LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China

Cao, Bangwei; Tian, Xiuyun; Li, Yong; Jiang, Pingwei; Ning, Tao; Xing, Haiping; Zhao, Yiqiang; Zhang, Chunfeng; Shi, Xianliang; Chen, Dafang; Shen, Yan; Ke, Yang

doi:10.1093/carcin/bgi071

Cited by 75 publications

(87 citation statements)

References 32 publications

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“…Furthermore, eight studies were excluded because of the limited number. In total, we included 26 eligible studies in the meta-analysis (Cao et al, 2005;Yang et al, 2005;Dai et al, 2007;He et al, 2007;Shuyama et al, 2007;Zhou et al, 2007;Chen et al, 2008;Li et al, 2008;Liu et al, 2008;Lu et al, 2008;Zhao et al, 2009;Liu et al, 2010;Koshiol et al, 2010;Wang et al, 2010;Ayshamgul et al, 2011;Han et al, 2011;Zhang et al, 2011;Guo et al, 2012;Hu et al, 2012;Qu et al, 2012;Liu et al, 2013;Zhang et al, 2013;Cui et al, 2014;Liu et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

Zhang

Guo²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Section: Resultsmentioning

confidence: 99%

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

Zhang

Guo²,

Chen³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Several studies have reported an association between the genetic variants of Arg to His substitution at codon 60 of Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study LMP2 (LMP2-60) and Gln to Lys substitution at codon 145 of LMP7 (LMP7-145) and the risk of numerous malignant diseases, including ovarian cancer, colon cancer and esophageal carcinoma (13)(14)(15). However, the association between LMP2 and LMP7 polymorphisms and the risk of GC has not been investigated to date.…”

Section: Introductionmentioning

confidence: 99%

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

Yang

Tang

et al. 2015

Oncol Lett

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Abstract. The integrality of low molecular weight protein (LMP)2/LMP7 function plays an important role in the processing of GC cell antigens. The purpose of the present hospital-based case-control study was to estimate the effect of polymorphisms in the LMP2 and LMP7 genes on the risk of GC. Polymerase chain reaction-restriction fragment length polymorphism analysis was used to distinguish the Arg to His substitution at codon 60 of LMP2 (LMP2-60) and the Gln to Lys substitution at codon 145 of LMP7 (LMP7-145) in 502 gastric cancer patients and 502 age and gender-matched cancer-free control individuals. The Lys allele of the LMP7-145 variant was more frequent in GC patients compared with control individuals [P=0.004; adjusted odds ratio (OR), 1.39; 95% confidence interval (CI), 1.11-1.74]. The Gln/Lys and Lys/Lys genotypes increased the risk of GC compared with the Gln/Gln genotype (P=0.049 and P=0.041, respectively; adjusted OR, 1.32 and 2.13, respectively; 95% CI, 1.00-1.73 and 1.03-4.39, respectively). Compared with the Gln/Gln genotype, the LMP7-145 Gln/Lys and Lys/Lys variants of the LMP7 gene were also associated with increased susceptibility to GC (P=0.017; adjusted OR, 1.38; 95% CI, 1.06-1.80). Haplotype analysis revealed that the LMP2 (Arg)-LMP7 (Lys) haplotype was associated with increased risk of GC (P=0.013, adjusted OR=1.34, 95% CI=1.06-1.70). Stratified analysis revealed that the association between the risk of GC and the variant genotypes of LMP7-145 was stronger in older individuals (>59 years), males and non-smokers. However, no association between the LMP2-60 polymorphism and the risk of GC was observed. The present results suggest that the LMP7-145 genetic variant contributes to increased susceptibility to GC, and the Lys allele is an independent risk factor for GC.

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“…Polymorphisms of TAP genes have been associated with various diseases such as tuberculosis (Wang et al, 2012), ankylosing spondylitis (Feng et al, 2009), leprosy (Shinde et al, 2013), idiopathic bronchiectasis (Dogru et al, 2007), cystic fibrosis (Ozbas-Gerceker et al, 2002) and also with the risk of occurence of several malignant tumors including colon cancer (Yang et al, 2005), cervical carcinoma (Mehta et al, 2007) and esophageal carcinoma (Cao et al, 2005). To the best of our knowledge there has been no study on the association of TAP gene polymorphisms with hematological malignancies.…”

Section: Association Of Tap1 and Tap2 Gene Polymorphisms With Hematolmentioning

confidence: 99%

“…TAP gene polymorphisms were found to be associated with colon cancer (Yang et al, 2005), cervical carcinoma (Mehta et al, 2007) and esophageal carcinoma (Cao et al, 2005). However, literature rewieving yielded no specific study on the role of TAP polymorphisms in the pathogenesis of hematological malignancies.…”

mentioning

confidence: 99%

Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies

Özbas‐Gerçeker

Bozman²,

Gezici³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Transporter associated with antigen presenting (TAP) 1 and TAP2 genes are localized in the major histocompatability complex (MHC) class II region and form a heterodimer playing a key role in endogenous pathways for antigen presentation. Defects of these genes have been reported to be common in different types of cancer. Polymorphisms identified in these loci have also been investigated and reported to be associated with several autoimmune disorders, viral infections and neoplasms. In the present study, for the first time, the allele and genotype frequencies of TAP1-333, TAP2-565, TAP2-651 and TAP2-665 were determined in patients with hematological malignancies (HM) using a PCR-RFLP method and compared with the frequencies in the control group. Our results suggested an association of TAP1-333 polymorphism with multiple myeloma-MM and TAP2-565 polymorphism with chronic lymphoid leukemia-CLL. In addition, it could be concluded that the TAP2-665 GG genotype might be a risk factor for all types of hematological malignancies included in this study.

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LMP7/TAP2 gene polymorphisms and HPV infection in esophageal carcinoma patients from a high incidence area in China

Cited by 75 publications

References 32 publications

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

Prevalence of Human Papillomavirus 16 in Esophageal Cancer Among the Chinese Population: a Systematic Review and Meta-analysis

Association between LMP2 and LMP7 gene polymorphisms and the risk of gastric cancer: A case-control study

Association of TAP1 and TAP2 Gene Polymorphisms with Hematological Malignancies

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