LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1

Deng, Xiaolei; Xiong, Wei; Jiang, Xianjie; Zhang, Shanshan; Li, Zheng; Zhou, Yanhong; Xiang, Bo; Zhou, Ming; Li, Xiaoling; Li, Guiyuan; Zeng, Zhaoyang; Gong, Zhaojian

doi:10.1038/s41419-020-03147-9

Cited by 72 publications

(51 citation statements)

References 55 publications

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“…Some genes have not been well-documented, whereas the remainder play different roles and their downregulation may cause pathogenic effects on the kidney. For example, FPGT, PDK1, and MMAA encode proteins important in cell metabolism, and STEAP1 and LINC00472 are associated with cancer development (Table S5B) [53,54]. While our results uncover some clues about the effects of SARS-CoV-2 on kidney cells, we must bear in mind that HEK 293T cells and kidney cells are not equivalent, and the actual responses of kidney cells to SARS-CoV-2 still need to be verified.…”

Section: Discussionmentioning

confidence: 86%

Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells

Nour

Tran

Afravi

et al. 2021

Preprint

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In 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged, causing the COVID-19 pandemic. Consequently, ongoing research has focused on better understanding the mechanisms underlying the symptoms of this disease. Although COVID-19 symptoms span a range of organ systems, the specific changes in gene regulation that lead to the variety of symptoms are still unclear. In our study, we used publicly available transcriptome data from previous studies on SARS-CoV-2 to identify commonly regulated genes across cardiomyocytes, human bronchial epithelial cells, alveolar type II cells, lung adenocarcinoma, human embryonic kidney cells, and patient samples. Additionally, using this common "core" transcriptome, we could identify the genes that were specifically and uniquely differentially regulated in bronchial epithelial cells, embryonic kidney cells, or cardiomyocytes. For example, we found that genes related to cell metabolism were uniquely upregulated in kidney cells, providing us with the first mechanistic clue about specifically how kidney cells may be affected by SARS-CoV-2. Overall, our results uncover connections between the differential gene regulation in various cell types in response to the SARS-CoV-2 infection and help identify targets of potential therapeutics.

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Section: Discussionmentioning

confidence: 86%

Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells

Nour

Tran

Afravi

et al. 2021

Preprint

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“…A hypoxic environment can activate VEGF [53], which binds to its receptor VEGFR-2 through an autocrine or paracrine mode, and activates JAK2/STAT3 to stimulate the stem transcription factors c-Myc and Sox-2. Thus, they can regulate CSC differentiation, survival, proliferation, and migration [102,103]. VEGF expression in melanoma is reported to promote the development of VM through activation of the PI3K/ AKT pathway in the tumor microenvironment [104].…”

Section: Hypoxia Promotes Cancer Stem Cell Differentiation Into An Enmentioning

confidence: 99%

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

et al. 2021

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Background Vasculogenic mimicry (VM) is a recently discovered angiogenetic process found in many malignant tumors, and is different from the traditional angiogenetic process involving vascular endothelium. It involves the formation of microvascular channels composed of tumor cells; therefore, VM is considered a new model for the formation of new blood vessels in aggressive tumors, and can provide blood supply for tumor growth. Many studies have pointed out that in recent years, some clinical treatments against angiogenesis have not been satisfactory possibly due to the activation of VM. Although the mechanisms underlying VM have not been fully elucidated, increasing research on the soil “microenvironment” for tumor growth suggests that the initial hypoxic environment in solid tumors is inseparable from VM. Main body In this review, we describe that the stemness and differentiation potential of cancer stem cells are enhanced under hypoxic microenvironments, through hypoxia-induced epithelial-endothelial transition (EET) and extracellular matrix (ECM) remodeling to form the specific mechanism of vasculogenic mimicry; we also summarized some of the current drugs targeting VM through these processes, suggesting a new reference for the clinical treatment of tumor angiogenesis. Conclusion Overall, the use of VM inhibitors in combination with conventional anti-angiogenesis treatments is a promising strategy for improving the effectiveness of targeted angiogenesis treatments; further, considering the importance of hypoxia in tumor invasion and metastasis, drugs targeting the hypoxia signaling pathway seem to achieve good results.

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“…Lung cancer (LC) can be divided into two subtypes: small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC), among which NSCLC accounts for the majority of LC cases [99]. Lambrechts et al [100] analyzed 92,948 NSCLC cells (84,341 stromal cells) at single-cell resolution, and identified 52 subtypes of stromal cells, providing a comprehensive list of stromal cell types.…”

Section: Highlighting Intra-and Inter-tumoral Heterogeneitymentioning

confidence: 99%

What are the applications of single-cell RNA sequencing in cancer research: a systematic review

Xiong

Wang

et al. 2021

J Exp Clin Cancer Res

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Single-cell RNA sequencing (scRNA-seq) is a tool for studying gene expression at the single-cell level that has been widely used due to its unprecedented high resolution. In the present review, we outline the preparation process and sequencing platforms for the scRNA-seq analysis of solid tumor specimens and discuss the main steps and methods used during data analysis, including quality control, batch-effect correction, normalization, cell cycle phase assignment, clustering, cell trajectory and pseudo-time reconstruction, differential expression analysis and gene set enrichment analysis, as well as gene regulatory network inference. Traditional bulk RNA sequencing does not address the heterogeneity within and between tumors, and since the development of the first scRNA-seq technique, this approach has been widely used in cancer research to better understand cancer cell biology and pathogenetic mechanisms. ScRNA-seq has been of great significance for the development of targeted therapy and immunotherapy. In the second part of this review, we focus on the application of scRNA-seq in solid tumors, and summarize the findings and achievements in tumor research afforded by its use. ScRNA-seq holds promise for improving our understanding of the molecular characteristics of cancer, and potentially contributing to improved diagnosis, prognosis, and therapeutics.

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LncRNA LINC00472 regulates cell stiffness and inhibits the migration and invasion of lung adenocarcinoma by binding to YBX1

Cited by 72 publications

References 55 publications

Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells

Identifying The “Core” Transcriptome of SARS-CoV-2 Infected Cells

Mechanisms of vasculogenic mimicry in hypoxic tumor microenvironments

What are the applications of single-cell RNA sequencing in cancer research: a systematic review

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