LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1

Guo, Shanchun; King, Pendelton; Liang, Emily C.; Guo, Alyssa; Liu, Mingli

doi:10.1016/j.cellsig.2022.110306

Cited by 18 publications

(20 citation statements)

References 59 publications

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“…In addition, FOSL1 also mediates the dephosphorylation of proliferation and apoptosis bridging protein 15 (PEA15) by upregulating dual-specificity phosphatase 7 (DUSP7), which increases drug resistance in breast cancer ( Li et al, 2022b ). It is to be noted that FOSL1 was also associated with glioma growth and invasion and was a poor prognostic factor for GBM ( Guo et al, 2022 ). Gliomas overexpress FRA1, which regulates the malignancy of gliomas, including morphology, growth pattern, and tumorigenic potential ( Debinski and Gibo, 2005 ).…”

Section: Discussionmentioning

confidence: 99%

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

Wang

Liu

et al. 2022

Front. Genet.

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To determine the relationship between glioma and muscle aging and to predict prognosis by screening for co-expressed genes, this study examined the relationship between glioma and sarcopenia. The study identified eight co-downregulated miRNAs, three co-upregulated miRNAs, and seven genes associated with overall glioma survival, namely, KRAS, IFNB1, ALCAM, ERBB2, STAT3, FOSL1, and EN2. With a multi-factor Cox regression model incorporating FOSL1 and EN2, we obtained ROC curves of 0.702 and 0.709, respectively, suggesting that glioma prognosis can be predicted by FOSL1 and EN2, which are differentially expressed in both cancer and aged muscle. FOSL1 and EN2 were analyzed using Gene Set Enrichment Analysis to identify possible functional pathways. RT-qPCR and a dual-luciferase reporter gene system verified that hsa-miR-33a targets FOSL1 and EN2. We found that hsa-mir-33a co-targeting FOSL1 and EN2 has a good predictive value for glioblastoma and skeletal muscle reduction.

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Section: Discussionmentioning

confidence: 99%

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

Wang

Liu

et al. 2022

Front. Genet.

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“…miR-301a-3p may represent another sponging target of HOTAIR in gliomas, and inhibition of miR-301a-3p mediated by HOTAIR has been reported to cause induction of the expression of transcription factor, Fos-like 1 (FOSL1) (Ref. 77). The miR-126-5p–glutaminase (GLS) axis is yet another target of HOTAIR in the pathogeneses of gliomas.…”

Section: Hotair In Brain (Patho)physiologymentioning

confidence: 99%

The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget

Ahmad,

Sudesh,

Ahmed

et al. 2024

Expert Rev. Mol. Med.

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Long non-coding RNAs (lncRNAs) are progressively being perceived as prominent molecular agents controlling multiple aspects of neuronal (patho)physiology. Amongst these is the HOX transcript antisense intergenic RNA, often abbreviated as HOTAIR. HOTAIR epigenetically regulates its target genes via its interaction with two different chromatin-modifying agents; histone methyltransferase polycomb-repressive complex 2 and histone demethylase lysine-specific demethylase 1. Parenthetically, HOTAIR elicits trans-acting sponging function against multiple micro-RNA species. Oncological research studies have confirmed the pathogenic functions of HOTAIR in multiple cancer types, such as gliomas and proposed it as a pro-oncological lncRNA. In fact, its expression has been suggested to be a predictor of the severity/grade of gliomas, and as a prognostic biomarker. Moreover, a propound influence of HOTAIR in other aspects of brain heath and disease states is just beginning to be unravelled. The objective of this review is to recapitulate all the relevant data pertaining to the regulatory roles of HOTAIR in neuronal (patho)physiology. To this end, we discuss the pathogenic mechanisms of HOTAIR in multiple neuronal diseases, such as neurodegeneration, traumatic brain injury and neuropsychiatric disorders. Finally, we also summarize the results from the studies incriminating HOTAIR in the pathogeneses of gliomas and other brain cancers. Implications of HOTAIR serving as a suitable therapeutic target in neuropathologies are also discussed.

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“…Overexpression of miR-28-5p suppressed glioma cells’ proliferation and invasion, by upregulating the target Rap1b gene ( 313 ). In addition, TRPM7 knockout in A172 glioma cells induced the regulation of a series of lncRNAs ( 318 ), of which HOX transcript antisense intergenic RNA (HOTAIR) was the most positively affected by TRPM7 depletion ( 319 ). TRPM7-mediated HOTAIR overexpression promoted glioma cell proliferation and invasion.…”

Section: Trpm Channels: Characteristics and Functionsmentioning

confidence: 99%

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications

et al. 2023

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The transient melastatin receptor potential (TRPM) ion channel subfamily functions as cellular sensors and transducers of critical biological signal pathways by regulating ion homeostasis. Some members of TRPM have been cloned from cancerous tissues, and their abnormal expressions in various solid malignancies have been correlated with cancer cell growth, survival, or death. Recent evidence also highlights the mechanisms underlying the role of TRPMs in tumor epithelial-mesenchymal transition (EMT), autophagy, and cancer metabolic reprogramming. These implications support TRPM channels as potential molecular targets and their modulation as an innovative therapeutic approach against cancer. Here, we discuss the general characteristics of the different TRPMs, focusing on current knowledge about the connection between TRPM channels and critical features of cancer. We also cover TRPM modulators used as pharmaceutical tools in biological trials and an indication of the only clinical trial with a TRPM modulator about cancer. To conclude, the authors describe the prospects for TRPM channels in oncology.

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LncRNA HOTAIR sponges miR-301a-3p to promote glioblastoma proliferation and invasion through upregulating FOSL1

Cited by 18 publications

References 59 publications

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

MiR-33a targets FOSL1 and EN2 as a clinical prognostic marker for sarcopenia by glioma

The multifaceted functions of long non-coding RNA HOTAIR in neuropathologies and its potential as a prognostic marker and therapeutic biotarget

On the modulation of TRPM channels: Current perspectives and anticancer therapeutic implications

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