LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6

Kong, Yonggang; Cui, Min; Chen, Shiming; Xu, Yu; Xu, Yong; Tao, Zezhang

doi:10.1016/j.gene.2017.10.006

Cited by 104 publications

(110 citation statements)

References 35 publications

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“…Among these increased lncRNAs, we found that DUXAP8 and LINC00460 are consistently upregulated in TCGA data and three GEO datasets (Figure 4A,B). Interestingly, DUXAP8 has also been reported to be overexpressed in human non small cell lung cancer,24 gastric cancer25 and renal cell carcinoma,26 while LINC00460 expression is upregulated in nasopharyngeal carcinoma27 and promotes carcinogenesis in ESCC 28. Therefore, we chose these two lncRNAs for further analyses and validation.…”

Section: Resultsmentioning

confidence: 99%

“…As well as our findings, Sun et al24 reported that DUXAP8 promotes cell proliferation and invasion through repressing EGR1 and RHOB expression in human non small cell lung cancer; Ma et al25 found that DUXAP8 promotes cell proliferation through epigenetically silencing PLEKHO1 expression in gastric cancer. In addition, Kong and colleagues27 revealed that LINC00460 facilitates tumorigenesis by sponging miR‐149‐5p to up‐regulate IL6 in nasopharyngeal carcinoma; Liang et al28 reported that LINC00460 expression is upregulated in ESCC tissues and positively correlated with lymph node metastasis. Similarly, we also found that knockdown of DUXAP8 could impair esophageal cancer cells proliferation and invasion, and DUXAP8 expression is positively related to oncogenes MAGEA4 and GABRA3 expression, but negatively related to tumor suppressors INPP5A and TIMP4.…”

Section: Discussionmentioning

confidence: 99%

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A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

et al. 2018

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Esophageal cancer is one of the most common cancers and a leading cause of cancer‐related death worldwide. However, the mechanism of esophageal cancer pathogenesis remains poorly understood. Long noncoding RNAs (lncRNAs) dysregulation have been reported to involve in various human cancers, which highlights the potential of lncRNAs used as novel biomarkers for cancer diagnosis. Although more efforts have been made to identify novel lncRNAs signature in esophageal cancer, the expression pattern, prognostic value, and biological function of most lncRNAs in esophageal cancer still need to be systematically investigated. In this study, we comprehensively analyzed the expression profile of lncRNAs in more than 200 esophageal cancer patients tissue samples from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). We identified thousands of lncRNAs are differentially expressed in esophageal cancer tissues, and many of those lncRNAs expression are associated with patients overall survival or recurrence‐free survival time. Moreover, copy number variation analyses revealed that genomic loci copy number amplification or deletion might contribute to these lncRNAs dysregulation. Among these lncRNAs, DUXAP8 and LINC00460 were significantly upregulated, and GO enrichment analyses indicated that the two lncRNAs associated protein‐coding genes involve with many known biological processes, such as cell cycle and cell‐cell adherens junction. Further experimental validation revealed that knockdown of DUXAP8 could impair esophageal cancer cells proliferation and invasion in vitro. Taken together, our findings identified more aberrantly expressed lncRNAs in esophageal cancer that may provide a useful resource for identifying novel esophageal cancer associated lncRNAs.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

et al. 2018

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“…LINC00460, located at chromosome 13q33.2, has been reported to be closely associated with progression in several types of cancers. For instance, LINC00460 promoted nasopharyngeal carcinoma tumorigenesis through regulating miR‐149‐5p/IL6 signal pathway (Kong et al, ). LINC00460 promoted cell migration and invasion, and induces epithelial–mesenchymal transition in non‐small‐cell lung cancer by regulating hnRNPK (Peng et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC00460 promotes carcinogenesis via sponging miR‐613 in papillary thyroid carcinoma

