lncRNA LINC000466 Predicts the Prognosis and Promotes the Progression of Triple‐negative Breast Cancer via Modulating miR‐539‐5p

Liu, Jiaqi; Yu, Heshan; Wei, Feifei; Cui, Haiyan; Yan, Ting; Li, Tong; Liu, Yanze; Chen, Jun

doi:10.1016/j.clbc.2022.01.011

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Therefore, we investigated the specific roles and mechanisms of LINC02568 in breast cancer. Many lncRNAs are implicated in breast cancer oncogenicity, e.g., MAFG-AS1 [25], LINC00466 [26], and LINC00649 lncRNAs [27] are overexpressed in breast cancer, exerting pro-oncogenic effects. Conversely, low LINC00982 [28], SLC16A1-AS1 [29], and EPB41L4A-AS1 lncRNA levels [30] are reported to be associated with antioncogenic functions in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Dong¹,

ZHANG²,

Guan³

et al. 2021

Oncology Research

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Increasing numbers of long noncoding RNAs (lncRNAs) are implicated in breast cancer oncogenicity. However, the contribution of LINC02568 toward breast cancer progression remains unclear and requires further investigation. Herein, we evaluated LINC02568 expression in breast cancer and clarified its effect on disease malignancy. We also investigated the mechanisms underlying the pro-oncogenic role of LINC02568. Consequently, LINC02568 was upregulated in breast cancer samples, with a notable association with worse overall survival. Functionally, depleted LINC02568 suppressed cell proliferation, colony formation, and metastasis, whereas LINC02568 overexpression exerted the opposite effects. Our mechanistic investigations suggested that LINC02568 was physically bound to and sequestered microRNA-874-3p (miR-874-3p). Furthermore, miR-874-3p mediated suppressive effects in breast cancer cells by targeting cyclin E1 (CCNE1).LINC02568 positively controlled CCNE1 expression by sequestering miR-874-3p. Rescue experiments revealed that increased miR-874-3p or decreased CCNE1 expression recovered cell growth and motility functions induced by LINC02568 in breast cancer cells. In conclusion, the tumor-promoting functions of LINC02568 in breast cancer cells were enhanced by sequestering miR-874-3p and consequently over-expressing CCNE1. Our data may facilitate the identification of novel therapeutic targets in clinical settings.

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Section: Discussionmentioning

confidence: 99%

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Dong¹,

ZHANG²,

Guan³

et al. 2021

Oncology Research

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“…Regarding the other lncRNAs on which these variants were mapped, LINC00592 has been demonstrated in several studies to play a role in various cancer types through transcription regulation [43,44]. Other lncRNAs identified as potentially involved in cancer include FRMD6-AS1 [45,46] and LINC00466 [47,48], which have also been shown to promote tumor growth in vivo alongside [49] LINC00877 [50], LINC01091 [51], NNT-AS1 [52][53][54], ZNF252P-AS1 [55], LZTS1-AS1 [56], and OTUD6B-AS1 [57,58]. Of particular significance is also the fact that the host gene of NNT-AS1, NNT, encodes an inner mitochondrial membrane protein and produces large amounts of NADPH.…”

Section: Impact Of Variants On the Functionality Of Lncrnasmentioning

confidence: 99%

Unveiling the Genetic Complexity of Teratozoospermia: Integrated Genomic Analysis Reveals Novel Insights into lncRNAs’ Role in Male Infertility

Kyrgiafini,

Giannoulis,

Chatziparasidou

et al. 2023

IJMS

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Male infertility is a global health issue, affecting over 20 million men worldwide. Genetic factors are crucial in various male infertility forms, including teratozoospermia. Nonetheless, the genetic causes of male infertility remain largely unexplored. In this study, we employed whole-genome sequencing and RNA expression analysis to detect differentially expressed (DE) long-noncoding RNAs (lncRNAs) in teratozoospermia, along with mutations that are exclusive to teratozoospermic individuals within these DE lncRNAs regions. Bioinformatic tools were used to assess variants’ impact on lncRNA structure, function, and lncRNA–miRNA interactions. Our analysis identified 1166 unique mutations in teratozoospermic men within DE lncRNAs, distinguishing them from normozoospermic men. Among these, 64 variants in 23 lncRNAs showed potential regulatory roles, 7 variants affected 4 lncRNA structures, while 37 variants in 17 lncRNAs caused miRNA target loss or gain. Pathway Enrichment and Gene Ontology analyses of the genes targeted by the affected miRNAs revealed dysregulated pathways in teratozoospermia and a link between male infertility and cancer. This study lists novel variants and lncRNAs associated for the first time with teratozoospermia. These findings pave the way for future studies aiming to enhance diagnosis and therapy in the field of male infertility.

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“…Furthermore, many studies have provided evidence supporting lncRNA dysregulation in breast cancer and their significant roles [11][12][13]. For instance, LRP11-AS1 [14], LINC000466 [15] and LINC00649 [16] are highly expressed in breast cancer cells and confirmed to be oncogenic lncRNAs. In contrast, the downregulation of MBNL1-AS1 [17] and LINC00921 [18] in breast cancer cells has been reported to exert antitumor activities.…”

Section: Introductionmentioning

confidence: 99%

Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1

ZHOU¹,

ZHANG²,

Guan³

et al. 2021

Oncology Research

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Long noncoding RNA PPP1R14B antisense RNA 1 (PPP1R14B-AS1) has emerged as a critical modulator of liver cancer and lung adenocarcinoma progression. However, the functional importance and biological relevance of PPP1R14B-AS1 in breast cancer remain unclear. Therefore, this study was designed to detect PPP1R14B-AS1 levels in breast cancer cells using qRT-PCR and elucidate the influence of PPP1R14B-AS1 on aggressive phenotypes.Furthermore, molecular events mediating the action of PPP1R14B-AS1 were characterized in detail. Functional experiments addressed the impacts of PPP1R14B-AS1 knockdown on breast cancer cells. In this study, PPP1R14B-AS1 was found to be overexpressed in breast cancer, exhibiting a close correlation with poor patient prognosis.Results also showed that breast cancer cell proliferation and motility were suppressed when PPP1R14B-AS1 was silenced. Mechanistically, PPP1R14B-AS1 acted as a competing endogenous RNA for microRNA-134-3p (miR-134-3p) in breast cancer cells. PPP1R14B-AS1 also increased LIM and SH3 protein 1 (LASP1) levels by imitating miR-134-3p in breast cancer cells. Rescue experiments further corroborated that the knockdown of miR-134-3p or an increase in LASP1 restored the aggressive malignant characteristics of breast cancer cells that were weakened by PPP1R14B-AS1 depletion. In summary, PPP1R14B-AS1 facilitated the oncogenicity of breast cancer cells by controlling the miR-134-3p/LASP1 axis. We believe that our findings may contribute to the development of precision therapy techniques in the field of breast cancer treatment.

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lncRNA LINC000466 Predicts the Prognosis and Promotes the Progression of Triple‐negative Breast Cancer via Modulating miR‐539‐5p

Cited by 5 publications

References 28 publications

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Long noncoding RNA LINC02568 sequesters microRNA-874-3p to facilitate malignancy in breast cancer cells via cyclin E1 overexpression

Unveiling the Genetic Complexity of Teratozoospermia: Integrated Genomic Analysis Reveals Novel Insights into lncRNAs’ Role in Male Infertility

Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1

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