LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells

Jin, Chengni; Wei, Xue; Liu, Qi; Han, Jiahui; Luo, Ruilin; Feng, Jiayu; Liu, Jiayu; Guo, Tianmin; Peng, Xiaoli; Hu, Tianming

doi:10.1016/j.fct.2021.112350

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…As an example of these dynamics, we find STK11, a multifunctional gene [ 19 ] that acts as a tumor suppressor in non-small cell lung cancers [ 20 ], is highly mutated and its expression is reduced by about 50%. Mutations in STK11 in lung cancer are truncating and truncation with loss of function [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Gatenby,

Luddy,

Teer

et al. 2024

Med Oncol

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Somatic evolution selects cancer cell phenotypes that maximize survival and proliferation in dynamic environments. Although cancer cells are molecularly heterogeneous, we hypothesized convergent adaptive strategies to common host selection forces can be inferred from patterns of epigenetic and genetic evolutionary selection in similar tumors. We systematically investigated gene mutations and expression changes in lung adenocarcinomas with no common driver genes (n = 313). Although 13,461 genes were mutated in at least one sample, only 376 non-synonymous mutations evidenced positive evolutionary selection with conservation of 224 genes, while 1736 and 2430 genes exhibited ≥ two-fold increased and ≥ 50% decreased expression, respectively. Mutations under positive selection are more frequent in genes with significantly altered expression suggesting they often “hardwire” pre-existing epigenetically driven adaptations. Conserved genes averaged 16-fold higher expression in normal lung tissue compared to those with selected mutations demonstrating pathways necessary for both normal cell function and optimal cancer cell fitness. The convergent LUAD phenotype exhibits loss of differentiated functions and cell–cell interactions governing tissue organization. Conservation with increased expression is found in genes associated with cell cycle, DNA repair, p53 pathway, epigenetic modifiers, and glucose metabolism. No canonical driver gene pathways exhibit strong positive selection, but extensive down-regulation of membrane ion channels suggests decreased transmembrane potential may generate persistent proliferative signals. NCD LUADs perform niche construction generating a stiff, immunosuppressive microenvironment through selection of specific collagens and proteases. NCD LUADs evolve to a convergent phenotype through a network of interconnected genetic, epigenetic, and ecological pathways.

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Section: Resultsmentioning

confidence: 99%

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Gatenby,

Luddy,

Teer

et al. 2024

Med Oncol

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show abstract

“…LKB1 also can inhibit cell growth through suppressing the anti-apoptotic factors, such as STAT3, JNK, KRAS, MAPK, cyclooxygenase-2, and c-myc [42,59,60]. In recent studies, LKB1-AMPK is still the major signaling pathway to regulate cell apoptosis [61][62][63]. The role of LKB1 plays in epithelial polarity is associated with MARK/PAR1 and AMPK.…”

Section: Plos Onementioning

confidence: 99%

Hotspots and trends in liver kinase B1 research: A bibliometric analysis

Song

Zhao

et al. 2021

PLoS ONE

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Introduction In the past 22 years, a large number of publications have reported that liver kinase B1 (LKB1) can regulate a variety of cellular processes and play an important role in many diseases. However, there is no systematic bibliometric analysis on the publications of LKB1 to reveal the research hotspots and future direction. Methods Publications were retrieved from the Web of Science Core Collection (WoSCC), Scopus, and PubMed databases. CiteSpace and VOSviewer were used to analysis the top countries, institutions, authors, source journals, discipline categories, references, and keywords. Results In the past 22 years, the number of LKB1 publications has increased gradually by year. The country, institution, author, journals that have published the most articles and cited the most frequently were the United States, Harvard University, Prof. Benoit Viollet, Journal of Biochemistry and Plos One. The focused research hotspot was the molecular functions of LKB1. The emerging hotspots and future trends are the clinical studies about LKB1 and co-mutated genes as biomarkers in tumors, especially in lung adenocarcinoma. Conclusions Our research could provide knowledge base, frontiers, emerging hotspots and future trends associated with LKB1 for researchers in this field, and contribute to finding potential cooperation possibilities.

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“…25 Jin et al found that the LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulated 3-MCPD-induced cell apoptosis. 26 Biological rhythm is an internal rhythm of change evolved by organisms to adapt to the diurnal changes of the external environment. 27,28 The circadian rhythm of mitochondrial dynamics is regulated by circadian clock genes that mediate the expression of mitochondrial dynamic molecules and affect mitochondrial morphology and function.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Peng et al found that 3-MCPD induced apoptosis via mitochondrial oxidative phosphorylation system impairment and the caspase cascade pathway . Jin et al found that the LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulated 3-MCPD-induced cell apoptosis …”

Section: Introductionmentioning

confidence: 99%

3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2

Guan,

Wang,

Zhang

et al. 2023

J. Agric. Food Chem.

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LKB1/AMPKα signaling pathway and mitochondrial fission/fusion dynamics regulate apoptosis induced by 3-chlorpropane-1,2-diol in HEK293 cells

Cited by 6 publications

References 41 publications

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Lung adenocarcinomas without driver genes converge to common adaptive strategies through diverse genetic, epigenetic, and niche construction evolutionary pathways

Hotspots and trends in liver kinase B1 research: A bibliometric analysis

3-MCPD Induced Mitochondrial Damage of Renal Cells Via the Rhythmic Protein BMAL1 Targeting SIRT3/SOD2

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