Yang

Tang

2018

Journal Cellular Physiology

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Long intergenic noncoding RNA 460 (LINC00460) has been identified as a critical regulator for multiple types of cancers. However, the biological role and underlying mechanism in human papillary thyroid carcinoma (PTC) still remain unclear and need to be uncovered. This study was aimed to ascertain the biological role and molecular mechanism of LINC00460 in PTC progression. Our findings revealed that the level of LINC00460 was significantly upregulated in PTC tissues and cell lines, which was positively correlated with advanced tumor–node–metastasis (TNM) stage and lymph node metastasis. Cellular experiments exhibited that knockdown of LINC00460 decreased proliferative, migratory, and invasive abilities of PTC cells. Mechanism assays noted that knockdown of LINC00460 suppressed cell proliferation, migration, and invasion, and inhibited expression of sphingosine kinase 2 (SphK2, a target of miR‐613) in PTC cells, at least in part, by regulating miR‐613. These findings suggested that LINC00460 could function as a competing endogenous RNA to regulate SphK2 expression by sponging miR‐613 in PTC. Targeting LINC00460 could be a promising therapeutic strategy for patients with PTC.

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“…25,26 In addition, miR-149 was demonstrated to suppress cell invasive and migratory potentials in different types of cancers. [27][28][29] Our findings revealed miR-149 as a target for ZEB2-AS1. ZEB2-AS1 silence induced miR-149 F I G U R E 5 The correlation between ZEB2-AS1 expression levels and miR-149/PGF mRNA expression levels in placental tissues.…”

Section: Discussionmentioning

confidence: 94%

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axis

Gao

Sha

et al. 2019

J of Cellular Biochemistry

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Pre‐eclampsia (PE) is a pregnancy disease that causes maternal death and threatens the health of newborns. Accumulating evidence has revealed the essential roles of long noncoding RNAs (lncRNAs) in the progression of PE. The present investigation determined lncRNA ZEB2 antisense RNA 1 (ZEB2‐AS1) expression in PE and looked into the potential role of ZEB2‐AS1 in modulating trophoblastic cell functions. Quantitative real‐time polymerase chain reaction evaluated gene expression. Western blot analyzed the placental growth factor (PGF) protein level. Cell counting kit‐8 and Transwell invasion assays assessed the proliferative and invasive abilities of placental trophoblast cells, respectively. Wound healing assay determined cell migratory potentials. Dual‐luciferase reporter assay assessed the targeting relationship among ZEB2‐AS1, miR‐149, and PGF. Downregulation of lncRNA ZEB2‐AS1 was detected in placentas from patients with PE when compared with those from normal pregnancies. Moreover, ZEB2‐AS1 upregulation markedly promoted proliferative, migratory, and invasive potentials in HTR‐8/SVneo cells, while knockdown of ZEB2‐AS1 had the opposite effects. The effects on HTR‐8/SVneo cells mediated by ZEB2‐AS1 was correlated with the miR‐149/PGF axis. These findings indicate that ZEB2‐AS1 contributes to PE progression by affecting cell proliferative and invasive capacities via the miR‐149/PGF axis in HTR‐8/SVneo cells. In sum, we identified that ZEB2‐AS1 was a novel aberrantly expressed lncRNA in the placentas of PE patients and lncRNA ZEB2‐AS1 modulated trophoblastic cell line HTR‐8/SVneo's proliferative and invasive potentials via targeting the miR‐149/PGF axis.

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LncRNA-LINC00460 facilitates nasopharyngeal carcinoma tumorigenesis through sponging miR-149-5p to up-regulate IL6

Cited by 104 publications

References 35 publications

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

A genome‐wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer

Long noncoding RNA LINC00460 promotes carcinogenesis via sponging miR‐613 in papillary thyroid carcinoma

The decreased lncRNA ZEB2‐AS1 in pre‐eclampsia controls the trophoblastic cell line HTR‐8/SVneo's invasive and migratory abilities via the miR‐149/PGF axis

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