LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway

Duan, Weili; Kong, Xue; Li, Juan; Li, Peilong; Zhao, Yinghui; Liu, Tong; Binang, Helen Barong; Wang, Yunshan; Li, Du; Wang, Chuanxin

doi:10.3389/fcell.2020.565355

Cited by 21 publications

(17 citation statements)

References 46 publications

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“…Most of the lncRNAs included in GILncSig were found to be associated with multiple cancers other than GC. The lncRNA, AC010789.1, was reported to promote the progression of colorectal cancer by targeting the microRNA-432-3p/ZEB1 axis and activating the Wnt/β-catenin signaling pathway (25). It has been reported that HOX-lncRNAs have the capacity to influence the carcinogenesis of lung cancer (26).…”

Section: Discussionmentioning

confidence: 99%

Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer

Sun¹,

Jiang

Chen³

et al. 2021

Ann Transl Med

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Background: Characterized by multiple features, genomic stability-related markers, such as microsatellite instability (MSI), were regulated as an important predictor of chemotherapy and immunity responses in cancer treatment. The aim of our study was to identify a genomic instability-associated long non-coding RNA (lncRNA) signature to help predict the survival and therapy response of gastric cancers (GCs).Methods: We used RNA sequencing and single nucleotide variant (SNV) data from The Cancer Genome Atlas-stomach adenocarcinoma (TCGA-STAD) datasets to explore genomic instability-associated lncRNAs.Hierarchical cluster analyses of 197 differentially expressed genomic instability-associated lncRNAs were performed to separate GC patients into two groups, namely, the genomically unstable (GU)-like group and the genomically stable (GS)-like group.Results: Cox regression analysis was conducted to finally identify six lncRNAs (LINC02678, HOXA10-AS, RHOXF1-AS1, AC010789.1, LINC01150, and TGFB2-AS1) with independent prognostic value to establish the genomic instability-associated lncRNA signature (GILncSig). Based on the SNV analysis, GILncSig was correlated with accumulation of gene mutation counts. Further comparisons between different risk score groups were performed to assess chemotherapy drug sensitivity and immune landscape variations. Conclusions:Our study not only revealed the genomic instability-associated lncRNAs in GCs, but provided a key method and resource for further studies of the role of these lncRNAs play, and introduced a potential new way to identify genomic instability-associated cancer biomarkers.

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Section: Discussionmentioning

confidence: 99%

Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer

Sun¹,

Jiang

Chen³

et al. 2021

Ann Transl Med

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“…Selectively binding miRNAs by lncRNAs contributes to inhibiting their transcription and promoting their degradation and induces EMT of cRc cells (63,72,90). In addition, those lncRNAs also promote the expression of nuclear β-catenin, cyclin d1, c-Myc, N-cadherin, vimentin, cd44, Jun and TcF1 via activating transcription factor and targeting miRNA, such as the lncRNA-ARAP1-AS1/YY1 (63) and lncRNA-Ac010789.1/miR-432-3p/ZEB1 axes (90). circRNAs exhibit specific roles as the sponges of miRNAs (74).…”

Section: Abnormality Of Non-coding Rnas (Ncrnas)mentioning

confidence: 99%

“…LncRNAsact as competing endogenous RNAs (ceRNAs) to be involved inWnt/β-catenin signaling via sponging miRNAs ( 65 , 96 ), for example, lncRNA-PART1 sponging miR-150-5p/miR-520h ( 86 ) and lncRNA-NEAT1 sponging miR-486-5p ( 89 ). Selectively binding miRNAs by lncRNAs contributes to inhibiting their transcription and promoting their degradation and induces EMT of CRC cells ( 63 , 72 , 90 ). In addition, those lncRNAs also promote the expression of nuclear β-catenin, cyclin D1, c-Myc, N-cadherin, vimentin, CD44, Jun and TCF1 via activating transcription factor and targeting miRNA, such as the lncRNA-ARAP1-AS1/YY1 ( 63 ) and lncRNA-AC010789.1/miR-432-3p/ZEB1 axes ( 90 ).…”

Section: Role Of Wnt/β-catenin Signaling In Colorectal Cancer (Crc)mentioning

confidence: 99%

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)

