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Versluis, Astrid; Rump, Erik T.; Rensen, Patrick C.N.; Berkel, Theo J.C. Van; Bijsterbosch, Martin K.

doi:10.1023/a:1011917508056

Cited by 33 publications

(9 citation statements)

References 22 publications

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“…a lipophilic prodrug, of daunorubicin. into these liposomes (approximately ten prodrug molecules per particle: Versluis et al 1998). In the present study.…”

Section: Discussionmentioning

confidence: 62%

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Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes

Versluis¹,

Rensen²,

Rump³

et al. 1998

Br J Cancer

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Summary Many tumours express relatively high levels of low-density lipoprotein (LDL) receptors on their membranes. The LDL receptor is, therefore, an attractive target for the selective delivery of antineoplastic drugs to tumour cells. We reported previously on the synthesis of small apolipoprotein E (apoE)-containing liposomes that behave in vivo in a very similar way to native LDL. In this study, we (LAD). Tissue distribution studies showed that LAD-loaded apoE liposomes were taken up and processed by the major LDL receptor-expressing organs (i.e. adrenals, liver and spleen). Of all other tissues, the tumour showed the highest uptake. The distribution pattems of LAD-loaded apoE liposomes and native LDL in the tumour-bearing mice were very similar, which supports the role of the LDL receptor in the disposition of the prodrug-loaded particles. The disposition of LAD followed the pattem of the liposomal carrier. We conclude that apoE liposomes enable LDL receptor-mediated specific delivery of antineoplastic (pro)

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“…a lipophilic prodrug, of daunorubicin. into these liposomes (approximately ten prodrug molecules per particle: Versluis et al 1998). In the present study.…”

Section: Discussionmentioning

confidence: 62%

“…A lipophilic antineoplastic prodrug was synthesized. and incorporated in the liposomes (Versluis et al 1998). The prodrug.…”

mentioning

confidence: 99%

Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes

Versluis¹,

Rensen²,

Rump³

et al. 1998

Br J Cancer

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“…[68][69][70][71][72][73][74][75][76][77][78][79][80] Similarly, liposomes and polymeric nanoparticles have also been studied as a drug delivery system for various drugs. [81][82][83][84][85][86][87][88][89][90][91][92][93][94][95] Therefore, nanoparticles are now considered a good candidate not only to carry therapeutic agents but also capable of increasing its therapeutic effect.…”

Section: Nanotechnology and Drug Deliverymentioning

confidence: 99%

DNA Mediated Vaccines Delivery Through Nanoparticles

Shah¹,

Ali²,

Rostami³

et al. 2015

j nanosci nanotechnol

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Vaccination has led to the eradication of those diseases which had once claimed millions of lives worldwide; however, it is accompanied with a number of dis-advantages especially safety issues until the entry of DNA vaccines. The DNA vaccines have been emerged as the best remedy for problematic diseases being capable of producing humoral and cellular immune responses as well as the safest vaccines so far. However, the magnitude of immune responses produced in primates is lower than that in experimental animals. There are several reasons described theoretically for this limited efficacy and a number of novel approaches have been applied to boost their immune responses, e.g., use of more efficient promoters and coding optimization, addition of traditional or genetic adjuvants, electroporation, intradermal delivery and various prime-boost strategies. One of these strategies is controlled antigen administration of plasmid DNA through microspheres and nanoparticles. This approach is accompanied with a number of advantages to overcome the limitations of traditional delivery systems in terms of stability, solubility and pharmacology. Furthermore, the surface structure of a virus highly resembles with a nanoparticle because of their geometrical regularities and nanoscale dimensions; therefore, the engineering of nanoparticles is based upon principles of natural virus attack which will be the best tool for vaccination. There is evidence that these immune responses can be augmented by properly structured nanosized particles (nanoparticles) that may avoid DNA degradation and facilitate targeted delivery to antigen presenting cells. Adsorption, formulation or encapsulation with particles has been found to stabilize DNA formulations. The use of nanoparticles for DNA vaccine delivery is a platform technology and has been applied for delivery of a variety of existing and potential vaccines successfully.

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“…Besides having higher affinity to NPs to give a more stable corona, its amphipathic nature enables it to bind to hydrophobic lipid molecules, mediating the formation of soluble lipoproteins for their transport in the blood. , This could be extended to hydrophobic drug molecules to facilitate their dissolution in aqueous biological media for loading onto NPs without the need for prior chemical modifications. ApoE also contains an LDL-receptor binding domain , which could be exploited to target cancer cells that overexpress LDL receptors due to their high cholesterol requirements for forming cell membranes and proliferation …”

Section: Introductionmentioning

confidence: 99%

Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug Delivery

Yeo

Cheah

Thong

et al. 2019

ACS Appl. Nano Mater.

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The endogenously formed protein corona from human serum (HS) proteins on nanoparticles (NPs) has recently been exploited as a carrier for loading and delivery of small molecular therapeutics. However, not all serum corona proteins possess affinity for these therapeutics, which leads to reduced loading efficiency. Here, we enhance the utility of the protein corona by pre-forming a homogeneous protein corona around gold nanorods (NRs) using only apolipoprotein E (ApoE), which exhibits high affinity for both hydrophilic and hydrophobic drugs due to its amphipathic nature, as well as increased uptake by cancer cells overexpressing low-density lipoprotein (LDL) receptors. We loaded a hydrophobic photosensitizer chlorin e6 (Ce6) onto the ApoE corona around NRs, with the resulting NR-ApoE-Ce6 giving a much higher Ce6:NR ratio as compared to the HS corona. NR-ApoE-Ce6 also showed enhanced uptake of Ce6 in Cal 27 oral squamous cell carcinoma (OSCC) cells by up to 58.0% in vitro compared to same concentration of Ce6 alone formulated in ApoE. This resulted in a 27.0% increase in intracellular generation of reactive oxygen species (ROS) on irradiation with a 665 nm continuous wave laser. The combined photothermal therapy (PTT) by NRs and photodynamic therapy (PDT) by Ce6 achieved 96.7% destruction of cancer cells with just 3.33 pM NR-ApoE-Ce6 loaded with 2 μM Ce6, as compared to 78.4% of cell kill with an equivalent 2 μM free Ce6. The appropriate choice of specific proteins to form the protein corona around NPs could thus further improve the therapeutic loading capacity of the corona and consequently its therapeutic efficacy.

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Cited by 33 publications

References 22 publications

Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes

Low-density lipoprotein receptor-mediated delivery of a lipophilic daunorubicin derivative to B16 tumours in mice using apolipoprotein E-enriched liposomes

DNA Mediated Vaccines Delivery Through Nanoparticles

Gold Nanorods Coated with Apolipoprotein E Protein Corona for Drug Delivery

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