LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosis

Zhao, Jie; Fan, Yonggang; Wang, Kunpeng; Ni, Xiao; Gu, Jian; Lü, Hao; Lu, Yunjie; Lü, Ling; Dai, Xinzheng; Wang, Xuehao

doi:10.1016/j.intimp.2015.04.028

Cited by 32 publications

(27 citation statements)

References 20 publications

(23 reference statements)

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“…However, HULC expression did not correlate with age, sex, embolus, or alpha‐fetoprotein. Previous studies have reported that HULC was induced by the viral HBx protein, but our data showed there was no association with hepatitis B virus (HBV) infection ( P = 1.000; Table ).…”

Section: Resultscontrasting

confidence: 73%

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance hepatocarcinogenesis

et al. 2017

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Section: Resultscontrasting

confidence: 73%

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance hepatocarcinogenesis

et al. 2017

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“…A recent study has reported that more than 3,600 lncRNAs are expressed at different levels in HSCs and that 400 lncRNAs are specifically expressed in HSC (37), suggesting that lncRNAs may play a key role in the progression of cirrhosis. The lncRNA HULC was found to be upregulated in plasma samples from patients with HBVrelated cirrhosis (38). The current study indicated that LINC RP-1130 tends to be expressed at lower levels in patients with cirrhosis than patients without cirrhosis, suggesting that some LncRNA expression profiles may change in patients with HCC and cirrhosis.…”

Section: Discussionmentioning

confidence: 56%

The significance of low levels of LINC RP1130-1 expression in human hepatocellular carcinoma

Xiao

Wang

Cheng³

et al. 2016

BST

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“…Long noncoding RNAs (lncRNAs) are important new members of the noncoding RNA family, which comprises RNAs longer than 200 bases that do not encode proteins [1]. To date, many lncRNAs have been found to play important roles in the genesis and progression of tumors [2].…”

Section: Introductionmentioning

confidence: 99%

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors

Wang¹,

Wang²,

Gao³

et al. 2018

Cell Physiol Biochem

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Background/Aims: Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer and could function as competing endogenous RNAs (ceRNAs) to regulate microRNAs (miRNAs). Methods: Quantitative real-time PCR (qRT-PCR) was used to analyze the expression of lnc-SNHG1 and miR-302/372/373/520 in pituitary tumor tissues and cell lines. Cell proliferation was investigated using MTT and cell count assays. The mechanisms by which lnc-SNHG1 affects pituitary tumor progression were investigated using Western blot assays, transwell migration assays, immunohistochemistry, immunofluorescence, luciferase reporter assays, tumor xenografts, and flow cytometry Results: We found that lnc-SNHG1 was overexpressed in invasive pituitary tumor tissues and cell lines. Ectopic expression of lnc-SNHG1 promoted cell proliferation, migration, and invasion, as well as the epithelial-mesenchymal transition (EMT), by affecting the cell cycle and cell apoptosis in vitro and tumor growth in vivo. Further study indicated that overexpression of lnc-SNHG1 markedly inhibited the expression of miR-302/372/373/520 (miRNA-pool) which is down-regulated in invasive pituitary tumor cells. Moreover, overexpression of lnc-SNHG1 significantly promoted the expression of TGFBR2 and RAB11A, the direct targets of miR-302/372/373/520. Finally, lnc-SNHG1 activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-catenin pathways in pituitary tumor cells via sponging miR-302/372/373/520. Conclusions: Our data suggest that lnc-SNHG1 promotes the progression of pituitary tumors and is a potential therapeutic target for invasive pituitary tumor.

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LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosis

Cited by 32 publications

References 20 publications

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance hepatocarcinogenesis

Long noncoding RNA HULC modulates the phosphorylation of YB‐1 through serving as a scaffold of extracellular signal–regulated kinase and YB‐1 to enhance hepatocarcinogenesis

The significance of low levels of LINC RP1130-1 expression in human hepatocellular carcinoma

Lnc-SNHG1 Activates the TGFBR2/SMAD3 and RAB11A/Wnt/β-Catenin Pathway by Sponging MiR-302/372/373/520 in Invasive Pituitary Tumors

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