Sun

et al. 2021

Int J Mol Med

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colorectal cancer (cRc) is one of the most common carcinomas. Although great progress has been made in recent years, cRc survival remains unsatisfactory due to high metastasis and recurrence. Understanding the underlying molecular mechanisms of cRc tumorigenesis and metastasis has become increasingly important. Recently, aberrant Wnt/β-catenin signaling has been reported to be strongly associated with cRc tumorigenesis, metastasis and recurrence. Therefore, the Wnt/β-catenin signaling pathway has potential value as a therapeutic target for cRc. In the present review, the dysregulation of this pathway in cRc and the promoting or suppressing function of therapeutic targets on cRc were explored. In addition, the interaction between this pathway and epithelial-mesenchymal transition (EMT), cell stemness, mutations, metastasis-related genes and tumor angiogenesis in cRc cells were also investigated. Numerous studies on this pathway may help identify the potential diagnostic and prognostic markers and therapeutic targets for cRc. Contents1. Introduction 2. Role of Wnt/β-catenin signaling in colorectal cancer (cRc) 3. Therapeutic strategies targeting Wnt/β-catenin signaling for cRc 4. challenges in targeting Wnt/β-catenin signaling in cRc 5. conclusions and future perspectives

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“…LncRNA AK002107 inversely controls miR-140-5p and triggers EMT in OC by targeting TGFBR1 (Tang et al, 2019 ). LncRNA AC010789.1 promotes colorectal cancer progression by targeting the microRNA-432-3p/ZEB1 axis and the Wnt/β-catenin signaling pathway (Duan et al, 2020 ). A study of the BRCA1/2 ceRNA network in OC patients with wild-type BRCA1/2 revealed a novel three-lncRNA signature that could predict both prognosis and chemo-response (Zhang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Long Non-coding RNA LINC01969 Promotes Ovarian Cancer by Regulating the miR-144-5p/LARP1 Axis as a Competing Endogenous RNA

Chen

Yang

et al. 2021

Front. Cell Dev. Biol.

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Accumulating evidence has shown that long non-coding RNAs (lncRNAs) can be used as biological markers and treatment targets in cancer and play various roles in cancer-related biological processes. However, the lncRNA expression profiles and their roles and action mechanisms in ovarian cancer (OC) are largely unknown. Here, we assessed the lncRNA expression profiles in OC tissues from The Cancer Genome Atlas (TCGA) database, and one upregulated lncRNA, LINC01969, was selected for further study. LINC01969 expression levels in 41 patients were verified using quantitative real-time polymerase chain reaction (qRT-PCR). The in vitro effects of LINC01969 on OC cell migration, invasion, and proliferation were determined by the CCK-8, ethynyl-2-deoxyuridine (EdU), wound healing, and Transwell assays. Epithelial–mesenchymal transition (EMT) was evaluated using qRT-PCR and Western blotting. The molecular mechanisms of LINC01969 in OC were assessed through bioinformatics analysis, RNA-binding protein immunoprecipitation (RIP), dual luciferase reporter gene assays, and a rescue experiment. Finally, in vivo experiments were conducted to evaluate the functions of LINC01969. The results of the current study showed that LINC01969 was dramatically upregulated in OC, and patients with lower LINC01969 expression levels tended to have better overall survival. Further experiments demonstrated that LINC01969 promoted the migration, invasion, and proliferation of OC cells in vitro and sped up tumor growth in vivo. Additionally, LINC01969, which primarily exists in the cytoplasm, boosted LARP1 expression by sponging miR-144-5p and promoted the malignant phenotypes of OC cells. In conclusion, the LINC01969/miR-144-5p/LARP1 axis is a newly identified regulatory signaling pathway involved in OC progression.

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LncRNA AC010789.1 Promotes Colorectal Cancer Progression by Targeting MicroRNA-432-3p/ZEB1 Axis and the Wnt/β-Catenin Signaling Pathway

Cited by 21 publications

References 46 publications

Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer

Genomic instability-associated lncRNA signature predicts prognosis and distinct immune landscape in gastric cancer

Therapeutic strategies targeting Wnt/β‑catenin signaling for colorectal cancer (Review)

Long Non-coding RNA LINC01969 Promotes Ovarian Cancer by Regulating the miR-144-5p/LARP1 Axis as a Competing Endogenous RNA

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