Untitled

Reynolds, Peggy; Cone, James E.; Layefsky, Michael; Goldberg, Debbie; Hurley, Susan

doi:10.1023/a:1015284014563

Cited by 99 publications

(34 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The NHANES sample included unemployed persons too, a group less likely to be healthy [21]. Other cohort studies of female flight attendants did find higher than expected incidence of both breast cancer and melanoma [17] in California, Iceland and Sweden, although the elevated risk of breast cancer in Swedish crew was not significant and was not associated with length of employment [13,16]. Further, two separate meta-analyses of published incidence studies also found elevated risk for breast cancer and melanoma [11,18].…”

Section: Discussionmentioning

confidence: 99%

The self-reported health of U.S. flight attendants compared to the general population

et al. 2014

View full text Add to dashboard Cite

BackgroundFew studies have examined the broad health effects of occupational exposures in flight attendants apart from disease-specific morbidity and mortality studies. We describe the health status of flight attendants and compare it to the U.S. population. In addition, we explore whether the prevalence of major health conditions in flight attendants is associated with length of exposure to the aircraft environment using job tenure as a proxy.MethodsWe surveyed flight attendants from two domestic U.S. airlines in 2007 and compared the prevalence of their health conditions to contemporaneous cohorts in the National Health and Nutrition Survey (NHANES), 2005-2006 and 2007-2008. We weighted the prevalence of flight attendant conditions to match the age distribution in the NHANES and compared the two populations stratified by gender using the Standardized Prevalence Ratio (SPR). For leading health conditions in flight attendants, we analyzed the association between job tenure and health outcomes in logistic regression models.ResultsCompared to the NHANES population (n =5,713), flight attendants (n = 4,011) had about a 3-fold increase in the age-adjusted prevalence of chronic bronchitis despite considerably lower levels of smoking. In addition, the prevalence of cardiac disease in female flight attendants was 3.5 times greater than the general population while their prevalence of hypertension and being overweight was significantly lower. Flight attendants reported 2 to 5.7 times more sleep disorders, depression, and fatigue, than the general population. Female flight attendants reported 34% more reproductive cancers. Health conditions that increased with longer job tenure as a flight attendant were chronic bronchitis, heart disease in females, skin cancer, hearing loss, depression and anxiety, even after adjusting for age, gender, body mass index (BMI), education, and smoking.ConclusionsThis study found higher rates of specific diseases in flight attendants than the general population. Longer tenure appears to explain some of the higher disease prevalence. Conclusions are limited by the cross-sectional design and recall bias. Further study is needed to determine the source of risk and to elucidate specific exposure-disease relationships over time.

show abstract

Section: Discussionmentioning

confidence: 99%

The self-reported health of U.S. flight attendants compared to the general population

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Earlier studies showed a significant increase in breast cancer incidence among female flight attendants in several countries [2-6,9,10]. Some studies attribute this increase, at least partially, to occupational risk factors, e.g.…”

Section: Discussionmentioning

confidence: 99%

“…The question whether female cabin crew have a higher risk of breast cancer than other women has been the subject of several studies in recent years. A significant increase of breast cancer incidence among female flight attendants has been found in several countries, as shown by studies from Finland, Denmark, Iceland and the USA [2-6]. A smaller, non-significant increase was found by two studies from Norway and Sweden [7,8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of risk factors for breast cancer in German airline cabin crew: a cross-sectional study

Winter

Blettner

Zeeb

2014

J Occup Med Toxicol

View full text Add to dashboard Cite

BackgroundMany epidemiological studies point to an increased risk of breast cancer among female airline cabin crew. Possible causes include occupational factors (e.g. cosmic radiation exposure, chronodisruption), as well as lifestyle and reproductive factors.AimsTo investigate the frequency of various risk factors in German flight attendants which are recognised to be associated with breast cancer.Methods2708 current and former female cabin crew were randomly selected by a flight attendants’ union and mailed a questionnaire; 1311 responded (48% response). Descriptive statistics were used to compare the distribution of breast cancer risk factors with general German population data.ResultsOn average, cabin crew were 3.0 cm (95% CI 2.7-3.3) taller than the comparison group, while their body mass index was 2.5 kg/m2 (95% CI 2.4-2.6) lower. We found less use of hormone replacement therapy, but longer average use of oral contraceptives. Nulliparity among respondents aged 45+ was 57% (95% CI 54%-60%) compared to 16%. Average age at first birth was 32.1 years (95% CI 31.7-32.4) vs. 25.5 years. The birth rate was 0.62 (95% CI 0.58-0.67), less than half the population average of 1.34. Alcohol consumption was considerably higher, whereas cabin crew tended to smoke less and performed more physical exercise.ConclusionWe found important differences in terms of anthropometric, gynaecological, reproductive and lifestyle factors. Some of these differences (e.g. higher nulliparity, alcohol consumption, taller size) could contribute to a higher breast cancer risk, whereas others could lead to a reduction (e.g. increased physical exercise, lower BMI, less HRT use).

show abstract

“…Chronic CR disruption is correlated with a higher rate of cancer (Pukkala et al, 2002; Reynolds et al, 2002; Schernhammer et al, 2001), whereas stable CR entrainment is associated with increased quality of life and survival in cancer patients (Innominato et al, 2012; Mormont et al, 2000; Sephton et al, 2000). Repeated shifts in the light-dark cycle robustly increase LPS-induced mortality in mice (Castanon-Cervantes et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Circadian rhythms accelerate wound healing in female Siberian hamsters

Cable

Onishi

Prendergast

2017

Physiology & Behavior

View full text Add to dashboard Cite

Circadian rhythms (CRs) provide temporal regulation and coordination of numerous physiological traits, including immune function. CRs in multiple aspects of immune function are absent in rodents that have been rendered circadian-arrhythmic through various methods. In Siberian hamsters, circadian arrhythmia can be induced by disruptive light treatments (DPS). Here we examined CRs in wound healing, and the effects of circadian disruption on wound healing in DPS-arrhythmic hamsters. Circadian entrained/rhythmic (RHYTH) and behaviorally-arrhythmic (ARR) female hamsters were administered a cutaneous wound either 3 h after light onset (ZT03) or 2 h after dark onset (ZT18); wound size was quantified daily using image analyses. Among RHYTH hamsters, ZT03 wounds healed faster than ZT18 wounds, whereas in ARR hamsters, circadian phase did not affect wound healing. In addition, wounds healed slower in ARR hamsters. The results document a clear CR in wound healing, and indicate that the mere presence of organismal circadian organization enhances this aspect of immune function. Faster wound healing in CR-competent hamsters may be mediated by CR-driven coordination of the temporal order of mechanisms (inflammation, leukocyte trafficking, tissue remodeling) underlying cutaneous wound healing.

show abstract

Untitled

Cited by 99 publications

References 18 publications

The self-reported health of U.S. flight attendants compared to the general population

The self-reported health of U.S. flight attendants compared to the general population

Prevalence of risk factors for breast cancer in German airline cabin crew: a cross-sectional study

Circadian rhythms accelerate wound healing in female Siberian hamsters

Contact Info

Product

Resources

About