LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway

Lei, Changjiang; Li, Shaoting; Fan, Ying; Li, Hua; Pan, Qingyun; Li, Yuan; Long, Zhixiong; Yang, Rui

doi:10.1080/15384047.2022.2132008

Cited by 17 publications

(5 citation statements)

References 34 publications

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“…Some pathways, such as mTOR and MYC pathways, were also found to be significantly upregulated in the high SGS group. These pathways have been reported to be associated with breast cancer malignancy [ 26 , 27 ]. At the single cell level, cell communication analysis also suggested that the signaling pathways such as WNT, VEGF, and TGF-β, which are widely known associated with tumor malignancy, were up-regulated in the high SGS group [ 17 – 19 ] NOTCH signaling has also been reported to be associated with the maintenance of stemness in breast cancer stem cells [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Lin,

Feng,

Liu

et al. 2023

Aging

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Breast cancer (BC) is a heterogeneous disease characterized by significant differences in prognosis and therapy response. Numerous prognostic tools have been developed for breast cancer. Usually these tools are based on bulk RNA-sequencing (RNA-Seq) and ignore tumor heterogeneity. Consequently, the goal of this study was to construct a single-cell level tool for predicting the prognosis of BC patients. In this study, we constructed a stemness-risk gene score (SGS) model based on single-sample gene set enrichment analysis (ssGSEA). Patients were divided into two groups based on the median SGS. Patients with a high SGS scores had a significantly worse prognosis than those with a low SGS, and these groups exhibited differences in several tumor characteristics, such as immune infiltration, gene mutations, and copy number variants. Our results indicate that the SGS is a reliable tool for predicting prognosis and response to immunotherapy in BC patients.

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Section: Discussionmentioning

confidence: 99%

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Lin,

Feng,

Liu

et al. 2023

Aging

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“…For instance, increased expression of lncRNA HCP5 has been identified by Guo et al to induce radiotherapy resistance in esophageal cancer tissues by promoting AKT activation through regulating miR-216a-3p/PDK1 axis [ 164 ]. Another well-documented lncRNA DUXAP8 increases radiotherapy resistance in breast cancer cells by activating the PI3K/AKT/mTOR signaling pathway [ 165 ]. Moreover, the expression of SNHG7 is demonstrated to be upregulated in TC tissues and correlated with [ 131 ]I resistance as the increased expression of SNHG7 promotes [ 131 ]I resistance in TC cells by sponging miR-9-5p and increasing DPP4 expression to activate PI3K/AKT [ 166 ].…”

Section: Ncrnas Effect Cancer Therapeutic Tolerance Through Metabolic...mentioning

confidence: 99%

The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming

Li,

Peng,

Tan

et al. 2024

Cancer Cell Int

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One of the key features of cancer is energy metabolic reprogramming which is tightly related to cancer proliferation, invasion, metastasis, and chemotherapy resistance. NcRNAs are a class of RNAs having no protein-coding potential and mainly include microRNAs, lncRNAs and circRNAs. Accumulated evidence has suggested that ncRNAs play an essential role in regulating cancer metabolic reprogramming, and the altered metabolic networks mediated by ncRNAs primarily drive carcinogenesis by regulating the expression of metabolic enzymes and transporter proteins. Importantly, accumulated research has revealed that dysregulated ncRNAs mediate metabolic reprogramming contributing to the generation of therapeutic tolerance. Elucidating the molecular mechanism of ncRNAs in cancer metabolic reprogramming can provide promising metabolism-related therapeutic targets for treatment as well as overcome therapeutic tolerance. In conclusion, this review updates the latest molecular mechanisms of ncRNAs related to cancer metabolic reprogramming.

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“…Lei et al. discovered that the lncRNA DUXAP8 is notably overexpressed in radioresistant breast cancer tissues, correlating with a worse prognosis ( 20 ). The study demonstrated that DUXAP8 overexpression contributes to increased radioresistance by activating the PI3K/AKT/mTOR pathway.…”

Section: Long Non-coding Rna and Micrornamentioning

confidence: 99%

Innovative therapeutic strategies to overcome radioresistance in breast cancer

Arnold,

Mangesius,

Portnaia

et al. 2024

Front. Oncol.

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Despite a comparatively favorable prognosis relative to other malignancies, breast cancer continues to significantly impact women’s health globally, partly due to its high incidence rate. A critical factor in treatment failure is radiation resistance – the capacity of tumor cells to withstand high doses of ionizing radiation. Advancements in understanding the cellular and molecular mechanisms underlying radioresistance, coupled with enhanced characterization of radioresistant cell clones, are paving the way for the development of novel treatment modalities that hold potential for future clinical application. In the context of combating radioresistance in breast cancer, potential targets of interest include long non-coding RNAs (lncRNAs), micro RNAs (miRNAs), and their associated signaling pathways, along with other signal transduction routes amenable to pharmacological intervention. Furthermore, technical, and methodological innovations, such as the integration of hyperthermia or nanoparticles with radiotherapy, have the potential to enhance treatment responses in patients with radioresistant breast cancer. This review endeavors to provide a comprehensive survey of the current scientific landscape, focusing on novel therapeutic advancements specifically addressing radioresistant breast cancer.

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LncRNA DUXAP8 induces breast cancer radioresistance by modulating the PI3K/AKT/mTOR pathway and the EZH2-E-cadherin/RHOB pathway

Cited by 17 publications

References 34 publications

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

Construction of stemness gene score by bulk and single-cell transcriptome to characterize the prognosis of breast cancer

The roles and molecular mechanisms of non-coding RNA in cancer metabolic reprogramming

Innovative therapeutic strategies to overcome radioresistance in breast cancer

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