[Retracted] lncRNA FGD5‐AS1 and miR‐130a Can Be Used for Prognosis Analysis of Patients with Chronic Periodontitis

Abstract

Background. lncRNA and microRNA affect the occurrence and development of many diseases, so they are expected to become diagnostic or predictive indicators. But the relationship between lncRNA FGD5-AS1 and miR-130a and the prognosis of chronic periodontitis is still unclear. The purpose of this study is to explore the prognostic value of the two in chronic periodontitis. Objective. This study set out to investigate the prognostic value of lncRNA FGD5-AS1 and miR-130a in chronic periodontitis. Methods. Eighty-seven patients with chronic periodontitis who visited our hospital from March 2016 to August 2017 were collected as an observation group (OG), and 72 subjects with periodontal health who underwent physical examination at the same time were collected as a control group (CG). The FGD5-AS1 and miR-130a expression levels of subjects in the two groups were compared, and prognosis of 87 patients who were reviewed one year later was counted. The expression levels of patients with different prognoses were compared when they were admitted to our hospital. We drew the ROC curve and explored the prognostic value of FGD5-AS1 and miR-130a. The risk factors for adverse prognosis were analyzed through logistic regression. Results. FGD5-AS1 was lowly expressed in patients, while miR-130a was highly expressed. FGD5-AS1 and miR-130a had certain diagnostic and predictive value in chronic periodontitis and patient prognosis. The higher the periodontal pocket, the higher the attachment loss. Lower FGD5-AS1 and higher miR-130a levels were independent prognostic risk factors. Conclusion. lncRNA FGD5-AS1 is lowly expressed in patients with chronic periodontitis, while miR-130a is highly expressed. Both of them have certain diagnostic and prognostic value in chronic periodontitis and may be potential diagnostic and prognostic indicators.

MicroRNA-28-5p as a potential diagnostic biomarker for chronic periodontitis and its role in cell proliferation and inflammatory response

“…GCF is derived from inflammatory exudate from the gingival microenvironment, which can pass through inflamed periodontal tissues, is easy to collect and non-invasive, and is used as an essential bio-mediator to identify and diagnose periodontal environments and related diseases. 20 And GCF miR-1226 4 and miR-130a 7 were recognized as diagnostic and prognostic markers of CP. In the present study, consistent with the findings of Fujimori et al.…”

“…In addition, due to high conservation, dysregulated miRNAs are often identified as diagnostic biomarkers. For example, miR-1226, 4 miR-143-3p, 6 and miR-130a 7 were identified as diagnostic biomarkers of CP. miR-28-5p, as one of the numerous miRNAs, has been reported to be involved in inflammatory responses in a variety of diseases.…”

Genome- and Transcriptome-Wide Association Studies Identify Susceptibility Genes and Pathways for Periodontitis

“…In 16q21, there were eight SNPs within the introns of lncRNA LINC02141 with p < 5 × 10 −8 . LncRNAs (e.g., AWPPH and FGD5-AS1) were reported to offer a strong foundation for periodontitis diagnosis and prognosis [38][39][40]. Unfortunately, LINC02141 was not detected by GSE10334 and GSE16134, making it difficult to study its expression level.…”

Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis

“…Currently, an increasing number of scholars are paying attention to the roles of noncoding RNAs (ncRNAs) (particularly lncRNAs and circRNAs) in the occurrence and development of diseases, including tumors ( Wang et al, 2019 ), periodontitis ( Yu and Chi 2021 ), and osteoarthritis ( Li et al, 2019 ). LncRNAs are RNA molecules with a length of more than 200 bases and lack protein-coding capacity ( Marchese et al, 2017 ).…”