LncRNA and Gene expression profiling of human bladder cancer

Abstract

Bladder cancer (BC) is the most common urologic neoplasms with a high rate of recurrence. The development of BC is a complex process, resulting from somke, drugs or bladder inflammation. However, the uinderlying mechanisms of BC tumorigenesis remained unclear. In this study, we performed RNA sequencing of three paired para-tumor and tumor tissuses from BC patients. Compared with para-tumor tissuses, BC tissues displayed 1136 upregulated and 1199 downregualted lncRNAs, and 1347 upregulated and 953 downregualted genes. Additionally, the common upregulated genes were mainly enriched in SNARE interactions, amino sugar and nucleotide sugar metabolism and antigen processing pathways. The common downregulated genes were mainly focused amino acid metabolism and drug meabolism signalings. More importantly, cytokine related genes were highly expressed in BC, which suggest that the dysregulation of immunoregulatory process and amino acid metabolism played a crucial role in the oncogenesis of BC.