Lnc<scp>RNA NR</scp>2F1‐<scp>AS</scp>1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting <scp>ABCC</scp>1 via miR‐363

Huang, Hai; Chen, Jie; Ding, Chengming; Jin, Xin; Jia, Zeming; Peng, Jian

doi:10.1111/jcmm.13605

Cited by 132 publications

(88 citation statements)

References 27 publications

(45 reference statements)

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“…MAGI2‐AS3 is another confirmed lncRNA that can suppress hepatocellular carcinoma cell proliferation and migration by acting as an endogenous sponge of miR‐374b‐5p . NR2F1‐AS1 can regulate hepatocellular carcinoma oxaliplatin resistance through targeting miR‐363‐ABCC1 pathway . In our analysis, MAGI2‐AS3 and NR2F1‐AS1 showed highly positive correlation with COL1A1 via miR‐143‐3p.…”

Section: Discussionmentioning

confidence: 53%

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

et al. 2020

Cancer Medicine

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Long noncoding RNAs (lncRNAs) have important biological functions as competing endogenous RNAs (ceRNAs) in tumors, yet the functions and regulatory mechanisms of lncRNA‐related ceRNAs in gastric cancer have not been fully elucidated. In this study, we constructed a lncRNA‐miRNA‐mRNA ceRNA network and identified potential lncRNA biomarkers in gastric cancer. Basing on the RNA profiles downloaded from The Cancer Genome Atlas (TCGA) platform, the gastric cancer‐specific differentially expressed lncRNAs, miRNAs, and mRNAs were screened for constructing a ceRNA network using bioinformatic tools. The enrichment analysis of the biological processes in Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes pathways was performed on the ceRNA‐related DEmRNAs. According to the modularization of protein‐protein interaction (PPI) network, we extracted a ceRNA subnetwork and analyzed the correlation between the expression of the lncRNAs involved and specific clinical features of patients. Next, the expression of highly up‐regulated in liver cancer (HULC) and RP11‐314B1.2 showed significant changes in several pathological processes involved in gastric cancer, and nine lncRNAs were found to be correlated with the overall survival of patients with gastric cancer. Through the univariate and multivariate Cox regression analyses, two lncRNAs (LINC00106 and RP11‐999E24.3) were identified and utilized to establish a risk score model for assessing the prognosis of patients. The analysis results were also partially verified using quantitative real‐time PCR. The findings from this study indicate that HULC, RP11‐314B1.2, LINC00106, and RP11‐999E24.3 could be considered as potential therapeutic targets or prognostic biomarkers in gastric cancer, and provide a new perspective for cancer pathogenesis research.

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Section: Discussionmentioning

confidence: 53%

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

et al. 2020

Cancer Medicine

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“…In general, HCC tumours are genetically and phenotypically very heterogeneous as they arise from a background of different chronic pathological conditions such as liver cirrhosis and fibrosis that are most frequently associated with hepatitis B or hepatitis C virus infections, alcoholic liver diseases or metabolic disorders . Although there are various treatment strategies available, including conventional chemotherapy, surgical resection, liver transplantation and radiotherapy, the cure rate of HCC patients is very low . Besides the lack of highly reliable biomarkers to detect early‐stage tumours and the presence of primary liver diseases that limit the application of chemotherapeutics, the major reasons for poor patient outcome and high mortality rates associated with HCC are resistance to conventional anticancer therapy, a high frequency of recurrences and the formation of metastases …”

Section: Introductionmentioning

confidence: 99%

“…Although there are various treatment strategies available, including conventional chemotherapy, surgical resection, liver transplantation and radiotherapy, the cure rate of HCC patients is very low . Besides the lack of highly reliable biomarkers to detect early‐stage tumours and the presence of primary liver diseases that limit the application of chemotherapeutics, the major reasons for poor patient outcome and high mortality rates associated with HCC are resistance to conventional anticancer therapy, a high frequency of recurrences and the formation of metastases …”

