LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer

Huang, Xian-Xia; Liu, Xuemei; Du, Bo; Li, Xueling; Xue, Mei; Yan, Qingxin; Wang, Xiaohong; Wang, Qin

doi:10.18632/aging.202565

Cited by 33 publications

(20 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LINC01305 has been shown to regulate the target gene HTR3A mRNA through interaction with IGF2BP2 and IGF2BP3, thereby participating in the metastasis and proliferation of esophageal squamous cell carcinoma ( Huang et al, 2021a ). LINC01305 can mediate the RNA-binding protein KHSRP and activate the Wnt signaling pathway through upregulation of β-linked protein, TCF7, and CCND2, thereby participating in CC cell stemness ( Huang et al, 2021b ). Chen et al constructed a cervical cancer prognosis model based on immune-associated lncRNAs, wherein AL441992.1 was a protective factor in cervical cancer, which was consistent with our research ( Chen et al, 2020a ).…”

Section: Discussionmentioning

confidence: 99%

Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

et al. 2022

View full text Add to dashboard Cite

Background: Given the high incidence and high mortality of cervical cancer (CC) among women in developing countries, identifying reliable biomarkers for the prediction of prognosis and therapeutic response is crucial. We constructed a prognostic signature of cuproptosis-related long non-coding RNAs (lncRNAs) as a reference for individualized clinical treatment.Methods: A total of seven cuproptosis-related lncRNAs closely related to the prognosis of patients with CC were identified and used to construct a prognostic signature via least absolute shrinkage and selection operator regression analysis in the training set. The predictive performance of the signature was evaluated by Kaplan–Meier (K-M) analysis, receiver operating characteristic (ROC) analysis, and univariate and multivariate Cox analyses. Functional enrichment analysis and single-sample gene set enrichment analysis were conducted to explore the potential mechanisms of the prognostic signature, and a lncRNA–microRNA–mRNA network was created to investigate the underlying regulatory relationships between lncRNAs and cuproptosis in CC. The associations between the prognostic signature and response to immunotherapy and targeted therapy were also assessed. Finally, the prognostic value of the signature was validated using the CC tissues with clinical information in my own center.Results: A prognostic signature was developed based on seven cuproptosis-related lncRNAs, including five protective factors (AL441992.1, LINC01305, AL354833.2, CNNM3-DT, and SCAT2) and two risk factors (AL354733.3 and AC009902.2). The ROC curves confirmed the superior predictive performance of the signature compared with conventional clinicopathological characteristics in CC. The ion transport-related molecular function and various immune-related biological processes differed significantly between the two risk groups according to functional enrichment analysis. Furthermore, we discovered that individuals in the high-risk group were more likely to respond to immunotherapy and targeted therapies including trametinib and cetuximab than those in the low-risk group. Finally, CC tissues with clinical data from my own center further verify the robustness of the seven-lncRNA risk signature.Conclusion: We generated a cuproptosis-related lncRNA risk signature that could be used to predict prognosis of CC patients. Moreover, the signature could be used to predict response to immunotherapy and chemotherapy and thus could assist clinicians in making personalized treatment plans for CC patients.

show abstract

Section: Discussionmentioning

confidence: 99%

Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Exosomal miR-663b promotes EMT and metastasis in CC cells by targeting MGAT3 under TGF-β1 stimulation [58]. LncRNAs have also been found in exosomes, and exosomal lncRNA UCA1 from CC stem cells promotes self-renewal and differentiation of CC stem cells through the miRNA-122-5p/SOX2 axis [59]; exosomes from cancer cells produce lncRNA AGAP2-AS1, which regulates the miR-3064-5p/SIRT1 axis to boost the proliferation of CC cells [60]; LncRNA LINC01305 can also be transferred to recipient cells via exosomes in order to enhance CC progression [61].…”

Section: Exosomes Derived From Cellsmentioning

confidence: 99%

Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies

Miao

Zhu

et al. 2022

Cancers

View full text Add to dashboard Cite

Background: Exosomes are extracellular vesicles that can be released by practically all types of cells. They have a diameter of 30–150 nm. Exosomes control the exchange of materials and information between cells. This function is based on its special cargo-carrying and transporting functions, which can load a variety of useful components and guarantee their preservation. Recently, exosomes have been confirmed to play a significant role in the pathogenesis, diagnosis, treatment, and prognosis of gynaecological malignancies. Particularly, participation in liquid biopsy was studied extensively in gynaecological cancer, which holds the advantages of noninvasiveness and individualization. Literature Review: This article reviews the latest research progress of exosomes in gynaecological malignancies and discusses the involvement of humoral and cell-derived exosomes in the pathogenesis, progression, metastasis, drug resistance and treatment of ovarian cancer, cervical cancer, and endometrial cancer. Advances in the clinical application of exosomes in diagnostic technology, drug delivery, and overcoming tumour resistance are also presented. Conclusion: Exosomes are potentially diagnostic and prognostic biomarkers in gynaecological malignancies, and also provide new directions for the treatment of gynaecological tumours, showing great clinical potential.

show abstract

“…In vivo experiments showed that there was increased tumor growth in mice treated with these exosomes. In addition, the authors reported that co-culturing LINC01305-enriched exosomes with C-33 A cells generated an increase in β-catenin, TCF7, and CCND2 protein expression, suggesting that Wnt signaling may be associated with the LINC01305 effect [ 66 ].…”

Section: Rna In Extracellular Vesiclesmentioning

confidence: 99%

Extracellular Vesicles in Cervical Cancer and HPV Infection

et al. 2021

View full text Add to dashboard Cite

Since their description, extracellular vesicles (EVs) have shown growing relevance in cancer progression. These cell structures contain and transfer molecules such as nucleic acids (including DNA and RNA), proteins, and lipids. Despite the rising information about EVs’ relationship with cancer, there is still scarce evidence about their content and function in cervical cancer. Interestingly, the composition and purposes of some cellular molecules and the expression of oncogenic proteins packaged in EVs seem modified in HPV-infected cells; and, although only the E6 oncogenic protein has been detected in exosomes from HPV-positive cells, both E6/E7 oncogenes mRNA has been identified in EVs; however, their role still needs to be clarified. Given that EVs internalizing into adjacent or distant cells could modify their cellular behavior or promote cancer-associated events like apoptosis, proliferation, migration, or angiogenesis in receptor cells, their comprehensive study will reveal EV-associated mechanisms in cervical cancer. This review summarizes the current knowledge in composition and functions of cervical cancer and HPV Infection-derived EVs.

show abstract

LncRNA LINC01305 promotes cervical cancer progression through KHSRP and exosome-mediated transfer

Cited by 33 publications

References 50 publications

Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer

Advances in Exosomes as Diagnostic and Therapeutic Biomarkers for Gynaecological Malignancies

Extracellular Vesicles in Cervical Cancer and HPV Infection

Contact Info

Product

Resources

About