LMO1 polymorphisms and the risk of neuroblastoma: Assessment of meta‐analysis of case‐control studies

Abstract

Neuroblastoma (NB), a neuroendocrine tumour, is one of the most prevalent cancers in children. The link between LMO1 polymorphisms and NB has been investigated by several groups, rendering inconclusive results. Here, with this comprehensive systematic review and up‐to‐date meta‐analysis, we aim to distinctively elucidate the possible correlation between LMO1 polymorphisms and NB susceptibility. Eligible studies were systematically researched and identified using PubMed, Web of Science and Scopus databases up to 10 February 2019. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the strength of the associations. Our findings revealed that rs110419 and rs2168101 polymorphisms were significantly associated with a decreased risk of NB in all genetic models. In addition, the rs4758051 variant appeared protective against NB in homozygous, dominant and allele genetic models, whereas the rs10840002 variant markedly decreased the risk of NB in the allele model. In contrast, the rs204938 polymorphism showed a positive association with NB susceptibility in allele genetic models. In summary, our meta‐analysis is the first to provide clear evidence of an association between specific polymorphisms of LMO1 and susceptibility to NB. Of note, additional larger well‐designed studies would be helpful to further evaluate and confirm this association.

LIM domain only 1: an oncogenic transcription cofactor contributing to the tumorigenesis of multiple cancer types

“…Interestingly, other studies involving rs204938 did not observe this association in either the Chinese or African American populations [60,62–65] . A recent meta-analysis performed by Hashemi et al [68] in 2020 confirmed most of the results on LMO1 SNPs from previous studies. They reported that the LMO1 polymorphisms rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs2168101 G>T, and rs204938 C>T were associated with decreased susceptibility to neuroblastoma.…”

LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study

“…This discovery was opposite to a meta-analysis publication that assessed the association between LMO1 gene polymorphism and neuroblastoma risk. In that meta-analysis, the researcher found that the rs2168101 TT polymorphism was more likely to reduce the risk of neuroblastoma than the rs2168101 GT/GG polymorphisms, with an OR of 0.48 in the recessive model (TT vs. GT + GG: OR = 0.48, 95% CI = 0.31–0.75, P = 0.001) [ 41 ]. The obvious differences were mainly attributed to the following reasons: the relatively small size of subject populations, selection bias for participants, chance of the experiments, etc.…”

Somatic Copy Number Alterations and Mutation Landscape in Before and Post-treatment Malignant Rhabdoid Tumor

“…LMO1 functions as a neuroblastoma oncogene and is implicated as an oncogene in colorectal and lung cancer. 37,38 Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of the extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling. Additionally, they are involved in disease processes such as arthritis and metastasis and have been reported as biomarkers of various cancers.…”