lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis

Xu, Cai; Shao, Yongfu; Xia, Tian; Yang, Yingzhen; Dai, Jihong; Lin, Li‐Rong; Zhang, Xinjun; Sun, Weiliang; Song, Haoming; Xiao, Bingxiu; Guo, Junming

doi:10.1007/s13277-014-2274-5

Cited by 84 publications

(78 citation statements)

References 21 publications

(24 reference statements)

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“…When using cell lines as models, we further found that GACAT2 was significantly downregulated in five gastric cancer cell lines (AGS, BGC-823, HGC-27, MGC-803, and SGC-7901) compared with normal gastric epithelial cell GES-1 [2]. Similar to the situations in cell lines, by expanding the gastric cancer sample size (313 samples), we found that GACAT2 was downregulated in 62.6 % gastric cancer tissues compared to the paired adjacent normal tissues [2]. It also significantly decreased in dysplasia compared with healthy control group.…”

mentioning

confidence: 89%

“…Shortly after the articles entitled "Low expression of lncRNAHMlincRNA717 in human gastric cancer and its clinical significances" and "lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis" published in Tumour Biology [1,2], the long noncoding RNA (lncRNA) HMlincRNA717 and AC130710 that were studied in these papers have been officially named by HUGO Gene Nomenclature Committee (HGNC). Human Gene Nomenclature Database (www.genenames.org/hgncsearches) shows that their HGNC ID is 50516 and 50847, respectively.…”

mentioning

confidence: 99%

“…It also significantly decreased in dysplasia compared with healthy control group. Its expression level was significantly associated with cancer distant metastasis, perineural invasion, and venous invasion [2]. AC130710's previous symbol/ name is "long intergenic nonprotein coding RNA 1458," LINC01458.…”

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confidence: 99%

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Long noncoding RNA HMlincRNA717 and AC130710 have been officially named as gastric cancer associated transcript 2 (GACAT2) and GACAT3, respectively

Chen

Xiao

et al. 2014

Tumor Biol.

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confidence: 89%

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confidence: 99%

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Long noncoding RNA HMlincRNA717 and AC130710 have been officially named as gastric cancer associated transcript 2 (GACAT2) and GACAT3, respectively

Chen

Xiao

et al. 2014

Tumor Biol.

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“…A great number of miRNAs have been identified to be expressed at low levels in tumors, acting as oncogenes, antioncogene, or regulators of cancer stem cells and metastasis [19]. Reduced expression of miR-129 has been found in multiple tumor cell lines and in primary tumors, including GC [7,14,20]. yu and co-workers [7] suggested that all miR-129 family members (miR-129-1-3p, miR-129-2-3p, and miR-129-5p) showed growth inhibitory in GC by regulating cell proliferation.…”

Section: Discussionmentioning

confidence: 99%

“…Based on previous reports [7,8,14], we investigated the expression pattern of miR-129-5p in GC tissues and peripheral blood samples. In addition, the effect of miR-129-5p on GC cell proliferation, migration, and invasion were explored by altering the endogenous levels of miR-129-5p in human GC cell line SGC-7901 cells.…”

