lncRNA Gm16410 Mediates PM2.5-Induced Macrophage Activation via PI3K/AKT Pathway

Xu, Jingbin; Xu, Hong‐Tao; Ma, Kexin; Wang, Yue; Niu, Ben; Zhang, Li; Li, Fasheng

doi:10.3389/fcell.2021.618045

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…Wang et al (2020) corroborate the existence of an association between the PI3K/AKT pathway and the NLRP3 inflammasome in the context of lipopolysaccharide-induced lung injury [ 80 ]. Notably, recent findings reveal that exposure to particulate matter (PM 2.5) induces macrophage activation via the PI3K/AKT signaling pathway in murine lung tissue and RAW264.7 cells [ 81 ].…”

Section: The Signaling Mechanism Associated With Nlrp3-mediated Toxicitymentioning

confidence: 99%

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

Charles,

Prince

2024

Heliyon

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Section: The Signaling Mechanism Associated With Nlrp3-mediated Toxicitymentioning

confidence: 99%

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

Charles,

Prince

2024

Heliyon

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“…The mechanisms by which lncRNAs regulate M1 or M2 polarization in the pneumonia microenvironment are similar; for example, lncRNA p21 and lncRNA NKILA promote M2 polarization through NF-κB signaling pathway ( 54 , 64 ). Moreover, through the PI3K/AKT pathway, lncRNA Gm16410 reduces the expression of TNF-α in Mφs , inhibits inflammation, and stimulates polarization of Mφs induced by PM2.5, which participates in the activation of Mφs and process of inflammation ( 78 ). In addition, these effects have been described in numerous studies.…”

Section: Lncrnas Regulate Mφs Polarization In Inflammatory Diseasesmentioning

confidence: 99%

Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology

Jiang

2022

Front. Immunol.

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Precise expression and regulation of genes in the immune system is important for organisms to produce strong immunity towards pathogens and limit autoimmunity. In recent years, an increasing number of studies has shown that long noncoding RNAs (lncRNAs) are closely related to immune function and can participate in regulating immune responses by regulating immune cell differentiation, development, and function. As immune cells, the polarization response of macrophages (Mφs) plays an important role in immune function and inflammation. LncRNAs can regulate the phenotypic polarization of Mφs to M1 or M2 through various mechanisms; promote pro-inflammatory or anti-inflammatory effects; and participate in the pathogenesis of cancers, inflammatory diseases, infections, metabolic diseases, and autoimmune diseases. In addition, it is important to explore the regulatory mechanisms of lncRNAs on the dynamic transition between different Mφs phenotypes. Thus, the regulatory role of lncRNAs in the polarization of Mφs and their mechanism are discussed in this review.

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Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway

Huang

Duan

et al. 2023

Toxicology Research

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Background Epidemiological inquiry reveals that neuroinflammation and mitochondrial dysfunction caused by PM2.5 exposure are associated with Alzheimer’s disease. Nevertheless, the molecular mechanisms of mitochondrial dynamics and neuroinflammation induced by PM2.5 exposure remain elusive. In this study, our objective was to explore the impact of PM2.5 on mitochondrial dynamics and neuroinflammation, while also examining the reparative potential of scorpion venom heat-resistant synthetic peptide (SVHRSP). Methods Western blot and quantitative reverse transcription polymerase chain reaction (RT-qPCR) were employed to ascertain the protein and gene levels of IL-1β, IL-6, and TNF-α in BV2 cells. The concentration of IL-6 in the supernatant of the BV2 cell culture was measured by enzyme-linked immunosorbent assay. For the assessment of mitochondrial homeostasis, western blot, RT-qPCR, and cellular immunohistochemistry methods were utilized to investigate the protein and gene levels of DRP1 and MFN-2 in HT22 cells. In the context of signal pathway analyses, western blot, RT-qPCR, and immunofluorescence techniques were employed to detect the protein and gene expressions of PGC-1α and SIRT3 in HT22 cells, respectively. Following the transfection with siPGC-1αRNA, downstream proteins of PGC-1α/SIRT3 pathway in HT22 cells were investigated by Western blot and RT-qPCR. Results The experimental findings demonstrated that exposure to PM2.5 exacerbated neuroinflammation, resulting in elevated levels of IL-1β, IL-6, and TNF-α. Furthermore, it perturbed mitochondrial dynamics, as evidenced by increased DRP1 expression and decreased MFN-2 expression. Additionally, dysfunction was observed in the PGC-1α/SIRT3 signal pathway. However, intervention with SVHRSP ameliorated the cellular damage induced by PM2.5 exposure. Conclusions SVHRSP alleviated neuroinflammation and mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway.

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lncRNA Gm16410 Mediates PM2.5-Induced Macrophage Activation via PI3K/AKT Pathway

Cited by 3 publications

References 40 publications

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

Deciphering the molecular mechanism of NLRP3 in BPA-mediated toxicity: Implications for targeted therapies

Regulatory Mechanism of lncRNAs in M1/M2 Macrophages Polarization in the Diseases of Different Etiology

Scorpion venom heat-resistant peptide alleviates mitochondrial dynamics imbalance induced by PM2.5 exposure by downregulating the PGC-1α/SIRT3 signaling pathway

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