LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating <i>SEPT2</i> Via Sponging miR-497-5p

Cai, Bo; Wang, Xichao; Bu, Qingao; Xue, Qingze; Zhang, Jun; Ding, Pengpeng; Sun, Da

doi:10.1089/cbr.2020.3688

Cited by 14 publications

(14 citation statements)

References 30 publications

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“…miR-497-5p has been recognized as a target of AFAP1-AS1 in breast cancer cells. Since this miRNA targets SEPT2, AFAP1-AS1 up-regulation results in up-regulation of SEPT2 ( 17 ). miR-145 is another target of AFAP1-AS1 in triple negative breast cancer cells (TNBC) MDA-MB-231 breast cancer cells.…”

Section: Cell Line Studiesmentioning

confidence: 99%

A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

et al. 2021

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AFAP1-AS1 is a long non-coding RNA which partakes in the pathoetiology of several cancers. The sense protein coding gene from this locus partakes in the regulation of cytophagy, cell motility, invasive characteristics of cells and metastatic ability. In addition to acting in concert with AFAP1, AFAP1-AS1 can sequester a number of cancer-related miRNAs, thus affecting activity of signaling pathways involved in cancer progression. Most of animal studies have confirmed that AFAP1-AS1 silencing can reduce tumor volume and invasive behavior of tumor cells in the xenograft models. Moreover, statistical analyses in the human subjects have shown strong correlation between expression levels of this lncRNA and clinical outcomes. In the present work, we review the impact of AFAP1-AS1 in the carcinogenesis.

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Section: Cell Line Studiesmentioning

confidence: 99%

A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

et al. 2021

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“…38,39 AFAP1-AS1 knocks down to inhibit the breast cancer cells progress through sponge-based miR-497-5P and lower SEPT2. 24 In mammalian cells, numerous studies have demonstrated the…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population

Yang,

Huang,

Sheng

et al. 2023

Cancer Reports

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BackgroundLong non encoding RNA (lncRNA) plays a crucial role in breast cancer. However, the prognostic role of AFAP1‐AS1 in breast cancer remains unclear.AimsTo investigate the relationship between the expression of long non‐coding RNA actin filament‐associated protein1 antisense RNA1 (AFAP1‐AS1) and prognosis of breast cancer.Methods and ResultsMeta‐analysis was performed to explore the correlation between AFAP1‐AS1 and breast cancer. The AFAP1‐AS1expression in patients with breast cancer tissue and adjacent normal tissue from 153 patients was determined by qRT‐PCR. Bioinformatics and Cox proportional‐hazards risk model were used to explore the relationship between expression of AFAP1‐AS1 and prognosis. The combined analysis revealed a significant correlation between AFAP1‐AS1 expression and both overall survival (hazard ratios, HR = 2.33, 95%Cl: 1.94–2.81, p < 0.001) as well as disease‐free survival/progression‐free survival (HR = 2.94, 95%CI: 2.35–3.67, p < 0.001). The relation between expression of AFAP1‐AS1 and breast cancer was determined in 153 breast cancer and adjacent normal tissues. The findings revealed a significantly higher AFAP1‐AS1expression levels in breast cancer tissues compared to adjacent normal tissues (p < 0.001). Additionally, patients exhibiting heightened levels of AFAP1‐AS1 expression were correlated with an unfavorable prognosis (HR = 2.35, 95%CI: 1.47–3.74, p < 0.001), which aligns consistently with the findings of the pooled analysis. The subgroup analysis of clinical characteristics revealed a significant association between high expression of AFAP1‐AS1 and TNM stage (HR = 1.72, 95%CI: 1.11–2.65, p = 0.015).ConclusionThis study demonstrated that AFAP1‐AS1 acts as an oncogene and may serve as a novel prognostic marker for breast cancer, particularly in the Chinese population.

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“…Furthermore, AFAP1-AS1 directly binds to miR-497-5p to upregulate the expression of Septin 2, a well-known oncogene. Depletion of AFAP1-AS1 inhibits proliferation and migration and induces apoptosis in breast cancer ( 71 ). In triple-negative breast cancer, AFAP1-AS1 sponges miR-154 to coordinate the expression of MutT homolog-1, which in turn induces cellular proliferation and invasion ( 72 ).…”

Section: Oncogenic Lncrnasmentioning

confidence: 99%

Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects

Wei

Zhang

et al. 2021

Front. Oncol.

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Breast cancer is the most common malignancy among women worldwide, excluding non-melanoma skin cancer. It is now well understood that breast cancer is a heterogeneous entity that exhibits distinctive histological and biological features, treatment responses and prognostic patterns. Therefore, the identification of novel ideal diagnostic and prognostic biomarkers is of utmost importance. Long non-coding RNAs (lncRNAs) are commonly defined as transcripts longer than 200 nucleotides that lack coding potential. Extensive research has shown that lncRNAs are involved in multiple human cancers, including breast cancer. LncRNAs with dysregulated expression can act as oncogenes or tumor-suppressor genes to regulate malignant transformation processes, such as proliferation, invasion, migration and drug resistance. Intriguingly, the expression profiles of lncRNAs tend to be highly cell-type-specific, tissue-specific, disease-specific or developmental stage-specific, which makes them suitable biomarkers for breast cancer diagnosis and prognosis.

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LncRNA AFAP1-AS1 Knockdown Represses Cell Proliferation, Migration, and Induced Apoptosis in Breast Cancer by Downregulating SEPT2 Via Sponging miR-497-5p

Cited by 14 publications

References 30 publications

A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

A Review on the Role of AFAP1-AS1 in the Pathoetiology of Cancer

Prognostic value of lncRNA AFAP1‐AS1 in breast cancer: a meta‐analysis and validated study in Chinese population

Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects

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