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confidence: 99%

MiR-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8

Jiang¹,

Wang²,

Li³

et al. 2016

neo

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Expression of microRNA-129-5p (miR-129-5p) has been reported to decrease in gastric cancer (GC). However, little information is available about how miR-129-5p affects cell migration and invasion of GC. Cancer samples and matched non-tumor adjacent tissues were obtained from patients with GC. Besides, peripheral blood samples were collected from both the patients and healthy volunteers. Expression of miR-129-5p was analyzed by real-time PCR (RT-PCR). After transfection with miR-129-5p mimics, miR-129-5p inhibitor, or negative controls in human GC cell line SGC-7901, cell viability, colony-formation ability, migration, and invasion assay were evaluated. Luciferase reporter assay, RT-PCR, and enzyme-linked immunosorbent assay (ELISA) were performed to explore whether interleukin-8 was a target of miR-129-5p. Further, small interfering RNA (siRNA) against IL-8 was transfected into cells, and then the effects of miR-129-5p inhibitor on migration and invasion were assessed. MiR-129-5p was down-regulated in both GC samples and blood samples compared to their matched non-tumor adjacent tissues and healthy volunteers (both P < 0.05). Compared to the control group, transfection with miR-129-5p inhibitor markedly increased the cell viability, colony-forming ability, and numbers of migrated and invaded cells. Luciferase reporter assay confirmed that IL-8 was a direct target of miR-129-5p, and IL-8 was negatively regulated by miR-129-5p. Cotransfection of miR-129-5p inhibitor with si-IL-8 reversed the effect of miR-129-5p inhibitor on the migration and invasion of the cells. MiR-129-5p and regulates migration and invasion of GC cells by targeting IL-8.

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Retracted: microRNA‐129‐5p involved in the neuroprotective effect of dexmedetomidine on hypoxic‐ischemic brain injury by targeting COL3A1 through the Wnt/β‐catenin signaling pathway in neonatal rats

Zhou

Liu

Wang

et al. 2018

J of Cellular Biochemistry

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Our study aims to elucidate the mechanisms how microRNA-129-5p (miR-129-5p) involved in neuroprotective effect of dexmedetomidine (DEX) on hypoxic-ischemic brain injury (HIBI) by targeting COL3A1 through the Wnt/β-catenin signaling pathway in neonatal rats. A total of 120 rats were obtained, among which 15 rats were selected as sham group and rest rats as model, DEX, DEX + negative control (DEX + NC), DEX + miR-129-5p mimics, DEX + miR-129-5p inhibitors, DEX + XAV-939 and DEX + miR-129-5p inhibitors + XAV-939 groups. Dual-luciferase reporter assay was performed for the target relationship between miR-129-5p and COL3A1. Weight rate and water content of cerebral hemisphere were detected. qRT-PCR and Western blotting were conducted to detect miR-129-5p expression and expressions of COL3A1, E-cadherin, T-cell factor (TCF)-4, and β-catenin. The DEX, DEX + miR-129-5p mimics, DEX + XAV-939 groups had increased weight rate of cerebral hemisphere, but decreased water content of left cerebral hemisphere, levels of COL3A1, β-catenin, TCF-4, and E-cadherin in hippocampus compared with the model and DEX + miR-129-5p inhibitors groups. COL3A1 was verified as the target gene of the miR-129-5p. Compared with the DEX + NC and DEX + miR-129-5p inhibitors + XAV-939 groups, the DEX + XAV-939 and DEX + miR-129-5p mimics groups had elevated weight rate of cerebral hemisphere, but reduced water content of left cerebral hemisphere, levels of COL3A1, β-catenin, TCF-4, and E-cadherin in hippocampus. Our findings demonstrate that miR-129-5p improves the neuroprotective role of DEX in HIBI by targeting COL3A1 through the Wnt/β-catenin signaling pathway in neonatal rats. This article is protected by copyright. All rights reserved.

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lncRNA-AC130710 targeting by miR-129-5p is upregulated in gastric cancer and associates with poor prognosis

Cited by 84 publications

References 21 publications

Long noncoding RNA HMlincRNA717 and AC130710 have been officially named as gastric cancer associated transcript 2 (GACAT2) and GACAT3, respectively

Long noncoding RNA HMlincRNA717 and AC130710 have been officially named as gastric cancer associated transcript 2 (GACAT2) and GACAT3, respectively

MiR-129-5p is down-regulated and involved in migration and invasion of gastric cancer cells by targeting interleukin-8

Retracted: microRNA‐129‐5p involved in the neuroprotective effect of dexmedetomidine on hypoxic‐ischemic brain injury by targeting COL3A1 through the Wnt/β‐catenin signaling pathway in neonatal rats

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