lncRNA HOTAIR upregulates COX-2 expression to promote invasion and migration of nasopharyngeal carcinoma by interacting with miR-101

Hu, Weiqi; Xu, Weimin; Shi, Yi; Dai, Weigang

doi:10.1016/j.bbrc.2018.09.190

Cited by 21 publications

(13 citation statements)

References 26 publications

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“…Elevated cell migration and invasion are associated with the increased metastatic potential of cancer cells [21, 22], which may be independent of cell proliferation rates. Therefore, we studied the effect of USP3 on cell invasion and migration of MGC-803 (Low-level expression, Fig.…”

Section: Resultsmentioning

confidence: 99%

Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

Liu

Zhu

et al. 2019

J Exp Clin Cancer Res

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Background The deubiquitinating enzyme ubiquitin-specific protease 3 (USP3) plays a crucial role in numerous biological processes. The aberrant expression of USP3 may have an important role in tumor development. However, the mechanism by which USP3 promotes gastric cancer (GC) metastasis remains largely unknown. Methods Effects of USP3 on the progression of GC in vivo and in vitro and the potential underlying mechanisms have been investigated utilizing proteomics, RT-PCR, western blotting, immunohistochemistry, immunofluorescence, cell invasion and migration assays and xenograft tumor models. Results USP3 expression was upregulated in GC compared with matched normal tissues and was predictive of poor survival. USP3 also promoted migration and epithelial-to-mesenchymal transition (EMT) in GC cells. Moreover, TGF-β1 induced USP3 expression, and USP3 knockdown inhibited TGF-β1-induced EMT. Furthermore, we utilized Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) to identify differentially expressed proteins in USP3-overexpressing cells compared with control cells. Importantly, we found that SUZ12 is indispensable for USP3-mediated oncogenic activity in GC. We observed that USP3 interacted with and stabilized SUZ12 via deubiquitination. SUZ12 knockdown inhibited USP3-induced migration and invasion, as well as EMT in GC cells. Examination of clinical samples confirmed that USP3 expression was positively correlated with SUZ12 protein expression and that the levels of USP3 or SUZ12 protein were negatively correlated with the levels of E-cadherin protein. Conclusions These findings identify USP3 as a critical regulator. The USP3-SUZ12 axis might promote tumor progression and could be a potential therapeutic candidate for human GC. Electronic supplementary material The online version of this article (10.1186/s13046-019-1270-4) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

Liu

Zhu

et al. 2019

J Exp Clin Cancer Res

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“…Aberrantly expressed lncRNAs were widely reported to be related with tumorigenesis and the development of various cancers, including NPC. 17,23,24 For instance, Zheng et al 25 demonstrated that the lncRNA FAM225A promotes NPC tumorigenesis and metastasis by acting as competing endogenous RNA to sponge miR-590-3p/miR-1275 and upregulate integrin beta chain beta 3 (ITGB3). In contrast, a recent study by Zhang et al 26 revealed that the lncRNA NKILA represses the carcinogenesis and metastasis of NPC by NF-kB pathway inhibition.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma

Jiang

Zhong

et al. 2020

The American Journal of Pathology

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“…Our future study will further investigate the roles of DRHC in regulating TNBC cell invasion and migration. Additionally, lncRNA DRHC may interact with multiple downstream effectors to achieve a fine regulation of cancer cell behaviors (18).…”

Section: Discussionmentioning

confidence: 99%

Long non‑coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non‑coding RNA HOTAIR

Wang

Zhang³

2019

Oncol Lett

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Long non-coding RNA (lncRNA) downregulated in hepatocellular carcinoma (DRHC) is a tumor suppressor in liver cancer. However, the role of this lncRNA in breast cancer has not been investigated. The present study revealed that lncRNA DRHC was downregulated and lncRNA Hox transcript antisense RNA (HOTAIR) was upregulated in tumor tissues compared with adjacent healthy tissues in patients with triple negative breast cancer (TNBC). Expression levels of lncRNA DRHC and lncRNA HOTAIR were negatively correlated in tumor tissues but not in adjacent healthy tissues. The lncRNA DRHC expression level was correlated with tumor size but not tumor metastasis. In vitro overexpression of lncRNA DRHC in TNBC cell lines resulted in decreased expression of lncRNA HOTAIR; however, lncRNA HOTAIR overexpression did not affect the expression level of lncRNA DRHC. Overexpression of lncRNA DRHC inhibited, while overexpression of lncRNA HOTAIR promoted the proliferation of the TNBC cell lines. In addition, lncRNA HOTAIR overexpression attenuated the inhibitory effects of lncRNA DRHC overexpression on cancer cell proliferation. The results obtained in the current study suggested that lncRNA DRHC may inhibit the proliferation of TNBC cells by downregulating the expression of lncRNA HOTAIR.

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lncRNA HOTAIR upregulates COX-2 expression to promote invasion and migration of nasopharyngeal carcinoma by interacting with miR-101

Cited by 21 publications

References 26 publications

Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer

Long Noncoding RNA DANCR Regulates Cell Proliferation by Stabilizing SOX2 mRNA in Nasopharyngeal Carcinoma

Long non‑coding RNA DRHC inhibits the proliferation of cancer cells in triple negative breast cancer by downregulating long non‑coding RNA HOTAIR

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