LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma

Ding, Gangqiang; Li, Wei; Liu, Junping; Zeng, Yanli; Mao, Chongshan; Yi, Kang; Shang, Jia

doi:10.1016/j.biopha.2017.07.046

Cited by 46 publications

(56 citation statements)

References 18 publications

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“…Former researches have confirmed the association between histone H3K27ac dysregulation and tumour progression 37. For example, lncRNA GHET1 is verified to be up‐regulated and activated by H3K27ac at promoter region 38. Herein, genome bioinformatics analysis in UCSC showed that H3K27ac was abundant at LINC00519 promoter region, suggesting that LINC00519 might be transcriptionally activated by histone acetylation in LUSC.…”

Section: Discussionmentioning

confidence: 89%

H3K27ac‐activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis

Rusidanmu

et al. 2020

Cell Proliferation

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Objectives Long non‐coding RNAs (lncRNAs) are extensively reported as participants in the biological process of diverse malignancies, including lung squamous cell carcinoma (LUSC). Long intergenic non‐protein coding RNA 519 (LINC00519) is identified as a novel lncRNA which has not yet been studied in cancers. Materials and Methods LINC00519 expression was detected by qRT‐PCR. The effect of LINC00519 on LUSC cellular activities was determined by in vitro and in vivo assays. Subcellular fractionation and FISH assays were conducted to identify the localization of LINC00519. The interaction between miR‐450b‐5p/miR‐515‐5p and LINC00519/YAP1 was verified by RIP, RNA pull‐down and luciferase reporter assays. Results Elevated level of LINC00519 was identified in LUSC tissues and cell lines. High LINC00519 level predicted unsatisfactory prognosis. Then, loss‐of‐function assays suggested the inhibitive role of silenced LINC00519 in cell proliferation, migration, invasion and tumour growth and promoting effect on cell apoptosis in LUSC. Mechanically, LINC00519 was activated by H3K27 acetylation (H3K27ac). Moreover, LINC00519 sponged miR‐450b‐5p and miR‐515‐5p to up‐regulate Yes1 associated transcriptional regulator (YAP1). Additionally, miR‐450b‐5p and miR‐515‐5p elicited anti‐carcinogenic effects in LUSC. Finally, rescue assays validated the effect of LINC00519‐miR‐450b‐5p‐miR‐515‐5p‐YAP1 axis in LUSC. Conclusions H3K27ac‐activated LINC00519 acts as a competing endogenous RNA (ceRNA) to promote LUSC progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis.

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Section: Discussionmentioning

confidence: 89%

H3K27ac‐activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis

Rusidanmu

et al. 2020

Cell Proliferation

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“…Multiple studies have also indicated that lncRNAs contribute to the carcinogenesis and progression of several tumors [6][7][8][9][10]. Recently, several studies have reported that lncRNA GHET1 might be related to prognosis in cancer patients [14][15][16][17][18][19][20][21][22][23][24]31]. Therefore, we performed this meta-analysis of 16 eligible studies to systematically evaluate the prognostic value of GHET1 in all cancers.…”

Section: Discussionmentioning

confidence: 99%

“…Clinically, several studies have indicated that up-regulation of GHET1 is associated with poor prognosis and advanced clinical features in several cancers [14][15][16][17][18][19][20][21][22][23][24]. Most existing studies suggest that GHET1 might be a potential biomarker for predicting the prognosis of human cancers.…”

Section: Introductionmentioning

confidence: 99%

“…Most existing studies suggest that GHET1 might be a potential biomarker for predicting the prognosis of human cancers. However, due to limitations such as small sample sizes and discrete outcomes, the findings of a single study may not accurately capture the phenomenon under examination [14][15][16][17][18][19][20][21][22][23][24]. Thus, we undertook a systematic review and meta-analysis of all eligible studies to perform an evidence-based evaluation of the prognostic role of GHET1 in cancer.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic value of long non-coding RNA GHET1 in cancers: a systematic review and meta-analysis

et al. 2020

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Background: A number of studies have demonstrated the critical role of long non-coding RNA gastric cancer high expressed transcript 1 (GHET1) in many cancers. This meta-analysis provides an evidence-based evaluation of the prognostic role of GHET1 in cancer. Materials and methods: Literature searches were conducted in several databases including Medline, Cochrane, EMBASE, CNKI, and Wanfang. The pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were used to evaluate the role of GHET1 in cancer. The study protocol was registered at PROSPERO (ID: CRD42018111252). Results: Sixteen studies, containing 1315 patients, were analyzed in this meta-analysis. The pooled results indicated that GHET1 overexpression was significantly associated with poor overall survival (OS) and disease-free survival (DFS) in cancer. Moreover, up-regulation of GHET1 expression predicted larger tumor size, positive lymph node metastasis, positive distant metastasis, and advanced TNM (tumor-node-metastases) stage in human cancers. Conclusion: There is a significant correlation between up-regulation of GHET1 and both poor prognosis and advanced clinicopathological cancer characteristics. GHET1 may be a potential prognostic predictor for human cancers.

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“…It has been confirmed to be an oncogene in a variety of cancers, including the hepatocellular carcinoma, gastric cancer and colorectal cancer. LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in the hepatocellular carcinoma . Knockdown of lncRNA GHET1 inhibits cell‐cycle progression and invasion .…”

Section: Introductionmentioning

confidence: 99%

Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers

Jiang

Zhang

Jin

et al. 2019

J Cellular Molecular Medi

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Recently, increasing studies have reported that long non‐coding RNA (lncRNA) gastric carcinoma highly expressed transcript 1 (GHET1) is highly expressed in variety of cancers and relevant to poor prognosis of cancer patients. Nevertheless, the results were inconsistent and the systematic analysis of lncRNA GHET1 in cancers has not been inspected. Thus, we aim to evaluate the relationship between lncRNA GHET1 expression and clinical outcomes in human cancers. We searched keywords in PubMed, Web of Science, Embase, Cochrane Library and ClinicalTrial.gov. Stata SE12.0 software was used in the quantitative meta‐analysis. Pooled hazard ratio (HR) and odds ratio with 95% confidence interval (95% Cl) were calculated to evaluate the clinical significance of lncRNA GHET1. Twelve studies totalling 761 patients with cancers were included for analysis. The pooled results of this study indicated that high lncRNA GHET1 expression level was significantly associated with poor overall survival (OS, HR = 2.30, 95% CI: 1.75‐3.02) in human cancers. The statistical significance was also detected in subgroup analysis stratified by analysis method, cancer type, sample size and follow‐up time respectively. In addition, the elevated lncRNA GHET1 expression was also significantly related to more advanced clinical stage, earlier lymph node metastasis, earlier distant metastasis and bigger tumour size. LncRNA GHET1 may serve as a promising biomarker for prognosis in Asians with cancers.

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LncRNA GHET1 activated by H3K27 acetylation promotes cell tumorigenesis through regulating ATF1 in hepatocellular carcinoma

Cited by 46 publications

References 18 publications

H3K27ac‐activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis

H3K27ac‐activated LINC00519 promotes lung squamous cell carcinoma progression by targeting miR‐450b‐5p/miR‐515‐5p/YAP1 axis

Prognostic value of long non-coding RNA GHET1 in cancers: a systematic review and meta-analysis

Overexpression of LncRNA GHET1 predicts an unfavourable survival and clinical parameters of patients in various cancers

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