LMO2 promotes the development of AML through interaction with transcription co-regulator LDB1
Lihui Lu,
Jianwei Wang,
Fang Fang
et al.
Abstract:One of the characteristics of leukemia is that it contains multiple rearrangements of signal transduction genes and overexpression of non-mutant genes, such as transcription factors. As an important regulator of hematopoietic stem cell development and erythropoiesis, LMO2 is considered an effective carcinogenic driver in T cell lines and a marker of poor prognosis in patients with AML with normal karyotype. LDB1 is a key factor in the transformation of thymocytes into T-ALL induced by LMO2, and enhances the st… Show more
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