lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter

Fan, ST; Tian, Tian; Lv, Xiaobin; Lei, Xinyuan; Yang, Zhaohui; Liu, Mo; Liang, Faya; Li, Shunrong; Lin, Xiaofeng; Lin, Zhaoyu; Xie, Shuhua; Li, Bowen; Chen, Weixiong; Pan, Guokai; Lin, Xinyu; Ou, Zhanpeng; Zhang, Yin; Peng, Yu; Xiao, Liping; Zhang, Lizao; Sun, Sheng; Zhang, Hanqing; Lin, Sigeng; Li, Qunxing; Zeng, Binghui; Kontos, Filippos; Ruan, Yi; Ferrone, Soldano; Lin, De–Chen; Tannous, Bakhos A.; Li, Jinsong

doi:10.1016/j.isci.2020.100835

Cited by 24 publications

(28 citation statements)

References 60 publications

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“…One possible explanation for association between high BRCA1 expression and poor prognosis, high BRCA1 would protect HCC from further DNA damage, which might promote resistance to chemotherapeutics. In tongue squamous cell carcinoma, lncRNA CISAL inhibited BRCA1 transcription by forming a tertiary structure at its promoter and associated favorable neoadjuvant chemosensitivity (Fan et al, 2020), which was consistent with our conjecture. Wang et al (2018) performed a systematic analysis to uncover the expression profiles and prognostic values of BRCA1 in digestive system cancers.…”

Section: Discussionsupporting

confidence: 91%

BRCA1 Is a Novel Prognostic Indicator and Associates with Immune Cell Infiltration in Hepatocellular Carcinoma

Mei

Wang

Xia

et al. 2020

DNA and Cell Biology

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The breast cancer gene 1 (BRCA1) is a tumor suppressor, and mutations or epigenetic inactivation will increase the risk of breast cancer oncogenesis. The current research aimed to explore the relationship between BRCA1 expression, prognosis, and tumor immunity in hepatocellular carcinoma (HCC). In this study, BRCA1 expression was analyzed via multiple online databases and its association with clinical characteristics, prognosis and genetic alterations was identified using the original The Cancer Genome Atlas-liver hepatocellular carcinoma cohorts. DNA methylation sites and their prognostic values were analyzed using MethSurv. The correlations between BRCA1 and immune infiltration were investigated via Tumor Immune Estimation Resource. As results, BRCA1 was significantly upregulated in tumor tissues in multiple HCC cohorts. Besides, high BRCA1 expression was correlated with race, advanced T stage, clinical stage, poor tumor grade, MSI status, and worse prognosis. Notably, BRCA1 expression was positively correlated with infiltration levels of B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells. The current findings imply that BRCA1 is associated with prognosis and immune infiltration, laying foundations for in-depth research on the role of BRCA1 in HCC.

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Section: Discussionsupporting

confidence: 91%

BRCA1 Is a Novel Prognostic Indicator and Associates with Immune Cell Infiltration in Hepatocellular Carcinoma

Mei

Wang

Xia

et al. 2020

DNA and Cell Biology

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“…(4) It was found that increased expression level of LINC01063 was significantly correlated with metastasis and poor prognosis of the patients with colon adenocarcinoma [ 31 ]. (5) Fan et al found that LINC01011 controlled cisplatin sensitivity and mitochondrial fission via suppressing BRCA1 transcription in a tongue SCC model [ 32 ]. (6) LINC02381 might have inhibiting effects on CRC tumorigenesis partly through regulating PI3K pathway [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma

Zhou

Zhang

et al. 2020

BioMed Research International

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There were no systematic researches about autophagy-related long noncoding RNA (lncRNA) signatures to predict the survival of patients with colon adenocarcinoma. It was necessary to set up corresponding autophagy-related lncRNA signatures. The expression profiles of lncRNAs which contained 480 colon adenocarcinoma samples were obtained from The Cancer Genome Atlas (TCGA) database. The coexpression network of lncRNAs and autophagy-related genes was utilized to select autophagy-related lncRNAs. The lncRNAs were further screened using univariate Cox regression. In addition, Lasso regression and multivariate Cox regression were used to develop an autophagy-related lncRNA signature. A risk score based on the signature was established, and Cox regression was used to test whether it was an independent prognostic factor. The functional enrichment of autophagy-related lncRNAs was visualized using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Ten prognostic autophagy-related lncRNAs (AC027307.2, AC068580.3, AL138756.1, CD27-AS1, EIF3J-DT, LINC01011, LINC01063, LINC02381, AC073896.3, and SNHG16) were identified to be significantly different, which made up an autophagy-related lncRNA signature. The signature divided patients with colon adenocarcinoma into the low-risk group and the high-risk group. A risk score based on the signature was a significantly independent factor for the patients with colon adenocarcinoma (HR=1.088, 95%CI=1.057−1.120; P<0.001). Additionally, the ten lncRNAs were significantly enriched in autophagy process, metabolism, and tumor classical pathways. In conclusion, the ten autophagy-related lncRNAs and their signature might be molecular biomarkers and therapeutic targets for the patients with colon adenocarcinoma.

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“…Given that current studies on lncRNA mechanisms converge on establishing intermolecular interactions with other molecules, such as proteins, DNA, and other RNAs, it is essential to elucidate the lncRNA-protein and lncRNA-DNA interactions they engage in. Recent studies [171,172] have reported that lncRNAs function by forming RNA-DNA triple helixes with DNAs. In tongue squamous cell carcinoma, lncRNA CISAL can be tethered to the gene promoter through RNA-DNA triple helix formation, spatially sequestering transcription factors away from DNA-binding sites and restraining transcription of tumor suppressor genes [171].…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Recent studies [171,172] have reported that lncRNAs function by forming RNA-DNA triple helixes with DNAs. In tongue squamous cell carcinoma, lncRNA CISAL can be tethered to the gene promoter through RNA-DNA triple helix formation, spatially sequestering transcription factors away from DNA-binding sites and restraining transcription of tumor suppressor genes [171]. LncRNA Fendrr can form RNA-DNA triple helixes in the promoter region of developmental genes and then serve as an anchor to recruit the histone-modifying protein PRC2 [172].…”

Section: Future Perspectivesmentioning

confidence: 99%

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

Yang

Deng

et al. 2020

Cancer Communications

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Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numerous long noncoding RNAs (lncRNAs) have been identified as crucial players in the development of various cancers, including CCA. Abnormally expressed lncRNAs in CCA, regulated by some upstream molecules, significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms, including interactions with functional proteins, participation in competing for endogenous RNA (ceRNA) regulatory networks, activation of cancer‐related signaling pathways and epigenetic modification of gene expression. Furthermore, several lncRNAs are closely associated with the clinicopathological features of CCA patients, and are promising biomarkers for diagnosing and prognostication of CCA. Some of these lncRNAs play an important role in chemotherapy drug resistance. In addition, lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors, such as cholestatic liver diseases. In view of the difficulty of diagnosing CCA, more attention should be paid to detectable lncRNAs in the serum or bile. This review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of lncRNAs. Moreover, we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.

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lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter

Cited by 24 publications

References 60 publications

BRCA1 Is a Novel Prognostic Indicator and Associates with Immune Cell Infiltration in Hepatocellular Carcinoma

BRCA1 Is a Novel Prognostic Indicator and Associates with Immune Cell Infiltration in Hepatocellular Carcinoma

Development of Prognostic Indicator Based on Autophagy-Related lncRNA Analysis in Colon Adenocarcinoma

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

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