LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b

Gao, Yuan; Meng, Hao; Liu, Shupeng; Hu, Jingjing; Zhang, Yemin; Jiao, Tingting; Liu, Yujie; Ou, Jun; Wang, Dan; Yao, Lin; Liu, Shanrong; Ning, Hui

doi:10.1093/hmg/ddu502

Cited by 148 publications

(142 citation statements)

References 45 publications

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“…Furthermore, it is up-regulated in all four major subtypes of ovarian cancer compared to cultivated ovarian surface epithelial cells [44] . In addition, HOST2 has been reported to enhance tumor cell migration, invasion, and proliferation in epithelial ovarian cancer, possibly by the inhibition of miRNA let-7b tumor suppressor functions [21] .…”

Section: Human Ovarian Cancer-specific Transcript 2 (Host2)mentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Ovarian Cancer

Nikpayam

Tasharrofi

Sarrafzadeh

et al. 2017

IBJ

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Background: Ovarian cancer is the most fatal tumor of female's reproductive system, and several genetics and environmental factors are involved in its development. Various studies have already identified suitable biomarkers to facilitate the early detection, prognosis evaluation, and the assessment of treatment response. However, the aim of this review was to investigate the role of long non-coding RNAs (lncRNAs) in tumorigenesis process of ovarian cancer and their potential applications as ovarian cancer biomarkers. Methods: We performed an online literature search of the MEDLINE/PubMed databases using the key words ovarian cancer, lncRNA, and biomarker. Results: We found that several lncRNAs have been shown to be deregulated in ovarian cancer and the specific mechanism of their enrollment in ovarian cancer has been defined for a few of them. In addition, expression profiling has revealed an association between lncRNAs and patients' survival, metastasis potential as well as treatment response. Conclusions: Expression profiling as well as methylation analysis of lncRNAs in ovarian cancer may lead to the identification of novel biomarkers that can help in the classification of patients based on prognosis and treatment response.

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Section: Human Ovarian Cancer-specific Transcript 2 (Host2)mentioning

confidence: 99%

The Role of Long Non-Coding RNAs in Ovarian Cancer

Nikpayam

Tasharrofi

Sarrafzadeh

et al. 2017

IBJ

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“…These lncRNAs are involved in various biological processes of ovarian cancer, including chemotherapy, proliferation, apoptosis and metastasis (21)(22)(23)(24). Previous studies have suggested the potential role of lncRNAs in ovarian cancer to a certain extent (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), however, further investigation is required to explain their respective functions and mechanisms of action.…”

mentioning

confidence: 99%

Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin

Wang

Ren

et al. 2015

Oncology Letters

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Abstract. Previous studies have demonstrated that long non-coding RNAs (lncRNAs) serve an important role in carcinogenesis. BC200 is a lncRNA that is reportedly associated with ovarian cancer. The aim of the present study was to investigate this potential association between BC200 and ovarian cancer, and to subsequently analyze the biological function of BC200 in the disease. BC200 expression was compared in ovarian cancer tissue and normal ovarian tissue samples through the use of quantitative polymerase chain reaction. To allow the biological function of BC200 in ovarian cancer to be analyzed, small interfering RNA was used to knock down the expression of BC200 in SKOV3 and A2780 ovarian cancer cells. The proliferative, invasive and migratory abilities of the cells were identified by means of cell counting kits and Transwell assays. Carboplatin was also used to treat the ovarian cancer cells, and a luminescent cell viability assay was subsequently used to detect the sensitivity of the cells to the carboplatin. The results demonstrated that BC200 expression was reduced in ovarian cancer compared with normal ovarian tissue samples. In the SKOV3 and A2780 cells, BC200 exerted no effect on invasive or migratory ability, however, the inhibition of BC200 was demonstrated to promote cell proliferation. Additionally, it was observed that carboplatin induced BC200 expression in the cell lines, and that the inhibition of BC200 decreased the sensitivity of the cells to the drug. BC200 is therefore likely to have a tumor suppressive function in ovarian cancer by affecting cell proliferation. Furthermore, BC200 appears to serve a role in the mediation of carboplatin-induced ovarian cancer cell death.

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“…For example, Gao et al demonstrated that the lncRNA human ovarian cancer-specific transcript 2 promotes tumor cell migration, invasion and proliferation in epithelial ovarian cancer by modulating microRNA let-7b availability (21). lncRNA H19 expression was inhibited by histone H1.3, which contributes to the suppression of epithelial ovarian carcinogenesis (22).…”

Section: Discussionmentioning

confidence: 99%

Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

et al. 2017

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Abstract. Although numerous long non-coding RNAs (lncRNAs) have been identified to be important in human cancer, their potential regulatory roles in epithelial tumorigenesis and tumor progression in ovarian cancer remain unclear. The purpose of the present study was to investigate lncRNAs that were differentially expressed (DE) in epithelial ovarian cancer and to explore their potential functions. The lncRNA profiles in five pairs of human epithelial ovarian cancer tissues and their adjacent normal tissues were described using microarrays. The results of the microarray analysis revealed that 672 upregulated and 549 downregulated (fold-change ≥2.0) lncRNAs were DE between the cancerous and normal tissues. Reverse transcription-quantitative polymerase chain reaction was used to validate the microarray results using four upregulated (RP11-1C1.7, XLOC_003286, growth arrest-specific 5 and ZNF295-AS1) and four downregulated (protein tyrosine kinase 7, maternally expressed gene 3, AC079776.2 and ribosomal protein lateral stalk subunit P0 pseudogene 2) lncRNAs. Furthermore, gene ontology and pathway analyses were used to carry out functional analyses of the candidate genes of DE lncRNAs. The results identified lncRNAs with significantly altered expression profiles in human epithelial ovarian cancer cells compared with those in adjacent normal cells. These data offer new insights into the occurrence and development of epithelial ovarian cancer, and these lncRNAs may provide novel molecular biomarkers for further research on epithelial ovarian cancer.

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LncRNA-HOST2 regulates cell biological behaviors in epithelial ovarian cancer through a mechanism involving microRNA let-7b

Cited by 148 publications

References 45 publications

The Role of Long Non-Coding RNAs in Ovarian Cancer

The Role of Long Non-Coding RNAs in Ovarian Cancer

Downregulation of BC200 in ovarian cancer contributes to cancer cell proliferation and chemoresistance to carboplatin

Microarray expression profiling of long non-coding RNAs in epithelial ovarian cancer

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