LncRNA
            <i>AC245100.4</i>
            Binds HSP90 to Promote the Proliferation of Prostate Cancer

Cui, Rongjun; Liu, Chi; Lin, Ping; Xie, Hui; Wang, Wei; Zhao, Jiabin; Jiang, Shan; Shi, Jie; Yu, Xiuchong

doi:10.2217/epi-2020-0270

Cited by 21 publications

(21 citation statements)

References 28 publications

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“…It is well known that LncRNAs mainly act as ceRNA to backout the inhibiting effects of miRNAs on their downstream targets 19,20 . SNHG1 was also reported to regulate miR-199a-3p and miR-337-3p/AKT2 axis, leading to promotion in PCa cells 11,12 . However, recently studies revealed that RNA binding protein plays a crucial role in LncRNA regulating network.…”

Section: Discussionmentioning

confidence: 97%

“…LncRNA prostate cancer antigen 3 (PCA3) has been approved by the U.S. FDA as a marker for the diagnosis of PCa, and has also been included in "Guidelines for Diagnosis and Treatment of Urological Diseases in China" 18 , announcing tremendous potential of lncRNA as a biomarker for the diagnosis and treatment of PCa, which is worthy of indepth study. Although several studies have proved that SNHG1 promoted PCa proliferation via serving as "miRNA sponeges" 11,12 , the functions and potential mechanisms in PCa remains unclear. We identified lncRNA SNHG1 was overexpressed in prostate cancer tissues and cells, and associated with patient's clinical characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…The abnormal expression of lncRNAs have also been reported to contribute to tumorigenic processes of many human malignancies, including PCa 8,9 . In PCa, recent studies have revealed that LncRNA DLX6-AS1 enhances PCa Malignant Phenotype and Lymph Node Metastasis 10 , and LncRNA AC245100.4 promotes the proliferation of PCa through binding to HSP90 11 . Small nucleolar RNA host gene 1(SNHG1), a novel LncRNA, has shown to be aberrantly high expression and oncogenic characteristics in various cancers 12 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

Tan

Chen

et al. 2021

Cell Death Dis

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The interaction between LncRNA and RNA-binding protein (RBPs) plays an essential role in the regulation over the malignant progression of tumors. Previous studies on the mechanism of SNHG1, an emerging lncRNA, have primarily focused on the competing endogenous RNA (ceRNA) mechanism. Nevertheless, the underlying mechanism between SNHG1 and RBPs in tumors remains to be explored, especially in prostate cancer (PCa). SNHG1 expression profiles in PCa were determined through the analysis of TCGA data and tissue microarray at the RNA level. Gain- and loss-of-function experiments were performed to investigate the biological role of SNHG1 in PCa initiation and progression. RNA-seq, immunoblotting, RNA pull-down and RNA immunoprecipitation analyses were utilized to clarify potential pathways with which SNHG1 might be involved. Finally, rescue experiments were carried out to further confirm this mechanism. We found that SNHG1 was dominantly expressed in the nuclei of PCa cells and significantly upregulated in PCa patients. The higher expression level of SNHG1 was dramatically correlated with tumor metastasis and patient survival. Functionally, overexpression of SNHG1 in PCa cells induced epithelial–mesenchymal transition (EMT), accompanied by down-regulation of the epithelial marker, E-cadherin, and up-regulation of the mesenchymal marker, vimentin. Increased proliferation and migration, as well as accelerated xenograft tumor growth, were observed in SNHG1-overexpressing PCa cells, while opposite effects were achieved in SNHG1-silenced cells. Mechanistically, SNHG1 competitively interacted with hnRNPL to impair the translation of protein E-cadherin, thus activating the effect of SNHG1 on the EMT pathway, eventually promoting the metastasis of PCa. Our findings demonstrate that SNHG1 is a positive regulator of EMT activation through the SNHG1-hnRNPL-CDH1 axis. SNHG1 may serve as a novel potential therapeutic target for PCa.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

Tan

Chen

et al. 2021

Cell Death Dis

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show abstract

“…For example, BiP surface translocation is required for different cotransporters, such as DNAJC3 ( Vig et al, 2019 ), Par-4 ( Cohen et al, 2013 ), and MTJ-1 ( Misra et al, 2005 ), in a context-dependent manner. Recent studies have indicated that lncRNAs can directly interact with the molecular chaperone HSP90, regulating signaling or protein stability by altering chaperone function ( Guo et al, 2018 ; Cui et al, 2020 ). Our data indicated that lnc-LTR5B binds to BiP in the cytoplasm.…”

Section: Discussionmentioning

confidence: 99%

An Endogenous Retroviral LTR-Derived Long Noncoding RNA lnc-LTR5B Interacts With BiP to Modulate ALV-J Replication in Chicken Cells

Chen

Zhao

et al. 2021

Front. Microbiol.

