LncRNA HOXA-AS3 Promotes the Progression of Pulmonary Arterial Hypertension through Mediation of miR-675-3p/PDE5A Axis

Li, Zhongkui; Gao, Lufang; Zhu, Xian; Xiang, Dingcheng

doi:10.1007/s10528-021-10053-y

Cited by 15 publications

(17 citation statements)

References 44 publications

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“…Hoxa-AS3 exhibits a dual nuclear and cytoplasmic distribution in PASMCs. Apart from its regulating gene in cis as a nuclear lncRNA, Hoxa-AS3 can function as a ceRNA to sponge miR-675-3p by derepressing PDE5A expression in PASMCs [ 96 ].…”

Section: Long Noncoding Rnas (Lncrnas) In Pulmonary Hypertensionmentioning

confidence: 99%

The Landscape of Noncoding RNA in Pulmonary Hypertension

et al. 2022

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The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs in the noncoding transcriptome are long noncoding RNAs (lncRNAs) with less circular RNAs (circRNAs), which are two characteristics gaining increasing attention in the forefront of RNA research field. These noncoding transcripts (especially lncRNAs and circRNAs) exert important regulatory functions in PH and emerge as potential disease biomarkers and therapeutic targets. Recent technological advancements have established great momentum for discovery and functional characterization of ncRNAs, which include broad transcriptome sequencing such as bulk RNA-sequence, single-cell and spatial transcriptomics, and RNA-protein/RNA interactions. In this review, we summarize the current research on the classification, biogenesis, and the biological functions and molecular mechanisms of these noncoding RNAs (ncRNAs) involved in the pulmonary vascular remodeling in PH. Furthermore, we highlight the utility and challenges of using these ncRNAs as biomarkers and therapeutics in PH.

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Section: Long Noncoding Rnas (Lncrnas) In Pulmonary Hypertensionmentioning

confidence: 99%

The Landscape of Noncoding RNA in Pulmonary Hypertension

et al. 2022

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“…Recent evidence showed that the overexpression of HOXA-AS3 was revealed in various types of human diseases and pathophysiological processes, including liver cancer [23][24][25], glioma [26,27], lung cancer [28][29][30], oral cancer [31], colorectal cancer [32], gastric cancer [33], pancreatic cancer [34], endometriosis [35], atherosclerosis [36,37], pulmonary arterial hypertension [38], and the lineage differentiation of mesenchymal stem cells (MSCs) [39]. In addition, high HOXA-AS3 expression has been identified to correlate with unfavorable clinicopathological features and poor prognoses, such as pathological grade, TNM stage, tumor size, lymph node metastasis, invasion depth, and Helicobacter pylori infection status, overall survival, and disease-free survival (Table 1).…”

Section: The Expression Of Hoxa-as3 and Its Roles In Human Diseases A...mentioning

confidence: 99%

“…HOXA-AS3 was also overexpressed hypoxia-treated human pulmonary artery smooth muscle cells (HPASMCs), which was regarded as in vitro model of pulmonary arterial hypertension (PAH). Besides, HOXA-AS3 has been proved to promote proliferation and migration but repress the apoptosis of HPASMCs [ 38 ].…”

Section: Non-cancerous Diseasesmentioning

confidence: 99%

“…In osteogenic differentiation of MSCs, HOXA-AS3 regulated the lineage specification of MSC by combining with EZH2 and also influencing the H3 lysine-27 trimethylation of Runx2 [ 39 ]. Besides, HOXA-AS3 combined with miR-675-3p to elevate PDE5A levels, boosting the proliferation, migration, and anti-apoptosis of hypoxia-treated human pulmonary artery smooth muscle cells [ 38 ].…”

Section: Non-cancerous Diseasesmentioning

confidence: 99%

“…lncRNA HOXA Cluster Antisense RNA 3 (HOXA-AS3) is a newly discovered lncRNA with 25,952 bases and in the genomic location at human chromosome 7p15.2 started 900 nt downstream of the 3' end of HOXB5 [22]. HOXA-AS3 expression has been implicated in a variety of human diseases and pathophysiological processes, including liver cancer [23][24][25], glioma [26,27], lung cancer [28][29][30], oral cancer [31], colorectal cancer [32], gastric cancer [33], pancreatic cancer [34], endometriosis [35], atherosclerosis [36,37], pulmonary arterial hypertension [38,39], and even the lineage differentiation of mesenchymal stem cells (MSCs) [39], according to numerous studies. In these disorders, high HOXA-AS3 expression has been reported to closely relate to several clinicopathologic characteristics, such as pathological grade, TNM stage, tumor size, lymph node metastasis, invasion depth, and Helicobacter pylori infection status, overall survival, and disease-free survival.…”

Section: Introductionmentioning

confidence: 99%

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The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases

Yao

Wang

et al. 2022

Clin Transl Oncol

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Long non-coding RNA (lncRNA) is a non-protein-coding RNA with a length of more than 200 nucleotides. Studies have shown that lncRNAs have vital impacts on various pathological processes and participate in the development of human diseases, usually through acting as competing endogenous RNAs to modulate miRNA expression and biological functions. lncRNA HOXA Cluster Antisense RNA 3 (HOXA-AS3) was a newly discovered lncRNA and has been demonstrated to be abnormally expressed in many diseases. Moreover, HOXA-AS3 expression was closely correlated with the clinicopathologic characteristics in cancer patients. In addition, HOXA-AS3 exhibited significant properties in regulating several biological processes, including cell proliferation, invasion, and migration. Furthermore, HOXA-AS3 has provided promising values in the diagnosis, prognosis, and therapeutic strategies of several diseases such as liver cancer, glioma, lung cancer, oral cancer, gastric cancer, and even atherosclerosis. In this review, we discuss the abnormal expression of HOXA-AS3 in several human disorders and some pathobiological processes and its clinical characteristics, followed by a summary of HOXA-AS3 functions, regulatory mechanisms, and clinical application potential.

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Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis

Gao

Dong

et al. 2022

Human Cell

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LncRNA HOXA-AS3 Promotes the Progression of Pulmonary Arterial Hypertension through Mediation of miR-675-3p/PDE5A Axis

Cited by 15 publications

References 44 publications

The Landscape of Noncoding RNA in Pulmonary Hypertension

The Landscape of Noncoding RNA in Pulmonary Hypertension

The integrated comprehension of lncRNA HOXA-AS3 implication on human diseases

Long noncoding RNA MIR3142HG accelerates lipopolysaccharide-induced acute lung injury via miR-95-5p/JAK2 axis

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