LncRNA influence sequential steps of hepatocellular carcinoma metastasis

Lv, Enjun; Sheng, Jiaqi; Yu, Chengpeng; Rao, Dean; Huang, Wenjie

doi:10.1016/j.biopha.2021.111224

Cited by 28 publications

(18 citation statements)

References 123 publications

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“…In the last decade, considerable studies have identified that lncRNAs played critical roles in carcinogenesis and metastasis (Lv et al 2021 ; Yao et al 2019 ; Poursheikhani et al 2021 ). To data, the ceRNA hypothesis sparked new areas of lncRNA research on gene expression regulation, but some controversy still surrounded it (Tay et al 2011 ; Smillie et al 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

Zhou

Liu

et al. 2021

Mol Med

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Background Tongue squamous cell carcinoma (TSCC) ranks as the most prevalent malignancy in the oral cavity. TSCC patients with occult lymph node metastasis (OLNM) are thought to be at risk of worse outcome. However, regulatory mechanisms underlying OLNM remain less investigated. Methods In the present study, CASC18/miR-20a-3p/TGFB2 axis was identified and evaluated by bioinformatic and qRT-PCR analyses. Effects of CASC18 knockdown on cell migration and invasion were determined by wound healing and transwell assays. Western blot, ELISA, RNA pulldown and luciferase reporter assays were performed for mechanism verification. Results CASC18 was identified up-regulating in TSCC tumours, and especially in those from patients with OLNM. Importantly, we found higher CASC18 expression was positively correlated with the presence of OLNM and worse outcome of TSCC patients. Furthermore, we demonstrated that CASC18 knockdown repressed cell migration and invasion through inhibiting epithelial-mesenchymal transition, which could be partly rescued by miR-20a-3p inhibitor. Regarding the molecular mechanism, we further confirmed that CASC18 functioned as a ceRNA to sponge miR-20a-3p to enhanceTGFB2 expression and secretion. Conclusion In conclusion, we have reported a novel CASC18/miR-20a-3p/TGFB2 ceRNA axis in OLNM of TSCC. Our findings will contribute to a deeper understanding of the molecular mechanism of OLNM in TSCC, and facilitate the development of diagnostic methods for assisting treatment decision-making.

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Section: Discussionmentioning

confidence: 99%

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

Zhou

Liu

et al. 2021

Mol Med

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“…In the blood circulation, the HCC cells should be able to escape immune surveillance and upon reaching new site, they colonize and new TME provides condition for rapid proliferation of HCC cells. 133 , 134 β-catenin signaling enhances metastasis of HCC cells via upregulating pyruvate dehydrogenase kinase isoenzyme 1 (PDK1) to stimulate Warburg effect. As a tumor-suppressor, PARPγ coactivator-1α (PGC-1α) suppresses Wnt/β-catenin axis via upregulating PARPγ to impair PDK1 activation and suppress Warburg effect, leading to decreased HCC metastasis.…”

Section: Beta-catenin and Hepatocellular Carcinomamentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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“…It has been reported that lncRNAs could interact with DNAs, miRNAs or proteins, participating in a variety of biological and pathological cellular processes via regulating target gene expression at transcriptional, post-transcriptionally and translational levels [ 2 ]. Increasing numbers of studies have indicated that lncRNAs play key roles in tumorigenesis and may be used in the diagnosis of cancers [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Linc01133 contributes to gastric cancer growth by enhancing YES1-dependent YAP1 nuclear translocation via sponging miR-145-5p

Sun

Tian

et al. 2022

Cell Death Dis

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The long intergenic non-coding RNA linc01133 is reported to be oncogenic in various malignancies. However, the role and mechanism of linc01133 in regulating gastric cancer growth is still not clear. In the present study, we found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients. The expression of linc01133 was regulated by c-Jun and c-Fos collaboratively. In both in vitro and in vivo studies, linc01133 was shown to promote gastric cancer cell growth. Linc01133 localized in the cytoplasm and functioned as an endogenous competing RNA of miR-145-5p to upregulate the expression of YES1, which was proved to be the target gene of miR-145-5p. By promoting YES1-dependent YAP1 nuclear translocation, linc01133 upregulated the expression of the key cell cycle regulators CDK4, CDK6 and cyclin D1 to promote G1-S phase transition. Thus, our study unveiled the function and mechanism of linc01133 regulating cell cycle progression in gastric cancer.

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LncRNA influence sequential steps of hepatocellular carcinoma metastasis

Cited by 28 publications

References 123 publications

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

Association of CASC18/miR-20a-3p/TGFB2 ceRNA axis with occult lymph node metastasis in tongue squamous cell carcinoma

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Linc01133 contributes to gastric cancer growth by enhancing YES1-dependent YAP1 nuclear translocation via sponging miR-145-5p

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