Lizard Erythrocytic Virus in East African Chameleons

Telford, Sam R.; Jacobson, Elliott R.

doi:10.7589/0090-3558-29.1.57

Cited by 43 publications

(22 citation statements)

References 9 publications

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“…The absence of clinical symptoms and the restriction of the infection to erythrocytes in most experiments agree with results from other studies [4,8] that showed most of the erythrocytic ICDV infections to be benign. However, morbidity resulting from anemia may occur in fish [7,[19][20][21] and in heavy infections of captive reptiles [8,18].…”

Section: Transmission Of Infectionsupporting

confidence: 81%

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Experimental Infection of Lacertids with Lizard Erythrocytic Viruses

2002

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Objective: Lizard erythrocytic viruses (LEVs) produce inclusions in the cytoplasm of erythrocytes, but their impact on the infected host is poorly understood. This work reports on an experimental study of the infection process in Lacerta monticola and Lacerta schreiberi from Serra da Estrela Mountain, Portugal. Methods: A time sequence light microscope and transmission electron microscope (TEM) study of the infection process was performed in peripheral blood erythrocytes of experimentally infected lizards. Virions were searched for by TEM in visceral organs and bone marrow of the animals. Results: Infection was usually restricted to erythrocytes, but occasionally became systemic and induced disease. In the first case, a prevalence of infected erythrocytes of up to 98% followed by recovery was observed. In the latter, infection spread to leukocytes, leading to the death of the infected animals. Conclusions: The potential of LEVs to induce systemic infections was demonstrated. Sequential TEM examination of LEV-infected cells is described for the first time, demonstrating features such as dense inclusions related to virus nucleoid formation, intranuclear virions, intermediate structures in virion capsid morphogenesis and virus release by budding.

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Section: Transmission Of Infectionsupporting

confidence: 81%

“…These viruses have been called lizard erythrocytic viruses (LEVs) [4], snake erythrocytic viruses [5], frog erythrocytic viruses [6] and viral erythrocytic necrosis viruses [7], respectively.…”

Section: Introductionmentioning

confidence: 99%

Experimental Infection of Lacertids with Lizard Erythrocytic Viruses

2002

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“…27 Reptile EIVs have been reported in diverse squamate species. 18,36,37 Similarly in amphibians, Frog erythrocytic virus, which causes intraerythrocytic intracytoplasmic inclusions, is an iridovirus that does not belong to the genus Ranavirus. 5,10,32 Frog erythrocytic virus has been shown to measure 293-312 nm 32 ; this is larger than PvEIV, which measures 141-193 nm.…”

Section: Discussionmentioning

confidence: 99%

“…37 Within the family Agamidae, EIVs have been found in the Bibron's agama (Agama impalearis) 2 and the common agama (A. agama). 18,26 In some cases, erythrocytic inclusions have been associated with marked anemia, 17,26 but experimental infection has failed to reproduce anemia unless the lizards were maintained in a cold environment.…”

Section: Introductionmentioning

confidence: 99%

Intraerythrocytic iridovirus in central bearded dragons (Pogona vitticeps)

et al. 2014

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Abstract. Three adult central bearded dragons (Pogona vitticeps) originating from a commercial breeding facility presented with clinical signs, including anorexia, dehydration, white multifocal lesions on the dorsal aspect of the tongue, blepharospasm, and weight loss. In 1 of 3 lizards, a marked regenerative anemia was noted, and all 3 bearded dragons had erythrocytic intracytoplasmic inclusion bodies. Nine bearded dragons housed in contact also had identical, but fewer intraerythrocytic inclusions. Inclusion bodies examined by electron microscopy had particles consistent with iridoviruses. Attempts to culture the virus were unsuccessful; however, amplification and sequencing of regions of the viral DNA polymerase by polymerase chain reaction confirmed the presence of an iridovirus. One of the bearded dragons died, while the 2 others showing clinical signs were euthanized. The remaining 9 infected bearded dragons of the teaching colony were also euthanized. Postmortem examination revealed a moderate, multifocal, lymphoplasmacytic or mononuclear adenitis of the tongue in the 3 bearded dragons, and a lymphohistiocytic hepatitis with bacterial granulomas in 2 lizards.

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“…Viral replication takes place within the cytoplasm of host cells. These viruses have been identified in a variety of hosts including lizards (Telford and Jacobson 1993), frogs (Drury and others 1995), tortoises (Westhouse andothers 1996, Marschang andothers 1999), snakes (Johnsrude and others 1997), fish (Mao and others 1997) and turtles (Chen and others 1999). The aetiological role and pathogenicity of iridoviruses, however, has not always been established, and further study of this isolate, thought to be the first isolation of a suspected iridovirus from chameleons in the UK, iS recommended.…”

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confidence: 99%

Abstract

2002

Veterinary Record

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Lizard Erythrocytic Virus in East African Chameleons

Cited by 43 publications

References 9 publications

Experimental Infection of Lacertids with Lizard Erythrocytic Viruses

Experimental Infection of Lacertids with Lizard Erythrocytic Viruses

Intraerythrocytic iridovirus in central bearded dragons (Pogona vitticeps)

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