LncRNA AC020978 facilitates non–small cell lung cancer progression by interacting with malate dehydrogenase 2 and activating the AKT pathway

Abstract

Lung cancer is the most common cancer, accounting for approximately 1.6 million deaths or 28% of all deaths from cancer globally each year. 1 Clinical research has shown that 81% of patients with clinically detected lung cancer live for less than 5 years. In addition, most cases are diagnosed at a distant stage because of the typically asymptomatic nature of the early stages of the disease. 2

Silencing lncRNA‐DARS‐AS1 suppresses nonsmall cell lung cancer progression by stimulating miR‐302a‐3p to inhibit ACAT1 expression

“…Both the PI3K/AKT and ERK signaling pathways are classical signaling pathways involved in tumorigenesis, 51,52 and numerous studies have confirmed that AKT/ERK promotes NSCLC progression. 53,54 On one hand, our team had proved that ERK pathway can be activated by ACAT1 in prostate cancer to regulate tumor cells proliferation, migration, and invasion.…”

ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association

“…Increasing evidence has indicated that Long non-coding RNAs (lncRNAs) [ 5 ] regulate cancer metastasis-related signaling pathways via interacting with microRNA, mRNA and proteins, such as HOTAIR [ 6 ], AC020978 [ 7 ] and TMEM220-AS1 [ 8 ]. This highlights the dual nature of lncRNAs with both tumor suppressor and oncogene functions in cancers.…”

ELFN1-AS1 Promotes GDF15-Mediated Immune Escape of Colorectal Cancer from NK cells by Facilitating GCN5 and SND1 Association

“…Increasing evidence has indicated that long non-coding RNAs (lncRNAs) [5] regulate cancer metastasisrelated signaling pathways via interacting with microRNA, mRNA and proteins, such as HOTAIR [6], AC020978 [7] and TMEM220-AS1 [8]. This highlights the dual nature of lncRNAs with both tumor suppressor and oncogene functions in cancers.…”