lncRNA HOXA11-AS Promotes Proliferation and Migration via Sponging miR-155 in Hypopharyngeal Squamous Cell Carcinoma

Xu, Jianing; Bo, Qiyu; Zhang, Xiang; Lei, Dapeng; Wang, Jue; Pan, Xinliang

doi:10.3727/096504020x15801233454611

Cited by 15 publications

(17 citation statements)

References 45 publications

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“…For instance, lncRNA PEG10 was highly expressed in HSCC, and overexpression of lncRNA PEG10 facilitated cell proliferation and metastasis in vitro (29). HOXA11-AS was one of the most overexpressed lncRNAs in HSCC and positively associated with lymph node metastasis (30). HOXA11-AS1 was up-regulated in HSCC suggested by microarray analysis, we therefore chose HOXA11-AS1 as the present research object.…”

Section: Discussionmentioning

confidence: 99%

HOXA11-AS1 Promotes PD-L1 Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating the Association of PTBP1 with FOSL1

Zhang¹,

Liu²,

Zhang³

et al. 2022

SSRN Journal

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Section: Discussionmentioning

confidence: 99%

HOXA11-AS1 Promotes PD-L1 Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating the Association of PTBP1 with FOSL1

Zhang¹,

Liu²,

Zhang³

et al. 2022

SSRN Journal

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“…HOXA11-AS knockdown suppresses the proliferation and migration ability in HSCC FaDu cells by sponging miR-155. 35 Furthermore, HOXA11-AS also targets miR-518-3p and enhances PDK1 level, thus promoting the malignancy of OSCC both in vitro and in vivo. 36 …”

Section: Biological Roles Of Lncrnas In Hnsccmentioning

confidence: 99%

The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma

Jiang

Liu

Yang

et al. 2022

Molecular Therapy - Oncolytics

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Head and neck cancers are a heterogeneous collection of malignancies of the upper aerodigestive tract, salivary glands, and thyroid. However, the molecular mechanisms underlying the carcinogenesis of head and neck squamous cell carcinomas (HNSCCs) remain poorly understood. Over the past decades, overwhelming evidence has demonstrated the regulatory roles of long non-coding RNAs (lncRNAs) in tumorigenesis, including HNSCC. Notably, these lncRNAs have vital roles in gene regulation and affect various aspects of cellular homeostasis, including proliferation, survival, and metastasis. They exert regulating functions by interacting with nucleic acids or proteins and affecting cancer cell signaling. LncRNAs represent a burgeoning field of cancer research, and we are only beginning to understand the importance and complicity of lncRNAs in HNSCC. In this review, we summarize the deregulation and function of lncRNAs in human HNSCC. We also review the working mechanism of lncRNAs in HNSCC pathogenesis and discuss the potential application of lncRNAs as diagnostic/prognostic tools and therapeutic targets in human HNSCC.

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“…HOXA11-AS (NCRNA 00076), the antisense strand of the HOXA11 gene, regulates the growth and metastasis of cancer cells and is currently considered a cancer biomarker and therapeutic target ( Xue et al, 2018 ). Recently, HOXA11-AS has been recognized to hold application potential as a circulating biomarker for early detection of HSCC, which promoted HSCC development by sponge to tumor suppressor miR-155 ( Xu et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression

et al. 2022

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Hypopharyngeal squamous cell carcinoma (HSCC) is one of the high mortality cancers with a poor prognosis, which is driving the development of new chemotherapeutic agents. We identified the anticancer effects of a natural compound, solamargine (SM), on FaDU cells and explored its mechanism in terms of non-coding RNA. It was observed that SM inhibited the proliferation of FaDU cells with an IC50 of 5.17 μM. High-throughput sequencing data revealed that lncRNA HOXA11-AS was significantly downregulated in cells co-incubated with SM. Further assays demonstrated that SM-induced downregulation of lncRNA HOXA11-AS showed important implications for apoptosis. Given the properties of HOXA11-AS as a miR-155 sponge, we further confirmed that SM upregulated the expression of miR-155 in FaDU cells. C-Myc is a transcription factor that regulates cell differentiation and apoptosis, whose mRNA is considered to be targeted by miR-155. We showed that c-Myc expression was downregulated by SM and accompanied by increased apoptosis, which was consistent with the findings of transcriptome sequencing. Furthermore, SM administration suppressed xenograft tumor growth in a xenograft mouse model in vivo. In the light of the aforementioned findings, our results suggested that SM downregulated the expression of HOXA11-AS, which in turn induces apoptosis by downregulating c-Myc in FaDU, providing evidence for the anticancer effect of SM on HSCC and uncovering the effect of SM on non-coding RNAs as, at least partly, a mechanism of action.

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lncRNA HOXA11-AS Promotes Proliferation and Migration via Sponging miR-155 in Hypopharyngeal Squamous Cell Carcinoma

Cited by 15 publications

References 45 publications

HOXA11-AS1 Promotes PD-L1 Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating the Association of PTBP1 with FOSL1

HOXA11-AS1 Promotes PD-L1 Mediated Immune Escape and Metastasis of Hypopharyngeal Carcinoma by Facilitating the Association of PTBP1 with FOSL1

The role of long non-coding RNAs in the pathogenesis of head and neck squamous cell carcinoma

Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression

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