Lnc-ZEB2-19 Inhibits the Progression and Lenvatinib Resistance of Hepatocellular Carcinoma by Attenuating the NF-κB Signaling Pathway through the TRA2A/RSPH14 Axis

Cao, Mingbo; Ren, Yupeng; Li, Yuxuan; Deng, Junfeng; Su, Xiaorui; Tang, Yongchang; Feng, Yong; Deng, Hongkui; Yang, Gaoyuan; He, Zhiwei; Liu, Bo; Deng, Meihai; Yao, Zhicheng

doi:10.7150/ijbs.85270

Cited by 3 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…During cancer development, uncontrolled proliferation and insensitivity to cell death are often accompanied by the activation of NF-κB signaling [ 33 ], this is reflected in a variety of cancers, including breast cancer [ 34 ], prostate cancer [ 35 ], esophageal squamous cell carcinoma [ 36 ], lymphoma [ 37 ], lung adenocarcinoma [ 38 ], etc. Abnormal NF-κB signaling also frequently leads to abnormal changes in tumor resistance, local inflammatory response, and immune microenvironment [ 38 – 41 ].…”

Section: Discussionmentioning

confidence: 99%

Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications

Sun,

Chen,

2023

Aging

View full text Add to dashboard Cite

Kidney renal clear cell carcinoma (KIRC), a common malignant tumor of the urinary system, is the most aggressive renal tumor subtype. Since the discovery of nuclear factor kappa B (NF-κB) in 1986, many studies have demonstrated abnormal NF-κB signaling is associated with the development of various cancers, including kidney renal clear cell carcinoma. In this study, the relationship between NF-κB and kidney renal clear cell carcinoma was confirmed using bioinformatics analysis. First, we explored the differential expression of copy number variation (CNV), single nucleotide variant (SNV), and messenger RNA (mRNA) in NF-κB-related genes in different types of cancer, as well as the impact on cancer prognosis and sensitivity to common chemotherapy drugs. Then, we divided the mRNA expression levels of NF-κB-related genes in KIRC patients into three groups through GSVA cluster analysis and explored the correlation between the NF-κB pathway and clinical data of KIRC patients, classical cancer-related genes, common anticancer drug responsiveness, and immune cell infiltration. Finally, 11 tumor-related genes were screened using least absolute shrinkage and selection operator (LASSO) regression to construct a prognostic model. In addition, we used the UALCAN and HPA databases to verify the protein levels of three key NF-κB-related genes ( CHUK, IKGGB, and IKBKG ) in KIRC. In conclusion, our study established a prognostic survival model based on NF-κB-related genes, which can be used to predict the prognosis of patients with KIRC.

show abstract

Section: Discussionmentioning

confidence: 99%

Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications

Sun,

Chen,

2023

Aging

View full text Add to dashboard Cite

show abstract

Upregulation of LncRNA-LHX2 Promotes Hepatocellular Carcinoma Proliferation, Migration, Invasion and Metastasis via Targeting VEGFA by Sequestering of MiR-939-5p

Fang,

Lin,

Gan

et al. 2024

j biomed nanotechnol

View full text Add to dashboard Cite

Due to the challenges in early diagnosis and lack of specific biomarkers, liver cancer remains one of the most prevalent and lethal tumor types. Numerous studies have shown that long noncoding RNA (lncRNA) plays a crucial role in the regulation of various malignant tumors, including liver cancer. Here, we discussed the function and effect of LncRNA-LHX2 in the tumorigenesis and progression of liver cancer, which was significantly upregulated in liver cancer tissues, compared to the benign liver tissues. To improve the accuracy and efficiency of tests like qRT-PCR, we employed nano-magnetic beads for nucleic acid extraction from tissues and cells. In our experiments using HepG2 cells, silencing of LncRNA-LHX2 effectively suppressed cell proliferation, migration, and invasion by interacting with miR-939-5p, which targets VEGFA. Interestingly, overexpression of miR-939-5p also impaired malignant functions of HepG2 cells. However, simultaneously inhibition of miR-939-5p expression can partially restored the inhibitory effect on HepG2 cells resulting from LncRNA-LHX2 knockdown. Consistently, our in vivo results from tumor mice model also suggested that knockout of LncRNA-LHX2 inhibited the tumor growth and suppressed epithelial mesenchymal transition (EMT) process, while silencing of miR-939-5p exhibited the opposite effect. However, when both LncRNA-LHX2 and miR-939-5p were simultaneously interfered with, the tumor growth was partially alleviated. Based on these results, our study highlights the malignant impact of LncRNA-LHX2 in the progression of liver cancer, indicating its potential as a candidate biomarker for liver cancer diagnosis.

show abstract

GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1‑autophagy axis

Wu,

Fan,

Liu

et al. 2024

Exp Ther Med

View full text Add to dashboard Cite

Lnc-ZEB2-19 Inhibits the Progression and Lenvatinib Resistance of Hepatocellular Carcinoma by Attenuating the NF-κB Signaling Pathway through the TRA2A/RSPH14 Axis

Cited by 3 publications

References 38 publications

Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications

Role of NF-κB pathway in kidney renal clear cell carcinoma and its potential therapeutic implications

Upregulation of LncRNA-LHX2 Promotes Hepatocellular Carcinoma Proliferation, Migration, Invasion and Metastasis via Targeting VEGFA by Sequestering of MiR-939-5p

GDF11 inhibits the malignant progression of hepatocellular carcinoma via regulation of the mTORC1‑autophagy axis

Contact Info

Product

Resources

About