LncRNA-CTS promotes metastasis and epithelial-to-mesenchymal transition through regulating miR-505/ZEB2 axis in cervical cancer

Feng, Shujun; Liu, Wei; Bai, Xiaoxu; Pan, Wenjing; Jia, Zhongzhi; Zhang, Shunjin; Zhu, Yu; Tan, Weihong

doi:10.1016/j.canlet.2019.09.002

Cited by 73 publications

(49 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…24,25 For instance, LncRNA-CTS accelerates growth and invasion of CC via regulating miR-505/ZEB2 signaling. 26 LncRNA GAS5-AS1 inhibits proliferation and migration of CC through stabilizing GAS5. 27 Linc00483 promotes CC growth and invasion via targeting miR-508-3p/RGS17 axis.…”

Section: Discussionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Liu

Wen

2020

CMAR

View full text Add to dashboard Cite

“…According to a previous report [ 25 ], miR-505 is poorly expressed in CC, which can inhibit the development of CC. The poor expression of miR-505 in CC was confirmed by RT-qPCR in our collected CC tissues ( Figure 1(a) ).…”

Section: Resultsmentioning

confidence: 99%

“…The abnormal expression of miRNAs is related to the pathological changes of humans, including cancer, and some are regarded as potential prognostic markers in different tumors, such as CC [ 29 ]. miR-505 was poorly expressed in CC and negatively correlated with tumor histology grade and lymph node metastasis [ 25 , 30 ]. Additionally, miR-940 inhibited CC cell proliferation, and USMB-miR-940 showed better effects [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Ultrasound Microbubble-Mediated microRNA-505 Regulates Cervical Cancer Cell Growth via AKT2

Zhang

et al. 2020

Analytical Cellular Pathology

View full text Add to dashboard Cite

The application of ultrasound and microbubbles (USMB-) mediated microRNA (miR) is a promising approach of gene delivery for cancer treatment. We aimed to discuss the effects of USMB-miR-505 on cervical cancer (CC) development. miR-505 mediated by USMB was prepared. The effect of miR-505 on its transfection efficiency and the effect of miR-505 on HeLa cell proliferation, cell cycle, apoptosis, migration, and invasion were studied. The target gene of miR-505 was predicted, and its expression in CC was detected. The effect of the target gene on HeLa cells was further verified. USMB-miR-505 showed a higher transfection efficiency than miR-505 alone. The inhibitory effect of miR-505 mediated by USMB on HeLa cells was better than miR-505. miR-505 targeted AKT2, which was upregulated in CC. Overexpression of AKT2 reversed the inhibitory effect of USMB-miR-505 on HeLa cell malignant behaviors. Overall, we highlighted that USMB-miR-505 inhibited HeLa cell malignant behaviors by targeting AKT2.

show abstract

“…21 Recently, the lncRNA-miRNA-mRNA axes have been verified in multiple cancers including CC. [22][23][24] In the study, we demonstrated that HPV16 E6 oncoprotein upregulated the expression of lncRNA GABPB1-AS1, and GABPB1-AS1 facilitated CC tumor and metastasis by sponging miR-519e-5p to activate Notch signaling.…”

Section: Introductionmentioning

confidence: 91%

HPV16 E6 oncoprotein‐induced upregulation of lncRNA GABPB1‐AS1 facilitates cervical cancer progression by regulating miR‐519e‐5p/Notch2 axis

et al. 2020

FASEB j.

View full text Add to dashboard Cite

Human papillomaviruses 16 (HPV16) is the primary causative agent of cervical cancer (CC). E6 oncoprotein plays a crucial role in cervical carcinogenesis and commonly cause the dysregulation of the long noncoding RNAs (lncRNAs) expression. However, the biological function of lncRNAs in HPV16‐related CC remains largely unexplored. In the present study HPV16 E6‐induced differential expression of lncRNAs, miRNA, and mRNA were identified using microarray‐based analysis and verified in tumor r cell lines and tumor tissues, and the function of lncRNA in CC was investigated in vitro and in vivo. We found that an lncRNA, named GABPB1‐AS1, was significantly upregulated in HPV16‐positive CC tissues and cell lines. GABPB1‐AS1 expression in HPV16‐positive CC tissues was positively associated with tumor size, lymph node metastasis, and FIGO stage. High expression of GABPB1‐AS1 was correlated with a poor prognosis for HPV16‐positive CC patients. Functionally, E6‐induced GABPB1‐AS1 overexpression facilitated CC cells proliferation and invasion in vitro and in vivo. Mechanistically, GABPB1‐AS1 acted as a competing endogenous RNA (ceRNA) by sponging miR‐519e‐5p, resulting in the de‐repression of its target gene Notch2 which is well known as an oncogene. Therefore, GABPB1‐AS1 functioned as a tumor activator in CC pathogenesis by binding to miR‐519e‐5p and destroying its tumor suppressive function. Collectively, current results demonstrate that GABPB1‐AS1 is associated with CC progression, and may be a promising biomarker or target for the clinical management of CC.

show abstract

LncRNA-CTS promotes metastasis and epithelial-to-mesenchymal transition through regulating miR-505/ZEB2 axis in cervical cancer

Cited by 73 publications

References 29 publications

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

<p>LINC01410 Knockdown Suppresses Cervical Cancer Growth and Invasion via Targeting miR-2467-3p/VOPP1 Axis</p>

Ultrasound Microbubble-Mediated microRNA-505 Regulates Cervical Cancer Cell Growth via AKT2

HPV16 E6 oncoprotein‐induced upregulation of lncRNA GABPB1‐AS1 facilitates cervical cancer progression by regulating miR‐519e‐5p/Notch2 axis

Contact Info

Product

Resources

About