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Infection with the avian leukosis virus subgroup J (ALV-J) impairs host genes and facilitates the establishment of chronic infection and the viral life cycle. However, the involvement of long noncoding RNAs (lncRNAs) in ALV-J infection remains largely unknown. In this study, we identified a novel chicken lncRNA derived from LTR5B of the ERV-L family (namely lnc-LTR5B), which is significantly downregulated in ALV-J infected cells. lnc-LTR5B was localized in the cytoplasm and was relatively high expressed in the chicken lung and liver. Notably, the replication of ALV-J was inhibited by the overexpression of lnc-LTR5B but enhanced when lnc-LTR5B expression was knocked down. We further confirmed that lnc-LTR5B could bind to the binding immunoglobulin protein (BiP), a master regulator of endoplasmic reticulum (ER) function. Mechanistically, lnc-LTR5B serves as a competing endogenous RNA for BiP, restricting its physical availability. Upon ALV-J infection, the reduction of lnc-LTR5B released BiP, which facilitated its translocation to the cell surface. This is crucial for ALV-J entry as well as pro-survival signaling. In conclusion, we identified an endogenous retroviral LTR-activated lnc-LTR5B that is involved in regulating the cell surface translocation of BiP, and such regulatory machinery can be exploited by ALV-J to complete its life cycle and propagate.

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“…On the contrary, a study conducted to determine the role of SNHG3 in breast cancer in a nude mouse model demonstrated that SNHG3 promotes cancer proliferation and metastasis by functioning as a miR-326 sponge [ 87 ]. The lncRNAs induce cancer invasion, proliferation, stemness, and metastasis by utilizing different mechanisms, i.e., by either promoting epithelial-to-mesenchymal transition (EMT) [ 88 ], regulating miRNAs expression profile via miRNAs sponging [ 89 ], modulating cell cycle including apoptotic pathways [ 90 ], interfering in mRNAs splicing [ 91 ], inducing resistance to different anti-cancer drugs [ 92 ], cellular metabolic reprogrammings [ 93 ], altering localization of proteins using direct binding [ 94 ], or regulating various associated metastatic signaling pathways [ 95 ].…”

Section: Lncrnas In Female-oriented Cancersmentioning

confidence: 99%

The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

Naz

Tariq

Ali

et al. 2021

Cancers

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Recent advances in molecular biology have discovered the mysterious role of long non-coding RNAs (lncRNAs) as potential biomarkers for cancer diagnosis and targets for advanced cancer therapy. Studies have shown that lncRNAs take part in the incidence and development of cancers in humans. However, previously they were considered as mere RNA noise or transcription byproducts lacking any biological function. In this article, we present a summary of the progress on ascertaining the biological functions of five lncRNAs (HOTAIR, NEAT1, H19, MALAT1, and MEG3) in female-oriented cancers, including breast and gynecological cancers, with the perspective of carcinogenesis, cancer proliferation, and metastasis. We provide the current state of knowledge from the past five years of the literature to discuss the clinical importance of such lncRNAs as therapeutic targets or early diagnostic biomarkers. We reviewed the consequences, either oncogenic or tumor-suppressing features, of their aberrant expression in female-oriented cancers. We tried to explain the established mechanism by which they regulate cancer proliferation and metastasis by competing with miRNAs and other mechanisms involved via regulating genes and signaling pathways. In addition, we revealed the association between stated lncRNAs and chemo-resistance or radio-resistance and their potential clinical applications and future perspectives.

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LncRNA AC245100.4 Binds HSP90 to Promote the Proliferation of Prostate Cancer

Cited by 21 publications

References 28 publications

LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

An Endogenous Retroviral LTR-Derived Long Noncoding RNA lnc-LTR5B Interacts With BiP to Modulate ALV-J Replication in Chicken Cells

The Role of Long Non-Coding RNAs (lncRNAs) in Female Oriented Cancers

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