Section: Introductionmentioning

confidence: 99%

“…chemotherapeutics, the major reasons for poor patient outcome and high mortality rates associated with HCC are resistance to conventional anticancer therapy, a high frequency of recurrences and the formation of metastases. 1,4,[8][9][10][11] As for other types of cancers also HCC tumours are thought to arise from so called cancer stem cells (CSCs) that represent a small sub-population of tumour cells with stem cell-like characteristics.…”

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confidence: 99%

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Generation and characterization of hepatocellular carcinoma cell lines with enhanced cancer stem cell potential

Muenzner

Kunze

Lindner

et al. 2018

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC) is one of the most common causes for cancer‐related death worldwide with rapidly increasing incidence and mortality rates. As for other types of cancers, also in HCC cancer stem cells (CSCs) are thought to be responsible for tumour initiation, progression and therapy failure. However, as rare subpopulations of tumour tissue, CSCs are difficult to isolate, thus making the development of suitable and reliable model systems necessary. In our study, we generated HepG2 subclones with enriched CSC potential by application of the spheroid formation method and subsequent single‐cell cloning. Analyses in several 2D and 3D cell culture systems as well as a panel of functional assays both in vitro and in vivo revealed that the generated subclones displayed characteristic and sustained features of tumour initiating cells as well as highly aggressive properties related to tumour progression and metastasis. These characteristics could clearly be correlated with the expression of CSC markers that might have prognostic value in the clinical HCC setting. Therefore, we conclude that our CSC enriched HepG2 clones certainly represent suitable model systems to study the role of CSCs during HCC initiation, progression and drug resistance.

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“…Here we observe that upregulation of this gene is related to downregulation of miR-363 in this cell line, that is the first such observation. However, downregulation of miR-363 was associated with ABCC1 overexpression in oxoplatin hepatocellular carcinoma cell lines [87].…”

Section: Discussionmentioning

confidence: 91%

The significance of microRNA genes expression in ovarian cancer cell lines resistant to cytotoxic drugs

Kaźmierczak¹,

Jopek²,

Sterzyńska³

et al. 2019

Preprint

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Ovarian cancer is the most fatal type of gynecological cancer. The main reason for high mortality is the development of drug resistance. It can be related to increased expression of drug transporters and increased expression of extracellular matrix (ECM) proteins. miRNA is a short noncoding RNA that regulates expression of about 60% of genes in the human genome and plays a crucial role in developing cancer, including resistance to chemotherapy.Our foremost aim was to exhibit alterations in the miRNA expression levels in the cisplatin (CIS), paclitaxel (PAC), doxorubicin (DOX), and topotecan (TOP) -resistant variants of W1 sensitive ovarian cancer cell line using miRNA microarray. The second goal was to identify miRNAs responsible for the regulation of drug-resistant genes.According to our observation, alterations in the expression of 40 miRNA genes. The level of expression of 21 genes was upregulated in at least one drug-resistant cell line. The expression of 19 genes was downregulated in at least one drug-resistant cell line. We identified target genes for 22 miRNAs. Target analysis showed that miRNA regulates key genes responsible for drug resistance. Among others, we observed regulation of the ABCB1 (MDR1) gene in the W1PR1 cell line by miR-363 and regulation of the COL3A1 gene in the W1TR cell line by miR-29a.Hence, on the basis of our findings, results indicate that genes responsible for drug resistance development in ovarian cancer can be regulated by miRNA.

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LncRNA NR2F1‐AS1 regulates hepatocellular carcinoma oxaliplatin resistance by targeting ABCC1 via miR‐363

Cited by 132 publications

References 27 publications

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

Integrated analysis of a ceRNA network reveals potential prognostic lncRNAs in gastric cancer

Generation and characterization of hepatocellular carcinoma cell lines with enhanced cancer stem cell potential

The significance of microRNA genes expression in ovarian cancer cell lines resistant to cytotoxic drugs

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