LncRNA HEIH promotes cell proliferation, migration and invasion in cholangiocarcinoma by modulating miR-98-5p/HECTD4

Wan, Tao; Wang, Hongguang; Gou, Miaomiao; Si, Haiyan; Wang, Zhikuan; Yan, Huan; Liu, Tiee; Chen, Shiyun; Fan, Runjia; Qian, Niansong; Dai, Guanghai

doi:10.1016/j.biopha.2020.109916

Cited by 28 publications

(23 citation statements)

References 19 publications

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“…Our data suggest that HEIH in retinoblastoma serves as an oncogene, which was consistent with previous studies of HEIH in several types of human cancer. [14][15][16][17][18] Accumulating data demonstrated that lncRNA transcripts can act as endogenous decoys for miRNAs to influence cancer-related gene expression through their miRNA binding sites. For example, lncRNA H19 increased retinoblastoma cell viability, migration and invasion via miR-143/RUNX2 axis.…”

Section: Dovepressmentioning

confidence: 99%

“…13 Subsequently, researchers reported that HEIH was frequently up-regulated in various types of human cancer, including colorectal cancer, melanoma, esophageal squamous cell carcinoma, breast cancer and cholangiocarcinoma, and promoted cancer cell proliferation, migration and invasion through sponging tumor suppressor miRNAs. [14][15][16][17][18] Taken together, the above mentioned findings suggest that HEIH is a functional lncRNA in tumor progression, yet its biological role in retinoblastoma remains largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Gao¹,

Chu²,

Liu³

et al. 2020

OTT

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Background: Abnormally expressed long noncoding RNA (lncRNA) high expression in hepatocellular carcinoma (HEIH) has been implicated in many types of human cancer, and plays crucial roles in tumor development and progression. However, little is known about its function in retinoblastoma. Methods: qRT-PCR was used to determine the expression levels of HEIH, miR-194-5p and WEE1 in retinoblastoma tissues and cell lines. The trypan blue exclusion method, colony formation assay, wound-healing assay and transwell invasion assay were performed to evaluate the effects of HEIH, miR-194-5p and WEE1 on cell proliferation, migration and invasion. Bioinformatics analysis, dual-luciferase reporter assay and Western blot were employed to investigate the regulatory relationship among HEIH, miR-194-5p and WEE1. Results: We found that HEIH was up-regulated in retinoblastoma tissues and cell lines. Furthermore, high level of HEIH was associated with TNM stage, optic nerve invasion and choroidal invasion of patients with retinoblastoma. Functional studies showed that HEIH knockdown significantly suppressed retinoblastoma cell proliferation, migration and invasion. Mechanistically, HEIH promoted retinoblastoma progression by serving as a sponge of miR-194-5p to regulate WEE1 expression. Conclusion: Our work suggests that HEIH acts as an oncogenic lncRNA to promote retinoblastoma proliferation and metastasis, providing a new insight into the retinoblastoma treatment.

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Section: Dovepressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Gao¹,

Chu²,

Liu³

et al. 2020

OTT

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“…At the molecular level, HEIH sequesters miR‐98‐5p away from its target mRNA, including the HECT (homologous to the E6‐AP carboxyl terminus) domain E3 ubiquitin protein ligase 4. ( 60 ) LncRNA LINC01410 also promotes CCA cell proliferation and migration. LINC01410 is highly expressed in CCA tissues and cell lines.…”

Section: Lncrnas and Cancer‐associated Signaling Pathwaysmentioning

confidence: 98%

Long Noncoding RNAs in Cholangiocarcinoma

2021

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“…Studies from different groups have confirmed that the dysregulation of lncRNA expression is closely related to the biological behavior of CCA cells. Upregulation of these lncRNAs, including KCNQ1OT1 [48], LMCD1-AS1 [37], TP73-AS1 [22], SNHG1 [49], SOX2-OT [39], LINC01410 [50], ASAP1-IT1 [51], DANCR [52], FLVCR1-AS1 [53], NNT-AS1 [54], RMRP [55], CCAT2 [56], HOTAIR [57], LINC01296 [58], LOXL1-AS1 [59], NEAT1 [60], PVT1 [43], HEIH [61], LINC01061 [62], may promote the migration and invasion of CCA cells, . On the other hand, the downregulation of several lncRNAs plays the same role in CCA cells including LINC01714 [63], FENDRR [64], MEG3 [65], and MIR22HG [66].…”

Section: Promotion Of the Migration And Invasion Of Cca Cellsmentioning

confidence: 99%

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

Yang

Deng

et al. 2020

Cancer Communications

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Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numerous long noncoding RNAs (lncRNAs) have been identified as crucial players in the development of various cancers, including CCA. Abnormally expressed lncRNAs in CCA, regulated by some upstream molecules, significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms, including interactions with functional proteins, participation in competing for endogenous RNA (ceRNA) regulatory networks, activation of cancer‐related signaling pathways and epigenetic modification of gene expression. Furthermore, several lncRNAs are closely associated with the clinicopathological features of CCA patients, and are promising biomarkers for diagnosing and prognostication of CCA. Some of these lncRNAs play an important role in chemotherapy drug resistance. In addition, lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors, such as cholestatic liver diseases. In view of the difficulty of diagnosing CCA, more attention should be paid to detectable lncRNAs in the serum or bile. This review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of lncRNAs. Moreover, we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.

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LncRNA HEIH promotes cell proliferation, migration and invasion in cholangiocarcinoma by modulating miR-98-5p/HECTD4

Cited by 28 publications

References 19 publications

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

<p>Long Noncoding RNA HEIH Promotes Proliferation, Migration and Invasion of Retinoblastoma Cells Through miR-194-5p/WEE1 Axis</p>

Long Noncoding RNAs in Cholangiocarcinoma

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

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