LncRNA H19 aggravates primary graft dysfunction after lung transplantation via KLF5-mediated activation of CCL28

Li, Jiwei; Han, Zhijun; Zhu, Zibo; Zhang, Quan; Wei, Li

doi:10.1016/j.ajt.2023.06.015

Cited by 2 publications

(1 citation statement)

References 39 publications

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“…H19, a long-noncoding RNA, has been demonstrated to play a role in numerous pulmonary disease processes, and a 2023 study sought to examine a possible role in the development of PGD ( 135 ). They identified H19 within a signaling axis of PGD via transcriptome analysis, and when silenced in a murine model, found reduced inflammatory cell infiltration and secretion of CCL28, which itself stimulates inflammatory chemokine secretion, and decreased incidence of PGD ( 135 ). Identification of this signaling axis in PGD may allow for targeting of H19 and similar genomic pathways in the prevention of PGD.…”

Section: Methods Used To Mitigate Pgd and Its Effectsmentioning

confidence: 99%

Donor and recipient risk factors for the development of primary graft dysfunction following lung transplantation

Jenkins,

Verdiner,

Omar

et al. 2024

Front. Immunol.

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Primary Graft Dysfunction (PGD) is a major cause of both short-term and long-term morbidity and mortality following lung transplantation. Various donor, recipient, and technical risk factors have been previously identified as being associated with the development of PGD. Here, we present a comprehensive review of the current literature as it pertains to PGD following lung transplantation, as well as discussing current strategies to mitigate PGD and future directions. We will pay special attention to recent advances in lung transplantation such as ex-vivo lung perfusion, thoracoabdominal normothermic regional perfusion, and up-to-date literature published in the interim since the 2016 ISHLT consensus statement on PGD and the COVID-19 pandemic.

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Section: Methods Used To Mitigate Pgd and Its Effectsmentioning

confidence: 99%