LncRNA FAF attenuates hypoxia/ischaemia‐induced pyroptosis via the miR‐185‐5p/PAK2 axis in cardiomyocytes

Abstract

Coronary heart disease (CHD) remains a major cause of morbidity and mortality worldwide, which is responsible for nearly 1.8 million deaths in Europe, and similarly 1.7 million deaths in China annually. 1,2 Acute myocardial infarction (AMI), the worst outcome of CHD, accounts for many of these deaths. 3 Despite there has been a dramatic improvement in the overall mortality rate of AMI due to the advances in pharmacological therapy and reperfusion strategies over the past two decades, 4 quite a number of survivors eventually suffer from chronic heart failure, a long-term condition which leads to frequent hospitalizations, low quality of life and huge economic

Triptolide protects against podocyte injury in diabetic nephropathy by activating the Nrf2/HO-1 pathway and inhibiting the NLRP3 inflammasome pathway

“…The cell pyroptosis was examined by Hoechst 33342/propidium iodide (PI) double fluorescence staining kits (CA1120, Solarbio) [ 40 ]. After different treatments in groups, MPC5 cells at the logarithmic growth stage were cultured in 6-well plates and stained with 10 μL Hoechst 33342 solution at 37 °C for 10 min under dark conditions.…”