LncRNA ENST00000440246.1 Promotes Alzheimer’s Disease Progression by Targeting PP2A

Gao, Shang; Fan, Chang; Wang, Yongzhong; Yang, Wenming; Jiang, Hui

doi:10.1007/s10528-023-10552-0

Cited by 2 publications

(2 citation statements)

References 53 publications

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“…152 LncRNA ENST00000440246.1 enhances the progression of Alzheimer's Disease by targeting PP2A. 153 Consequently, different ncRNAs are warranted for detailed future investigation in addition to miRNAs.…”

Section: Discussionmentioning

confidence: 99%

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Chuang,

Yen,

Tang

et al. 2024

Environmental Toxicology

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Protein phosphatase 2A (PP2A), a heterotrimeric holoenzyme (scaffolding, catalytic, and regulatory subunits), regulates dephosphorylation for more than half of serine/threonine phosphosites and exhibits diverse cellular functions. Although several studies on natural products and miRNAs have emphasized their impacts on PP2A regulation, their connections lack systemic organization. Moreover, only part of the PP2A family has been investigated. This review focuses on the PP2A‐modulating effects of natural products and miRNAs' interactions with potential PP2A targets in cancer and non‐cancer cells. PP2A‐modulating natural products and miRNAs were retrieved through a literature search. Utilizing the miRDB database, potential PP2A targets of these PP2A‐modulating miRNAs for the whole set (17 members) of the PP2A family were retrieved. Finally, PP2A‐modulating natural products and miRNAs were linked via a literature search. This review provides systemic directions for assessing natural products and miRNAs relating to the PP2A‐modulating functions in cancer and disease treatments.

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Section: Discussionmentioning

confidence: 99%

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Chuang,

Yen,

Tang

et al. 2024

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…LncRNAs are master regulators of gene expression, functioning by regulating transcription, splicing, chromosome looping, chromatin modification, mRNA decay, as well as the regulation of miRNA in normal and disease states [25][26][27][28]. Levels of lncRNA detected in bodily fluids, such as blood, saliva and urine, are shown to be indicative of disease states and are suggested as biomarkers for cancer, bipolar disorder and COVID-19 [29][30][31][32][33][34]. The advantages of using lncRNA as biomarkers include their abundance and stability in body fluids, specificity to a disease, detectability using common molecular biology methods and reproducible quantitative results [35][36][37][38][39].…”

Section: Introductionmentioning

confidence: 99%

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

Patel,

Krause-Hauch,

Kenney

et al. 2024

IJMS

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More than 75% of traumatic brain injuries (TBIs) are mild (mTBI) and military service members often experience repeated combat-related mTBI. The chronic comorbidities concomitant with repetitive mTBI (rmTBI) include depression, post-traumatic stress disorder or neurological dysfunction. This study sought to determine a long noncoding RNA (lncRNA) expression signature in serum samples that correlated with rmTBI years after the incidences. Serum samples were obtained from Long-Term Impact of Military-Relevant Brain-Injury Consortium Chronic Effects of Neurotrauma Consortium (LIMBIC CENC) repository, from participants unexposed to TBI or who had rmTBI. Four lncRNAs were identified as consistently present in all samples, as detected via droplet digital PCR and packaged in exosomes enriched for CNS origin. The results, using qPCR, demonstrated that the lncRNA VLDLR-AS1 levels were significantly lower among individuals with rmTBI compared to those with no lifetime TBI. ROC analysis determined an AUC of 0.74 (95% CI: 0.6124 to 0.8741; p = 0.0012). The optimal cutoff for VLDLR-AS1 was ≤153.8 ng. A secondary analysis of clinical data from LIMBIC CENC was conducted to evaluate the psychological symptom burden, and the results show that lncRNAs VLDLR-AS1 and MALAT1 are correlated with symptoms of depression. In conclusion, lncRNA VLDLR-AS1 may serve as a blood biomarker for identifying chronic rmTBI and depression in patients.

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LncRNA ENST00000440246.1 Promotes Alzheimer’s Disease Progression by Targeting PP2A

Cited by 2 publications

References 53 publications

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Protein phosphatase 2A modulation and connection with miRNAs and natural products

Long Noncoding RNA VLDLR-AS1 Levels in Serum Correlate with Combat-Related Chronic Mild Traumatic Brain Injury and Depression Symptoms in US Veterans

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