L1 expression is involved in two main mechanisms: the innate immune escape, which is associated with multiple oncogenes, and the adaptive immune escape, which consists of various tumor microenvironment inflammatory factors ( Zhang et al., 2013 ; Pardoll, 2012 ; Rech & Vonderheide, 2013 ; Taube et al., 2012 ). Wang et al. (2019a) and Wang et al.…”

Section: Discussionmentioning

confidence: 99%

ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways

Wang

Tang

Zhao

et al. 2020

PeerJ

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Purpose Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and associated pathways of zinc finger protein multitype 2 antisense RNA 1 (ZFPM2-AS1) in NSCLC cells. Methods We used qRT-PCR to analyze ZFPM2-AS1’s transcription level. Its proliferation, migration, and invasion capacities were determined using MTT, colony forming, wound healing, and transwell assays. We additionally analyzed the correlation between ZFPM2 and immune infiltration using the Tumor Immune Estimation Resource (TIMER) database, and the protein expression levels using Western blots. Results We found that ZFPM2-AS1 expression in NSCLC specimens and cell lines was elevated compared to the control group. ZFPM2-AS1 is an oncogene and independent prognostic predictor of poor survival in NSCLCs, and its expression had a positive correlation with tumor size and lymph node metastasis in our clinical data. MTT, colony forming, wound healing, and transwell assays showed a positive correlation between ZFPM2-AS1 expression and the proliferation, migration, and invasion of NSCLC cells in the presence and absence of interferon- (IFN-γ). Using the TIMER database, we hypothesized that ZFPM2 was negatively correlated with ZFPM2-AS1 expression, as well as the immune infiltration levels in lung adenocarcinoma (LUAD). Finally, we found that ZFPM2-AS1 negatively regulated ZFPM2 expression, and had a positive correlation with PD-L1 expression through the JAK-STAT and AKT pathways. Conclusion Our study confirmed that ZFPM2-AS1 promotes the proliferation, migration, and invasion of NSCLC cells via the JAK-STAT and AKT pathways. Further research on the ZFPM2-AS1 pathway regulation mechanism is needed.

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Section: Discussionmentioning

confidence: 99%

ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways

Wang

Tang

Zhao

et al. 2020

PeerJ

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“…Other studies also reported that lncRNA LINC00473 sponged miR-195-5p to enhance the expression of PD-L1 in prostate cancer (77), while lncRNA MALAT1 regulated tumor migration and immune evasion by modulating the miR-195/PD-L1 axis in diffuse large B-cell lymphoma (51) and the miR-200a-3p/PD-L1 axis in lung cancer (69), respectively. Soluble factors secreted by the immune cells also affect the expression of MALAT1.…”

Section: Expression Of Molecules In Tumor Cellsmentioning

confidence: 92%

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Luo

Yang

et al. 2020

Front. Oncol.

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“…LncRNA-SNHG14/miR-5590-3p/ZEB1 forms the positive feedback loop to foster immune escape and lymphoma progression via modulating PD-1/PD-L1 checkpoint [ 77 ]. LncRNA-MALAT1 fuels immune evasion of lymphoma by targeting miR-195 [ 78 ]. MALAT1 silence facilitates proliferation of CD8 + T cells and hinders EMT-like process by Ras/ERK signaling pathway [ 78 ].…”

Section: Introductionmentioning

confidence: 99%

“…LncRNA-MALAT1 fuels immune evasion of lymphoma by targeting miR-195 [ 78 ]. MALAT1 silence facilitates proliferation of CD8 + T cells and hinders EMT-like process by Ras/ERK signaling pathway [ 78 ].…”

Section: Introductionmentioning

confidence: 99%

“…Besides, above-mentioned SNHG14 also can induce interaction of tumor cells with CD8 + T cells by mediating miR-5590-3p, and causing apoptosis of CD8 + T cells via PD-1/PD-L1 immune checkpoint, and eventually contributing to the immune evasion of cancer cells [ 77 ]. LncRNA MALAT1 sponges miR-195 to regulate proliferation and apoptosis of CD8 + T cells by PD-L1, and in turn adjust immune escape abilities [ 78 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

Zhang

Liu

Liao

2020

J Exp Clin Cancer Res

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Long noncoding RNAs (lncRNAs) are a class of endogenous, non-protein coding RNAs that are highly linked to various cellular functions and pathological process. Emerging evidence indicates that lncRNAs participate in crosstalk between tumor and stroma, and reprogramming of tumor immune microenvironment (TIME). TIME possesses distinct populations of myeloid cells and lymphocytes to influence the immune escape of cancer, the response to immunotherapy, and the survival of patients. However, hitherto, a comprehensive review aiming at relationship between lncRNAs and TIME is missing. In this review, we focus on the functional roles and molecular mechanisms of lncRNAs within the TIME. Furthermore, we discussed the potential immunotherapeutic strategies based on lncRNAs and their limitations.

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LncRNA MALAT1 promotes tumorigenesis and immune escape of diffuse large B cell lymphoma by sponging miR-195

Cited by 138 publications

References 38 publications

ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways

ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways

Long Non-coding RNAs: Emerging Roles in the Immunosuppressive Tumor Microenvironment

Long noncoding RNA: a dazzling dancer in tumor immune microenvironment

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