LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection

Gao, Yuan; Yang, Yazheng; Wei, Jianmei; Yue, Jianmei; Wang, Ya; Zhang, Qianjing; Jin, Mengli; Wang, Rong; Yang, Xiaorong; Zhang, Junqi; Liu, Xinqi; Liu, Lin; Zhang, Yuan; Yang, Rongcun

doi:10.1038/s41423-023-00995-1

Cited by 4 publications

(1 citation statement)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NEAT1 , a lncRNA, emerges as a biomarker for S. typhimurium infection, and is significantly upregulated during infection, serving as a differential marker from other Salmonella strains or heat-inactivated S. typhimurium [ 65 ]. Another lncRNA, LNCGM1082 , induced by S. typhimurium in macrophages serves as a molecular scaffold, mediating the binding of protein kinase Cδ with the inflammasome NLRC4 to induce the phosphorylation and activation of NLRC4, thereby promoting the host immune defense against infection [ 66 ]. The T cell-derived enhancer-like lncRNA termed NeST (also known as IFNG-AS1 ) can alter the host susceptibility to S. typhimurium by regulating the epigenetic marking of IFNγ-encoding chromatin, affecting the expression of related genes.…”

Section: Lncrnas In Bacterial Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

View full text Add to dashboard Cite

Zoonoses are diseases and infections naturally transmitted between humans and vertebrate animals. They form the dominant group of diseases among emerging infectious diseases and represent critical threats to global health security. This dilemma is largely attributed to our insufficient knowledge of the pathogenesis regarding zoonotic spillover. Long non-coding RNAs (lncRNAs) are transcripts with limited coding capacity. Recent technological advancements have enabled the identification of numerous lncRNAs in humans, animals, and even pathogens. An increasing body of literature suggests that lncRNAs function as key regulators in zoonotic infection. They regulate immune-related epigenetic, transcriptional, and post-transcriptional events across a broad range of organisms. In this review, we discuss the recent research progress on the roles of lncRNAs in zoonoses. We address the classification and regulatory mechanisms of lncRNAs in the interaction between host and zoonotic pathogens. Additionally, we explore the surprising function of pathogen-derived lncRNAs in mediating the pathogenicity and life cycle of zoonotic bacteria, viruses, and parasites. Understanding how these lncRNAs influence the zoonotic pathogenesis will provide important therapeutic insights to the prevention and control of zoonoses.

show abstract

Section: Lncrnas In Bacterial Zoonosesmentioning

confidence: 99%

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Xu,

He,

Yang

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase- 4/11 by LPS through lncRNA57RIK

Gao

Yue

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Gut microbiota contributes to the regulation of host immune response and homeostasis. Bile acid (BA) derivatives from gut microbiota can affect the differentiation and function of the immune cells. However, it is incompletely clear for the regulation of BA metabolites in these immune cells. Here we investigated the effects the BA metabolites on the macrophages. Results: We here find that BA metabolites can regulate sensitivity of macrophages to LPS and or Gram-negative bacteria. BA derivatives could induce lncRNA57RIKexpression through sphingosine-1-phosphate receptor 2 (S1PR2) in the macrophages of mice and humans, which play a critical role in Gram-negative bacteria mediated IL-1βmaturation and pyroptosis of macrophages. This lncRNA57RIK could bind intracellular proteases caspase-4/11 with guanylate-binding protein 1 (GBP1) in the human and mice together to cause LPS mediated activation of caspase-4/11. Murine or human lncRNA57RIK knockout (KO) macrophages did not produce response(s) to LPS or Gram-negative bacteria. LncRNA57RIK KO mice had also reduced inflammatory responses to LPS or Salmonella typhimurium (S.T) infection. Conclusion: Taken together, gut microbiota derived BA metabolites mediated lncRNA57RIK is necessary for LPS induced caspase-4/11 activation.

show abstract

Systematic Analysis of Long Non-Coding RNAs in Inflammasome Activation in Monocytes/Macrophages

Qian,

Distefano,

Ilieva

et al. 2023

ncRNA

View full text Add to dashboard Cite

The NLRP3 inflammasome plays a pivotal role in regulating inflammation and immune responses. Its activation can lead to an inflammatory response and pyroptotic cell death. This is beneficial in the case of infections, but excessive activation can lead to chronic inflammation and tissue damage. Moreover, while most of the mammalian genome is transcribed as RNAs, only a small fraction codes for proteins. Among non-protein-coding RNAs, long non-coding RNAs (lncRNAs) have been shown to play key roles in regulating gene expression and cellular processes. They interact with DNA, RNAs, and proteins, and their dysregulation can provide insights into disease mechanisms, including NLRP3 inflammasome activation. Here, we systematically analyzed previously published RNA sequencing (RNA-seq) data of NLRP3 inflammasome activation in monocytes/macrophages to uncover inflammasome-regulated lncRNA genes. To uncover the functional importance of inflammasome-regulated lncRNA genes, one inflammasome-regulated lncRNA, ENSG00000273124, was knocked down in an in vitro model of macrophage polarization. The results indicate that silencing of ENSG00000273124 resulted in the up-regulation tumor necrosis factor (TNF), suggesting that this lncRNA might be involved in pro-inflammatory response in macrophages. To make our analyzed data more accessible, we developed the web database InflammasomeDB.

show abstract

LNCGM1082-mediated NLRC4 activation drives resistance to bacterial infection

Cited by 4 publications

References 57 publications

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Unveiling the Hidden Regulators: The Impact of lncRNAs on Zoonoses

Bile acid derivatives from gut microbiota promote GBPs-mediated activation of caspase- 4/11 by LPS through lncRNA57RIK

Systematic Analysis of Long Non-Coding RNAs in Inflammasome Activation in Monocytes/Macrophages

Contact Info

Product

Resources

About